Discovery of cis-N-(1-(4-(Methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: A 1,6-Disubstituted Indoline Derivative as a Highly Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) without Any Cardiovascular Liabilities

2012 ◽  
Vol 55 (2) ◽  
pp. 943-955 ◽  
Author(s):  
Subhash C. Annedi ◽  
Jailall Ramnauth ◽  
Shawn P. Maddaford ◽  
Paul Renton ◽  
Suman Rakhit ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Selective Inhibitor ◽  
Oxide Synthase

scholarly journals The Selective Inhibitor of Neuronal Nitric Oxide Synthase, 7-Nitroindazole, Reduces the Delayed Neuronal Damage Due to Forebrain Ischemia in Rats

Stroke ◽  
1998 ◽  
Vol 29 (6) ◽  
pp. 1248-1254 ◽  
Author(s):  
Kazunori Nanri ◽  
Céline Montécot ◽  
Véronique Springhetti ◽  
Jacques Seylaz ◽  
Elisabeth Pinard
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Damage ◽  
Neuronal Nitric Oxide Synthase ◽  
Selective Inhibitor ◽  
Forebrain Ischemia ◽  
Oxide Synthase

7-Nitroindazole, a selective inhibitor of neuronal nitric oxide synthase: effect on sevoflurane MAC and cerebellar cyclic GMP in mice

1998 ◽  
Vol 12 (3) ◽  
Author(s):  
Wei-dong Mi ◽  
Fumito Ichinose ◽  
Takahisa Goto ◽  
Yoshinari Niimi ◽  
Masanori Uchiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclic Gmp ◽  
Neuronal Nitric Oxide Synthase ◽  
Selective Inhibitor ◽  
Oxide Synthase

7-Nitroindazole, a selective inhibitor of neuronal nitric oxide synthase: effect on sevoflurane MAC and cerebellar cyclic GMP in mice

1998 ◽  
Vol 12 (3) ◽  
pp. 137-141
Author(s):  
Wei-Dong Mi ◽  
Fumito Ichinose ◽  
Takahisa Goto ◽  
Yoshinari Niimi ◽  
Masanori Uchiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclic Gmp ◽  
Neuronal Nitric Oxide Synthase ◽  
Selective Inhibitor ◽  
Oxide Synthase

scholarly journals Role of Zinc in Isoform-Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase,

Biochemistry ◽  
2010 ◽  
Vol 49 (51) ◽  
pp. 10803-10810 ◽  
Author(s):  
Silvia L. Delker ◽  
Fengtian Xue ◽  
Huiying Li ◽  
Joumana Jamal ◽  
Richard B. Silverman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Selective Inhibitor ◽  
Inhibitor Binding ◽  
Oxide Synthase
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