Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins

2013 ◽  
Vol 56 (7) ◽  
pp. 2813-2827 ◽  
Author(s):  
Raquel Álvarez ◽  
Pilar Puebla ◽  
J. Fernando Díaz ◽  
Ana C. Bento ◽  
Rósula García-Navas ◽  
...  
Keyword(s):  
Tubulin Inhibitors

scholarly journals Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Yang Ping Quan ◽  
Li Ping Cheng ◽  
Tian Chi Wang ◽  
Wan Pang ◽  
Fan Hong Wu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Hepg2 Cells ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Tubulin Inhibitors ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Compound 13a, more effective than CA-4 against HepG2 cells and tubulin, and the proposed binding mode for 13a.

scholarly journals Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Ibrahim Bin Sayeed ◽  
V. Lakshma Nayak ◽  
Mohd Adil Shareef ◽  
Neeraj Kumar Chouhan ◽  
Ahmed Kamal
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Human Cancer Cell Lines ◽  
Tubulin Inhibitors ◽  
Synthesis And Biological Evaluation

A library of imidazopyridine–propenone conjugates (8a–8u) were synthesized and evaluated for their antitumor activity against four human cancer cell lines.

Theoretical studies on QSAR and mechanism of 2-indolinone derivatives as tubulin inhibitors

2008 ◽  
Vol 109 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Si Yan Liao ◽  
Li Qian ◽  
Ti Fang Miao ◽  
Hai Liang Lu ◽  
Kang Cheng Zheng
Keyword(s):  
Theoretical Studies ◽  
Tubulin Inhibitors

Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors

2018 ◽  
Vol 92 (1) ◽  
pp. 1161-1170 ◽  
Author(s):  
Giuseppe Felice Mangiatordi ◽  
Daniela Trisciuzzi ◽  
Rosamaria Iacobazzi ◽  
Nunzio Denora ◽  
Leonardo Pisani ◽  
...  
Keyword(s):  
Automated Identification ◽  
Tubulin Inhibitors

Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors

2017 ◽  
Vol 136 ◽  
pp. 184-194 ◽  
Author(s):  
Mukund P. Tantak ◽  
Linus Klingler ◽  
V. Arun ◽  
Anil Kumar ◽  
Rachna Sadana ◽  
...  
Keyword(s):  
Tubulin Inhibitors ◽  
Design And Synthesis
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