Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands

Xiyan Hou; Mahesh S. Majik; Kyunglim Kim; Yuna Pyee; Yoonji Lee; Varughese Alexander; Hwa-Jin Chung; Hyuk Woo Lee; Girish Chandra; Jin Hee Lee; Seul-gi Park; Won Jun Choi; Hea Ok Kim; Khai Phan; Zhan-Guo Gao; Kenneth A. Jacobson; Sun Choi; Sang Kook Lee; Lak Shin Jeong

doi:10.1021/jm201229j

Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands

Journal of Medicinal Chemistry ◽

10.1021/jm201229j ◽

2011 ◽

Vol 55 (1) ◽

pp. 342-356 ◽

Cited By ~ 26

Author(s):

Xiyan Hou ◽

Mahesh S. Majik ◽

Kyunglim Kim ◽

Yuna Pyee ◽

Yoonji Lee ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

Structure Activity Relationships ◽

Structure Activity ◽

A3 Adenosine Receptor ◽

Adenosine Derivatives ◽

Adenosine Receptor Ligands

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ChemInform Abstract: 1-Substituted 4-[Chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: Synthesis and Structure-Activity Relationships of a New Class of Benzodiazepine and Adenosine Receptor Ligands.

ChemInform ◽

10.1002/chin.199840166 ◽

2010 ◽

Vol 29 (40) ◽

pp. no-no

Author(s):

B. MATUSZCZAK ◽

E. PEKALA ◽

C. E. MUELLER

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

Structure Activity Relationships ◽

New Class ◽

Structure Activity ◽

Adenosine Receptor Ligands

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Structure–activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.03.034 ◽

2009 ◽

Vol 17 (10) ◽

pp. 3733-3738 ◽

Cited By ~ 13

Author(s):

Shantanu Pal ◽

Won Jun Choi ◽

Seung Ah Choe ◽

Cara L. Heller ◽

Zhan-Guo Gao ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

A3 Adenosine Receptor ◽

Adenosine Derivatives

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Synthesis and structure–activity relationships of 2-hydrazinyladenosine derivatives as A2A adenosine receptor ligands

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.11.021 ◽

2013 ◽

Vol 21 (2) ◽

pp. 436-447 ◽

Cited By ~ 3

Author(s):

Ali El-Tayeb ◽

Sabrina Gollos

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

A2a Adenosine Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Adenosine Receptor Ligands

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1-Substituted 4-[Chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: Synthesis and Structure-Activity Relationships of a New Class of Benzodiazepine and Adenosine Receptor Ligands

Archiv der Pharmazie ◽

10.1002/(sici)1521-4184(199805)331:5<163::aid-ardp163>3.0.co;2-3 ◽

1998 ◽

Vol 331 (5) ◽

pp. 163-169 ◽

Cited By ~ 10

Author(s):

Barbara Matuszczak ◽

Elšbieta Pekala ◽

Christa E. Müller

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

Structure Activity Relationships ◽

New Class ◽

Structure Activity ◽

Adenosine Receptor Ligands

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Quantitative Structure Activity Relationships as Useful Tools for the Design of New Adenosine Receptor Ligands. 1. Agonist

Current Medicinal Chemistry ◽

10.2174/092986706777935195 ◽

2006 ◽

Vol 13 (19) ◽

pp. 2253-2266 ◽

Cited By ~ 6

Author(s):

Aliuska Morales Helguera ◽

Marta Teijeira ◽

Carmen Teran ◽

Maykel Perez Gonzalez

Keyword(s):

Adenosine Receptor ◽

Quantitative Structure ◽

Receptor Ligands ◽

Structure Activity Relationships ◽

Structure Activity ◽

Adenosine Receptor Ligands ◽

Quantitative Structure Activity Relationships

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Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113607 ◽

2021 ◽

pp. 113607

Author(s):

Katarzyna Bednarska-Szczepaniak ◽

Adam Mieczkowski ◽

Aleksandra Kierozalska ◽

Dijana Saftić ◽

Konrad Głąbała ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

Boron Clusters ◽

A3 Adenosine Receptor ◽

Adenosine Derivatives ◽

Adenosine Receptor Ligands

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Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands

Current Topics in Medicinal Chemistry ◽

10.2174/1568026611313090007 ◽

2013 ◽

Vol 13 (9) ◽

pp. 1048-1068 ◽

Cited By ~ 4

Author(s):

Changliang Deng ◽

Feng Luan ◽

Maykel Cruz- Monteagudo ◽

Fernanda Borges ◽

M. Natalia D. S. Cordeiro

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

Recent Advances ◽

A3 Adenosine Receptor ◽

Agonist And Antagonist ◽

Adenosine Receptor Ligands

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Translocation of arrestin induced by human A3 adenosine receptor ligands in an engineered cell line: Comparison with G protein-dependent pathways

Pharmacological Research ◽

10.1016/j.phrs.2008.02.008 ◽

2008 ◽

Vol 57 (4) ◽

pp. 303-311 ◽

Cited By ~ 26

Author(s):

Z GAO ◽

K JACOBSON

Keyword(s):

Cell Line ◽

G Protein ◽

Adenosine Receptor ◽

Receptor Ligands ◽

A3 Adenosine Receptor ◽

Adenosine Receptor Ligands

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Synthesis and Structure-Activity Relationships of 4-Cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one Derivatives as A1 and A3 Adenosine Receptor Antagonists

Archiv der Pharmazie ◽

10.1002/ardp.200300816 ◽

2004 ◽

Vol 337 (1) ◽

pp. 35-41 ◽

Cited By ~ 6

Author(s):

Vittoria Colotta ◽

Daniela Catarzi ◽

Flavia Varano ◽

Guido Filacchioni ◽

Claudia Martini ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

A3 Adenosine Receptor

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A3 Adenosine Receptor Ligands: History and Perspectives

Medicinal Research Reviews ◽

10.1002/(sici)1098-1128(200003)20:2<103::aid-med1>3.0.co;2-x ◽

2000 ◽

Vol 20 (2) ◽

pp. 103-128 ◽

Cited By ~ 90

Author(s):

Pier Giovanni Baraldi ◽

Barbara Cacciari ◽

Romeo Romagnoli ◽

Stefania Merighi ◽

Katia Varani ◽

...

Keyword(s):

Adenosine Receptor ◽

Receptor Ligands ◽

A3 Adenosine Receptor ◽

Adenosine Receptor Ligands

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