Replacement of Thr32 and Gln34 in the C-Terminal Neuropeptide Y Fragment 25–36 by cis-Cyclobutane and cis-Cyclopentane β-Amino Acids Shifts Selectivity toward the Y4 Receptor

2013 ◽  
Vol 56 (21) ◽  
pp. 8422-8431 ◽  
Author(s):  
Łukasz Berlicki ◽  
Melanie Kaske ◽  
Raquel Gutiérrez-Abad ◽  
Günther Bernhardt ◽  
Ona Illa ◽  
...  
Keyword(s):  
Amino Acids ◽  
Neuropeptide Y ◽  
Y Fragment ◽  
Y4 Receptor

Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice

2010 ◽  
Vol 627 (1-3) ◽  
pp. 258-264 ◽  
Author(s):  
Ryuichi Moriya ◽  
Toru Fujikawa ◽  
Junko Ito ◽  
Takashi Shirakura ◽  
Hiroyasu Hirose ◽  
...  
Keyword(s):  
Muscle Contraction ◽  
Neuropeptide Y ◽  
Pancreatic Polypeptide ◽  
Fecal Output ◽  
Y4 Receptor

scholarly journals Long-term depression-like effect of a single immune challenge in neuropeptide Y Y2 and Y4 receptor knockout mice

2008 ◽  
Vol 8 (S1) ◽  
Author(s):  
Evelin Painsipp ◽  
Herbert Herzog ◽  
Günther Sperk ◽  
Peter Holzer
Keyword(s):  
Neuropeptide Y ◽  
Knockout Mice ◽  
Immune Challenge ◽  
Long Term Depression ◽  
Y4 Receptor

scholarly journals Neuropeptide Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Annette Beck-Sickinger ◽  
William F. Colmers ◽  
Helen M. Cox ◽  
Henri N. Doods ◽  
Herbert Herzog ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Peptide Yy ◽  
Functional Gene ◽  
Peptide Sequence ◽  
Receptor Subtypes ◽  
Human Sequence ◽  
Npy Receptor ◽  
Y4 Receptor ◽  
Y Receptors ◽  
Neuropeptide Y Receptors

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [156]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified as the Y3 receptor has been identified as the CXCR4 chemokine recepter (originally named LESTR, [137]). The y6 receptor is a functional gene product in mouse, absent in rat, but contains a frame-shift mutation in primates producing a truncated non-functional gene [83]. Many of the agonists exhibit differing degrees of selectivity dependent on the species examined. For example, the potency of PP is greater at the rat Y4 receptor than at the human receptor [61]. In addition, many agonists lack selectivity for individual subtypes, but can exhibit comparable potency against pairs of NPY receptor subtypes, or have not been examined for activity at all subtypes. [125I]-PYY or [125I]-NPY can be used to label Y1, Y2, Y5 and y6 subtypes non-selectively, while [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP may be used to label Y5 receptors preferentially (note that cPP denotes chicken peptide sequence and hPP is the human sequence).

Oligopeptides as Neuropeptide Y Y4 Receptor Ligands: Identification of a High-Affinity Tetrapeptide Agonist and a Hexapeptide Antagonist

2020 ◽  
Vol 63 (15) ◽  
pp. 8198-8215
Author(s):  
Adam Konieczny ◽  
Diana Braun ◽  
David Wifling ◽  
Günther Bernhardt ◽  
Max Keller
Keyword(s):  
Neuropeptide Y ◽  
Receptor Ligands ◽  
High Affinity ◽  
Y4 Receptor

Cardiac function in neuropeptide Y Y4 receptor-knockout mice

2002 ◽  
Vol 110 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Margaret A Smith-White ◽  
Herbert Herzog ◽  
Erica K Potter
Keyword(s):  
Cardiac Function ◽  
Neuropeptide Y ◽  
Knockout Mice ◽  
Y4 Receptor

scholarly journals Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice

2008 ◽  
Vol 7 (5) ◽  
pp. 532-542 ◽  
Author(s):  
E. Painsipp ◽  
T. Wultsch ◽  
M. E. Edelsbrunner ◽  
R. O. Tasan ◽  
N. Singewald ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Knockout Mice ◽  
Y4 Receptor
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