Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

2013 ◽  
Vol 56 (10) ◽  
pp. 3889-3903 ◽  
Author(s):  
Yi-Hui Peng ◽  
Hui-Yi Shiao ◽  
Chih-Hsiang Tu ◽  
Pang-Min Liu ◽  
John Tsu-An Hsu ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Protein Kinase Inhibitor ◽  
Inhibitor Design ◽  
Epidermal Growth

scholarly journals Role of epidermal growth factor receptor and microbial infections in polycystic kidney disease

2021 ◽  
Vol 8 (2) ◽  
pp. 65-73
Author(s):  
Kamila Orzechowska ◽  
SN Muhammad ◽  
H Mokamil
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Kidney Disease ◽  
Epidermal Growth Factor ◽  
Polycystic Kidney Disease ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Polycystic Kidney ◽  
Epidermal Growth

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a frequently inherited diseases associated with the presence of fluid-filled cysts. Epidermal Growth Factor Receptor (EGFR) plays role in cysts development Material and methods: The following tools (PubMed, PubMed Central, Medline Search Engine, Locate and Google Scholar) were used in literature search. Key words used to search for relevant literature are: Polycystic Kidney Disease, Epidermal Growth Factor Receptor, Tyrosine Kinase Inhibitor, Renal Cyst Formation and Renal Cyst Infection. The studies beyond 10 years were not included in present study. Analysis: The cross-examination of research papers allowed to analyse literature around role of EGFR in ADPKD pathophysiology, EGFR TKI as treatment of ADPKD and role of microbial cyst infections in disease progression. Results: There is a small body of literature that look at EGFR, Tyrosine Kinase Inhibitor (TKI) and cyst infection in ADPKD over the last decade. The ‘crosstalk’ between Src and EGFR was observed to have an impact on cyst development and progression. Therefore, the combined treatment with different compounds can be a desirable approach in the treatment of ADPKD. There has been observed relationship between cyst infections, decrease in kidney function and PKD gene mutation. Endotoxins of Gram-negative bacteria could be involved in disease development. Conclusion: The understanding of mechanisms of ADPKD and several cancers has led to the identification of molecular targets, and one of these is EGFR. The further study could establish the role of endotoxin in ADPKD development and its interaction with EGFR.

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