Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase

Solveigh C. Koeberle; Stefan Fischer; Dieter Schollmeyer; Verena Schattel; Christian Grütter; Daniel Rauh; Stefan A. Laufer

doi:10.1021/jm300327h

Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm300327h ◽

2012 ◽

Vol 55 (12) ◽

pp. 5868-5877 ◽

Cited By ~ 23

Author(s):

Solveigh C. Koeberle ◽

Stefan Fischer ◽

Dieter Schollmeyer ◽

Verena Schattel ◽

Christian Grütter ◽

...

Keyword(s):

Protein Kinase ◽

Biological Evaluation ◽

Mitogen Activated Protein Kinase ◽

Selective Inhibitors ◽

Design Synthesis ◽

Mitogen Activated Protein ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.09.016 ◽

2015 ◽

Vol 25 (22) ◽

pp. 5402-5408 ◽

Cited By ~ 7

Author(s):

Songnian Lin ◽

Sunita Malkani ◽

Matthew Lombardo ◽

Lihu Yang ◽

Sander G. Mills ◽

...

Keyword(s):

Protein Kinase ◽

Biological Evaluation ◽

Mitogen Activated Protein Kinase ◽

Design Synthesis ◽

Mitogen Activated Protein ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.06.036 ◽

2015 ◽

Vol 25 (17) ◽

pp. 3694-3698 ◽

Cited By ~ 11

Author(s):

Jinyuk Heo ◽

Hanbo Shin ◽

Jun Lee ◽

Taelim Kim ◽

Kyung-Soo Inn ◽

...

Keyword(s):

Protein Kinase ◽

Biological Evaluation ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Mapk Inhibitors ◽

Synthesis And Biological Evaluation

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Chiral Sulfoxides as Metabolites of 2-Thioimidazole-Based p38α Mitogen-Activated Protein Kinase Inhibitors: Enantioselective Synthesis and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/jm101623p ◽

2011 ◽

Vol 54 (9) ◽

pp. 3283-3297 ◽

Cited By ~ 16

Author(s):

Stefanie Bühler ◽

Marcia Goettert ◽

Dieter Schollmeyer ◽

Wolfgang Albrecht ◽

Stefan A. Laufer

Keyword(s):

Protein Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Protein Kinase Inhibitors ◽

Enantioselective Synthesis ◽

Mitogen Activated Protein Kinase ◽

Chiral Sulfoxides ◽

Mitogen Activated Protein ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.06.007 ◽

2008 ◽

Vol 18 (14) ◽

pp. 4006-4010 ◽

Cited By ~ 3

Author(s):

Dae-Kee Kim ◽

Jin-Hwi Lim ◽

Jung A. Lee ◽

Purushottam M. Dewang

Keyword(s):

Protein Kinase ◽

Biological Evaluation ◽

Mitogen Activated Protein Kinase ◽

Imidazole Derivatives ◽

Mitogen Activated Protein ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.10.073 ◽

2012 ◽

Vol 20 (1) ◽

pp. 356-367 ◽

Cited By ~ 8

Author(s):

Daisuke Minehira ◽

Daisuke Takeda ◽

Hirokazu Urata ◽

Atsushi Kato ◽

Isao Adachi ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Acetic Acids

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Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm101423y ◽

2011 ◽

Vol 54 (7) ◽

pp. 2255-2265 ◽

Cited By ~ 29

Author(s):

David M. Goldstein ◽

Michael Soth ◽

Tobias Gabriel ◽

Nolan Dewdney ◽

Andreas Kuglstatter ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Selective Inhibitors ◽

Mitogen Activated Protein ◽

Orally Bioavailable

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Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.09.012 ◽

2017 ◽

Vol 140 ◽

pp. 448-464 ◽

Cited By ~ 8

Author(s):

Shengbin Zhou ◽

Yanan Duan ◽

Jiang Wang ◽

Jin Zhang ◽

Haifeng Sun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Protein Kinase ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.03.005 ◽

2019 ◽

Vol 170 ◽

pp. 112-125 ◽

Cited By ~ 3

Author(s):

Xiaodong Ma ◽

Jun Wei ◽

Chang Wang ◽

Dongyan Gu ◽

Yongzhou Hu ◽

...

Keyword(s):

B Cell ◽

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103137 ◽

2019 ◽

Vol 91 ◽

pp. 103137 ◽

Cited By ~ 5

Author(s):

Pervaiz Ali Channar ◽

Hina Irum ◽

Abid Mahmood ◽

Ghulam Shabir ◽

Sumera Zaib ◽

...

Keyword(s):

Alkaline Phosphatase ◽

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV

Chemical Biology & Drug Design ◽

10.1111/cbdd.12898 ◽

2016 ◽

Vol 89 (5) ◽

pp. 741-754 ◽

Cited By ~ 22

Author(s):

Ehtesham Jameel ◽

Huma Naz ◽

Parvez Khan ◽

Mohd. Tarique ◽

Jitendra Kumar ◽

...

Keyword(s):

Protein Kinase ◽

Biological Evaluation ◽

Pyrimidine Derivatives ◽

Dependent Protein Kinase ◽

Design Synthesis ◽

Calcium Calmodulin Dependent ◽

Dependent Protein ◽

Potential Inhibitors ◽

Synthesis And Biological Evaluation

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