Design, Synthesis, and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Derk J. Hogenkamp; Thomas A. Ford-Hutchinson; Wen-Yen Li; Edward R. Whittemore; Ryan F. Yoshimura; Minhtam B. Tran; Timothy B. C. Johnstone; Gavin D. Bascom; Hannah Rollins; Lena Lu; Kelvin W. Gee

doi:10.1021/jm400704g

Design, Synthesis, and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm400704g ◽

2013 ◽

Vol 56 (21) ◽

pp. 8352-8365 ◽

Cited By ~ 12

Author(s):

Derk J. Hogenkamp ◽

Thomas A. Ford-Hutchinson ◽

Wen-Yen Li ◽

Edward R. Whittemore ◽

Ryan F. Yoshimura ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Type I ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Design, Synthesis, and Functional Evaluation of a Novel Series of Phosphonate-Functionalized 1,2,3-Triazoles as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00348 ◽

2020 ◽

Vol 11 (17) ◽

pp. 2688-2704

Author(s):

Beatriz Elizabeth Nielsen ◽

Santiago Stabile ◽

Cristian Vitale ◽

Cecilia Bouzat

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Functional Evaluation ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Characterization of type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.06.067 ◽

2009 ◽

Vol 78 (7) ◽

pp. 914

Author(s):

Gareth T. Young ◽

Neil S. Millar

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Type I ◽

Allosteric Modulators ◽

Type Ii ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2012.07876.x ◽

2012 ◽

Vol 123 (1) ◽

pp. 73-83 ◽

Cited By ~ 25

Author(s):

Morten S. Thomsen ◽

Jens D. Mikkelsen

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Type I ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107

Molecular Pharmacology ◽

10.1124/mol.118.113340 ◽

2018 ◽

Vol 95 (1) ◽

pp. 43-61 ◽

Cited By ~ 9

Author(s):

Marta Quadri ◽

Sumanta Garai ◽

Ganesh A. Thakur ◽

Clare Stokes ◽

Alican Gulsevin ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.09.039 ◽

2014 ◽

Vol 86 ◽

pp. 724-739 ◽

Cited By ~ 14

Author(s):

Beatriz Balsera ◽

José Mulet ◽

Asia Fernández-Carvajal ◽

Roberto de la Torre-Martínez ◽

Antonio Ferrer-Montiel ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Privileged Structure ◽

Positive Allosteric Modulators

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Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2016.04.015 ◽

2016 ◽

Vol 76 ◽

pp. 19-30 ◽

Cited By ~ 9

Author(s):

Hugo R. Arias ◽

Federica Ravazzini ◽

Katarzyna M. Targowska-Duda ◽

Agnieszka A. Kaczor ◽

Dominik Feuerbach ◽

...

Keyword(s):

Ion Channels ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Voltage Gated ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Β Amyloid ◽

Positive Allosteric Modulators ◽

Voltage Gated Ion Channels

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Pharmacological Characterization of Natural Tobacco Alkaloids in the Presence of Positive Allosteric Modulators Against Human α4β2 and α7 Nicotinic Acetylcholine Receptors

Biophysical Journal ◽

10.1016/j.bpj.2019.11.790 ◽

2020 ◽

Vol 118 (3) ◽

pp. 119a

Author(s):

Omar Alijevic ◽

Damian Mc Hugh ◽

Anatoly Mazurov ◽

Julia Hoeng ◽

Manuel Peitsch

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Tobacco Alkaloids ◽

Positive Allosteric Modulators

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Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2021.06.006 ◽

2021 ◽

Vol 52 ◽

pp. 31-47

Author(s):

Katarzyna M. Targowska-Duda ◽

Barbara Budzynska ◽

Agnieszka Michalak ◽

Artur Wnorowski ◽

Claus J. Loland ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Type I ◽

Allosteric Modulators ◽

Type Ii ◽

Nicotinic Acetylcholine ◽

Reuptake Inhibition ◽

Pathway Activation ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Intracellular Pathway

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Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01492 ◽

2018 ◽

Vol 62 (1) ◽

pp. 159-173 ◽

Cited By ~ 3

Author(s):

Yuanheng Li ◽

Lilan Sun ◽

Taoyi Yang ◽

Wenxuan Jiao ◽

Jingshu Tang ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Design And Synthesis ◽

Auditory Gating ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01058 ◽

2021 ◽

Author(s):

Xintong Wang ◽

Haoran Xiao ◽

Jing Wang ◽

Zongze Huang ◽

Geng Peng ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Biological Evaluation ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Triazine Derivatives ◽

Positive Allosteric Modulators ◽

Synthesis And Biological Evaluation

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