A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

Yujun Zhao; Shanghai Yu; Wei Sun; Liu Liu; Jianfeng Lu; Donna McEachern; Sanjeev Shargary; Denzil Bernard; Xiaoqin Li; Ting Zhao; Peng Zou; Duxin Sun; Shaomeng Wang

doi:10.1021/jm4005708

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

Journal of Medicinal Chemistry ◽

10.1021/jm4005708 ◽

2013 ◽

Vol 56 (13) ◽

pp. 5553-5561 ◽

Cited By ~ 163

Author(s):

Yujun Zhao ◽

Shanghai Yu ◽

Wei Sun ◽

Liu Liu ◽

Jianfeng Lu ◽

...

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

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Faculty Opinions recommendation of Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717959626.793462957 ◽

2012 ◽

Author(s):

Mark Searcey

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Complete Tumor Regression ◽

Molecule Inhibitor ◽

Complete Tumor

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Structure-based discovery of a highly potent and orally active small-molecule inhibitor of embryonic ectoderm development (EED) capable of achieving complete tumor regression

10.1021/scimeetings.0c02817 ◽

2020 ◽

Author(s):

Rohan Kalyan Rej

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Complete Tumor Regression ◽

Molecule Inhibitor ◽

Embryonic Ectoderm Development ◽

Orally Active ◽

Embryonic Ectoderm ◽

Complete Tumor

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Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression

Journal of Medicinal Chemistry ◽

10.1021/jm3010306 ◽

2012 ◽

Vol 55 (19) ◽

pp. 8502-8514 ◽

Cited By ~ 32

Author(s):

Jianfang Chen ◽

Haibin Zhou ◽

Angelo Aguilar ◽

Liu Liu ◽

Longchuan Bai ◽

...

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Complete Tumor Regression ◽

Molecule Inhibitor ◽

Complete Tumor

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Structure-based discovery of a highly potent and orally active small-molecule inhibitor of embryonic ectoderm development (EED) capable of achieving complete tumor regression

10.1021/scimeetings.0c02819 ◽

2020 ◽

Author(s):

Rohan Kalyan Rej

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Complete Tumor Regression ◽

Molecule Inhibitor ◽

Embryonic Ectoderm Development ◽

Orally Active ◽

Embryonic Ectoderm ◽

Complete Tumor

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Faculty Opinions recommendation of Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021658.247635 ◽

2004 ◽

Author(s):

William Kaelin

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Shh Pathway ◽

Molecule Inhibitor

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Faculty Opinions recommendation of Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025625.322882 ◽

2005 ◽

Author(s):

James Stivers

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Atm Kinase ◽

Molecule Inhibitor ◽

Hiv 1

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Faculty Opinions recommendation of Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1033159.375732 ◽

2006 ◽

Author(s):

Berl R Oakley

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

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Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.520680 ◽

2007 ◽

Author(s):

Nathanael Gray

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

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Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.519039 ◽

2007 ◽

Author(s):

Tarun Kapoor

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

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Faculty Opinions recommendation of Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1283961.751061 ◽

2009 ◽

Author(s):

Marie-France Carlier

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Actin Assembly ◽

Molecule Inhibitor ◽

Identification And Characterization

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