Conformational Modifications of gB from Herpes Simplex Virus Type 1 Analyzed by Synthetic Peptides

2013 ◽  
Vol 56 (21) ◽  
pp. 8366-8376 ◽  
Author(s):  
Marco Cantisani ◽  
Annarita Falanga ◽  
Novella Incoronato ◽  
Luigi Russo ◽  
Alfonso De Simone ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Peptides ◽  
Simplex Virus

scholarly journals Infectivity inhibition by overlapping synthetic peptides derived from the gH/gL heterodimer of herpes simplex virus type 1

2017 ◽  
Vol 23 (4) ◽  
pp. 311-319 ◽  
Author(s):  
Gianluigi Franci ◽  
Annarita Falanga ◽  
Carla Zannella ◽  
Veronica Folliero ◽  
Francesca Martora ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Peptides ◽  
Simplex Virus

scholarly journals Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B

2006 ◽  
Vol 87 (5) ◽  
pp. 1085-1097 ◽  
Author(s):  
Stefania Galdiero ◽  
Mariateresa Vitiello ◽  
Marina D'Isanto ◽  
Annarita Falanga ◽  
Craig Collins ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Peptides ◽  
Coiled Coils ◽  
Heptad Repeat ◽  
Virus Infectivity ◽  
Simplex Virus

Human herpesviruses enter cells by fusion of their own membrane with a cellular membrane through the concerted action of multiple viral proteins and cellular receptors. Two conserved viral glycoproteins, gB and gH, are required for herpes simplex virus type 1 (HSV-1)-mediated membrane fusion, but little is known of how these proteins cooperate during entry. Both glycoproteins were shown to contain heptad repeat (HR) sequences predicted to form α-helical coiled coils, and the inhibitory activity against infection of four sets of synthetic peptides corresponding to HR1 and HR2 of gB and gH was tested. The interactions between these HR peptides were also investigated by circular dichroism, native polyacrylamide-gel electrophoresis and size exclusion high-performance liquid chromatography. gH coiled-coil peptides were more effective than gB coiled-coils peptides in inhibiting virus infectivity. The peptides did not impair fusion when added to cells immediately after infection. In contrast, inhibition of infection was observed, albeit to various extents, when peptides were added to virus before or during inoculation. The results of biophysical analyses were indicative of the existence of an interaction between HR1 and HR2 of gH and suggest that the HRs of gB and gH do not interact with each other.

T cell responses to synthetic peptides of herpes simplex virus type 1 glycoprotein D in naturally infected individuals

1993 ◽  
Vol 130 (1-2) ◽  
pp. 187-193 ◽  
Author(s):  
R. A. Damhof ◽  
J. W. Drijfhout ◽  
A. J. Scheffer ◽  
J. B. Wilterdink ◽  
G. W. Welling ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Peptides ◽  
Glycoprotein D ◽  
Cell Responses ◽  
Simplex Virus

Reactivity of human sera with overlapping synthetic peptides of herpes simplex virus type 1 glycoprotein D

1990 ◽  
Vol 114 (3-4) ◽  
pp. 251-258 ◽  
Author(s):  
H. J. Geerligs ◽  
M. Feijlbrief ◽  
M. Bolk ◽  
C. A. Bos ◽  
J. W. Drijfhout ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Peptides ◽  
Glycoprotein D ◽  
Human Sera ◽  
Simplex Virus

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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