Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

2012 ◽  
Vol 55 (10) ◽  
pp. 4806-4823 ◽  
Author(s):  
Riccardo Zanaletti ◽  
Laura Bettinetti ◽  
Cristiana Castaldo ◽  
Giuseppe Cocconcelli ◽  
Thomas Comery ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Pentanoic Acid ◽  
Nicotinic Acetylcholine ◽  
Alpha 7

Synthesis and Pharmacological Characterization of Novel Analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165

2002 ◽  
Vol 45 (15) ◽  
pp. 3235-3245 ◽  
Author(s):  
Christopher G. V. Sharples ◽  
Gunter Karig ◽  
Graham L. Simpson ◽  
James A. Spencer ◽  
Emma Wright ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Pharmacological Characterization ◽  
Nicotinic Acetylcholine

SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

2009 ◽  
Vol 17 (14) ◽  
pp. 5247-5258 ◽  
Author(s):  
Simon N. Haydar ◽  
Chiara Ghiron ◽  
Laura Bettinetti ◽  
Hendrick Bothmann ◽  
Thomas A. Comery ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Biological Evaluation ◽  
Nicotinic Acetylcholine ◽  
Alpha 7
Sign in / Sign up

Export Citation Format

Share Document