Synthesis and Biological Evaluation of New Amino Acid and Dipeptide Derivatives of Neocryptolepine as Anticancer Agents

2012 ◽  
Vol 55 (11) ◽  
pp. 5077-5087 ◽  
Author(s):  
Katarzyna Sidoryk ◽  
Marta Świtalska ◽  
Joanna Wietrzyk ◽  
Anna Jaromin ◽  
Magdalena Piętka-Ottlik ◽  
...  
Keyword(s):  
Amino Acid ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Synthesis and biological evaluation of chalcone derivatives of 1,2,4-thiadiazol-benzo[d]imidazol-2-yl)quinolin-2(1H)-one as anticancer agents

2020 ◽  
Vol 30 ◽  
pp. 100556
Author(s):  
Yazala Jyothsna Pragathi ◽  
Deekala Veronica ◽  
Kowthalam Anitha ◽  
Mandava Venkata Basaveswara Rao ◽  
Rudraraju Ramesh Raju
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Chalcone Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Synthesis and Biological Evaluation of Amide Derivatives of Imidazopyridine as Anticancer Agents

2019 ◽  
Vol 89 (7) ◽  
pp. 1491-1495 ◽  
Author(s):  
V. Ramesh ◽  
G. Purna Chander Rao ◽  
D. Ramachandran ◽  
A. Kalyan Chakravarthy
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Amide Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Molecular Modeling, Synthesis and Biological Evaluation of N-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5348
Author(s):  
Dima A. Sabbah ◽  
Shaima’ E. Hasan ◽  
Reema Abu Khalaf ◽  
Sanaa K. Bardaweel ◽  
Rima Hajjo ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Human Colon ◽  
Biological Evaluation ◽  
Phosphatidylinositol 3 Kinase ◽  
Gene Encoding ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Binding Residues ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives of N-phenyl-4-hydroxy-6-methyl-2-quinolone-3-carboxamide were synthesized and characterized using NMR (1H and 13C) and HRMS. The derivatives displayed inhibitory activity against human epithelial colorectal adenocarcinoma (Caco-2) and human colon cancer (HCT-116) cell lines: compounds 8 (IC50 Caco-2 = 98 µM, IC50 HCT-116 = 337 µM) and 16 (IC50 Caco-2 = 13 µM, IC50 HCT-116 = 240.2 µM). Results showed that compound 16 significantly affected the gene encoding AKT, BAD, and PI3K. The induced-fit docking (IFD) studies against PI3Kα demonstrated that the scaffold accommodates the kinase domains and forms H-bonds with significant binding residues.

Synthesis and biological evaluation of novel derivatives of gambogenic acid as anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 334-338 ◽  
Author(s):  
Peng Huang ◽  
Zhong Hu ◽  
Liqin He ◽  
Xiaoshan Wang ◽  
Yaxian Wu
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Tumor Cell Lines ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A series of novel derivatives of gambogenic acid (GNA) were synthesized and evaluated for their in vitro antiproliferative activity against four kinds of tumor cell lines. These compounds displayed potent antiproliferative activity. In particular, compound 3f exhibited superior antiproliferative activity against these tumor cell lines than GNA.

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