Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

2013 ◽  
Vol 56 (8) ◽  
pp. 3379-3403 ◽  
Author(s):  
Kevin W. Hunt ◽  
Adam W. Cook ◽  
Ryan J. Watts ◽  
Christopher T. Clark ◽  
Guy Vigers ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein

Amyloid β-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation

1995 ◽  
Vol 199 (3) ◽  
pp. 203-206 ◽  
Author(s):  
Lars Lannfelt ◽  
Hans Basun ◽  
Carmen Vigo-Pelfrey ◽  
Lars-Olof Wahlund ◽  
Bengt Winblad ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Peptide ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation

Changes in Amyloid-  and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein

2013 ◽  
Vol 5 (194) ◽  
pp. 194re2-194re2 ◽  
Author(s):  
L. F. Maia ◽  
S. A. Kaeser ◽  
J. Reichwald ◽  
M. Hruscha ◽  
P. Martus ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein

A Numerical Study of Sensitivity Coefficients for a Model of Amyloid Precursor Protein and Tubulin-Associated Unit Protein Transport and Agglomeration in Neurons at the Onset of Alzheimer's Disease

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
I. A. Kuznetsov ◽  
A. V. Kuznetsov
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Tau Protein ◽  
Protein Transport ◽  
Numerical Study ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Model Parameters ◽  
In The Beginning

Modeling of intracellular processes occurring during the development of Alzheimer's disease (AD) can be instrumental in understanding the disease and can potentially contribute to finding treatments for the disease. The model of intracellular processes in AD, which we previously developed, contains a large number of parameters. To distinguish between more important and less important parameters, we performed a local sensitivity analysis of this model around the values of parameters that give the best fit with published experimental results. We show that the influence of model parameters on the total concentrations of amyloid precursor protein (APP) and tubulin-associated unit (tau) protein in the axon is reciprocal to the influence of the same parameters on the average velocities of the same proteins during their transport in the axon. The results of our analysis also suggest that in the beginning of AD the aggregation of amyloid-β and misfolded tau protein have little effect on transport of APP and tau in the axon, which suggests that early damage in AD may be reversible.

scholarly journals Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135741 ◽  
Author(s):  
Isabelle Bourdet ◽  
Aurélie Lampin-Saint-Amaux ◽  
Thomas Preat ◽  
Valérie Goguel
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Memory Deficit ◽  
Precursor Protein ◽  
Amyloid Β Peptide ◽  
Loss Of Function ◽  
Protein Loss

Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

2000 ◽  
Vol 278 (3) ◽  
pp. 169-172 ◽  
Author(s):  
Kristina Sennvik ◽  
Johan Fastbom ◽  
Mari Blomberg ◽  
Lars-Olof Wahlund ◽  
Bengt Winblad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Amyloid Precursor Protein ◽  
Precursor Protein
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