Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

José-Ignacio Andrés; Jesús Alcázar; José María Cid; Meri De Angelis; Laura Iturrino; Xavier Langlois; Hilde Lavreysen; Andrés A. Trabanco; Sofie Celen; Guy Bormans

doi:10.1021/jm300912k

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Journal of Medicinal Chemistry ◽

10.1021/jm300912k ◽

2012 ◽

Vol 55 (20) ◽

pp. 8685-8699 ◽

Cited By ~ 33

Author(s):

José-Ignacio Andrés ◽

Jesús Alcázar ◽

José María Cid ◽

Meri De Angelis ◽

Laura Iturrino ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Allosteric Modulators ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Positive Allosteric Modulators

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In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-010-1723-7 ◽

2011 ◽

Vol 38 (6) ◽

pp. 1083-1094 ◽

Cited By ~ 39

Author(s):

Christine DeLorenzo ◽

Matthew S. Milak ◽

Kathleen G. Brennan ◽

J. S. Dileep Kumar ◽

J. John Mann ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00209 ◽

2016 ◽

Vol 59 (8) ◽

pp. 3980-3990 ◽

Cited By ~ 3

Author(s):

Yoko Shimoda ◽

Tomoteru Yamasaki ◽

Masayuki Fujinaga ◽

Masanao Ogawa ◽

Yusuke Kurihara ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.11.048 ◽

2011 ◽

Vol 19 (1) ◽

pp. 102-110 ◽

Cited By ~ 33

Author(s):

Masayuki Fujinaga ◽

Tomoteru Yamasaki ◽

Kazunori Kawamura ◽

Katsushi Kumata ◽

Akiko Hatori ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Type ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rodent Brain

Journal of Medicinal Chemistry ◽

10.1021/jm201590g ◽

2012 ◽

Vol 55 (5) ◽

pp. 2342-2352 ◽

Cited By ~ 27

Author(s):

Masayuki Fujinaga ◽

Tomoteru Yamasaki ◽

Joji Yui ◽

Akiko Hatori ◽

Lin Xie ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Rodent Brain ◽

Positron Emission

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Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.03.046 ◽

2011 ◽

Vol 21 (10) ◽

pp. 2998-3001 ◽

Cited By ~ 23

Author(s):

Tomoteru Yamasaki ◽

Masayuki Fujinaga ◽

Yuichiro Yoshida ◽

Katsushi Kumata ◽

Joji Yui ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

Preliminary Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Positron Emission Tomography Ligand

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Radiosynthesis and Evaluation of an18F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu4)

Journal of Medicinal Chemistry ◽

10.1021/jm501245b ◽

2014 ◽

Vol 57 (21) ◽

pp. 9130-9138 ◽

Cited By ~ 14

Author(s):

Kun-Eek Kil ◽

Pekka Poutiainen ◽

Zhaoda Zhang ◽

Aijun Zhu ◽

Ji-Kyung Choi ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

Metabotropic Glutamate ◽

Positron Emission

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Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2009.03.005 ◽

2009 ◽

Vol 36 (6) ◽

pp. 613-622 ◽

Cited By ~ 14

Author(s):

Christophe Lucatelli ◽

Michael Honer ◽

Jean-Frédéric Salazar ◽

Tobias L. Ross ◽

P. August Schubiger ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission

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Preclinical and the first clinical studies on [11C]ITMM for mapping metabotropic glutamate receptor subtype 1 by positron emission tomography

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2012.11.008 ◽

2013 ◽

Vol 40 (2) ◽

pp. 214-220 ◽

Cited By ~ 12

Author(s):

Jun Toyohara ◽

Muneyuki Sakata ◽

Masayuki Fujinaga ◽

Tomoteru Yamasaki ◽

Keiichi Oda ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Clinical Studies ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

Metabotropic Glutamate ◽

Positron Emission

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Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography

Neuropsychopharmacology ◽

10.1038/sj.npp.1300902 ◽

2005 ◽

Vol 31 (5) ◽

pp. 967-977 ◽

Cited By ~ 31

Author(s):

Bart N M van Berckel ◽

Lawrence S Kegeles ◽

Rikki Waterhouse ◽

Ningning Guo ◽

Dah-Ren Hwang ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Receptor Agonist ◽

Dopamine Release ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Group Ii ◽

Glutamate Receptor Agonist

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Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01394 ◽

2020 ◽

Vol 63 (20) ◽

pp. 12060-12072

Author(s):

Gengyang Yuan ◽

Xiying Qu ◽

Baohui Zheng ◽

Ramesh Neelamegam ◽

Sepideh Afshar ◽

...

Keyword(s):

Metabotropic Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Synthesis And Characterization ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

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