Structure–Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

2012 ◽  
Vol 55 (4) ◽  
pp. 1553-1558 ◽  
Author(s):  
Yoshitomo Suhara ◽  
Norika Hanada ◽  
Takashi Okitsu ◽  
Miho Sakai ◽  
Masato Watanabe ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Side Chain ◽  
Structure Activity ◽  
Relationship Of

Structure–activity relationship of new NLO organic materials based on push–pull azodyes: 4. Side chain polymers

Polymer ◽  
2000 ◽  
Vol 41 (2) ◽  
pp. 415-421 ◽  
Author(s):  
N Tirelli ◽  
A Altomare ◽  
R Solaro ◽  
F Ciardelli ◽  
S Follonier ◽  
...  
Keyword(s):  
Organic Materials ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Side Chain ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Structure-activity Relationship of Pamamycins: Effect of Side Chain Length on Aerial Mycelium-inducing Activity

2008 ◽  
Vol 61 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Ikuko Kozone ◽  
Makoto Hashimoto ◽  
Udo Gräfe ◽  
Hiroshi Kawaide ◽  
Hiroshi Abe ◽  
...  
Keyword(s):  
Chain Length ◽  
Aerial Mycelium ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Side Chain ◽  
Side Chain Length ◽  
Structure Activity ◽  
Relationship Of

Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4

Life Sciences ◽  
1997 ◽  
Vol 60 (15) ◽  
pp. 1263-1269 ◽  
Author(s):  
Aleksandra Misicka ◽  
Andrzej W. Lipkowski ◽  
Robert Horvath ◽  
Peg Davis ◽  
Frank Porreca ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure-Activity Relationship Study of Host-Specific Phytotoxins (AM-Toxin Analogs) Using a New Assay Method with Leaves from Apple Meristem Culture

2001 ◽  
Vol 56 (11-12) ◽  
pp. 1029-1037 ◽  
Author(s):  
Masahiro Miyashita ◽  
Tomoko Nakamori ◽  
Takahiro Murai ◽  
Tetsuro Yonemoto ◽  
Hisashi Miyagawa ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Ring Structure ◽  
Activity Relationship ◽  
Assay Method ◽  
Side Chain ◽  
Meristem Culture ◽  
Putative Receptor ◽  
Structure Activity ◽  
Stereoelectronic Properties ◽  
Relationship Of

Abstract AM -toxins are host-specific phytotoxins of the Alternaria alternata apple pathotype, which induce necrosis on apple leaves. In this study, we developed a new assay to measure the necrotic activity of AM -toxin analogs using cultured leaves from meristem cells. This method was not only more sensitive to AM -toxin I, but also more reliable than the previous one that used tree leaves due to the homogeneous nature of cultured leaves and to the method of application of toxins. U sing this assay method we investigated a structure-activity relationship of AM -toxin analogs synthesized in this study. Most residues and the macrocyclic ring structure were strictly recognized by AM -toxin putative receptor, whereas the L-Ala binding subsite of the receptor allowed for side chain structures with various stereoelectronic properties. These findings are important for designing ligands for further experimental probing of the nature of the receptor.

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