Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Irene Bolea; Jordi Juárez-Jiménez; Cristóbal de los Rı́os; Mourad Chioua; Ramón Pouplana; F. Javier Luque; Mercedes Unzeta; José Marco-Contelles; Abdelouahid Samadi

doi:10.1021/jm200853t

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Journal of Medicinal Chemistry ◽

10.1021/jm200853t ◽

2011 ◽

Vol 54 (24) ◽

pp. 8251-8270 ◽

Cited By ~ 144

Author(s):

Irene Bolea ◽

Jordi Juárez-Jiménez ◽

Cristóbal de los Rı́os ◽

Mourad Chioua ◽

Ramón Pouplana ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase Inhibitors

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Design, synthesis and biological evaluation of 3,4-dihydro-2(1 H )-quinoline- O -alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.03.070 ◽

2017 ◽

Vol 25 (12) ◽

pp. 3006-3017 ◽

Cited By ~ 17

Author(s):

Zhipei Sang ◽

Wanli Pan ◽

Keren Wang ◽

Qinge Ma ◽

Lintao Yu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.12.028 ◽

2014 ◽

Vol 75 ◽

pp. 82-95 ◽

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Author(s):

Oscar M. Bautista-Aguilera ◽

Gerard Esteban ◽

Irene Bolea ◽

Katarina Nikolic ◽

Danica Agbaba ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitors ◽

Potential Treatment ◽

Design Synthesis ◽

Qsar Analysis ◽

Pharmacological Evaluation

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Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.07.031 ◽

2019 ◽

Vol 180 ◽

pp. 367-382 ◽

Cited By ~ 10

Author(s):

Changjun Zhang ◽

Ke Yang ◽

Sihang Yu ◽

Jing Su ◽

Shengli Yuan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Iron Chelates ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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New semicarbazones as gorge-spanning ligands of acetylcholinesterase and potential new drugs against Alzheimer’s disease: Synthesis, molecular modeling, NMR, and biological evaluation

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2017.1407676 ◽

2017 ◽

Vol 36 (15) ◽

pp. 4099-4113 ◽

Cited By ~ 13

Author(s):

Denise Cristian Ferreira Neto ◽

Josélia Alencar Lima ◽

Joyce Sobreiro Francisco Diz de Almeida ◽

Tanos Celmar Costa França ◽

Claudia Jorge do Nascimento ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Biological Evaluation ◽

New Drugs

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Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

Journal of Neural Transmission ◽

10.1007/s00702-012-0948-y ◽

2012 ◽

Vol 120 (6) ◽

pp. 893-902 ◽

Cited By ~ 86

Author(s):

Irene Bolea ◽

Alejandro Gella ◽

Mercedes Unzeta

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitors

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Monoamine oxidase inhibitors as treatment for depressed patients with primary degenerative dementia (Alzheimer's disease)

American Journal of Psychiatry ◽

10.1176/ajp.142.6.763 ◽

1985 ◽

Vol 142 (6) ◽

pp. 763-764 ◽

Cited By ~ 42

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitors ◽

Depressed Patients ◽

Degenerative Dementia ◽

Primary Degenerative Dementia

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7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

Molecules ◽

10.3390/molecules18022397 ◽

2013 ◽

Vol 18 (2) ◽

pp. 2397-2418 ◽

Cited By ~ 47

Author(s):

Katarina Spilovska ◽

Jan Korabecny ◽

Jan Kral ◽

Anna Horova ◽

Kamil Musilek ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Cholinesterase Inhibitors ◽

Biological Evaluation ◽

Disease Treatment ◽

Modeling Studies ◽

Molecular Modeling Studies

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Biological Evaluation of Halogenated Thioureas as Cholinesterases Inhibitors Against Alzheimer’s Disease & Molecular Modeling Studies

Letters in Drug Design & Discovery ◽

10.2174/1570180812666141201222247 ◽

2015 ◽

Vol 12 (6) ◽

pp. 488-494 ◽

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Author(s):

Jamshed Iqbal ◽

Sumera Zaib ◽

Aamer Saeed ◽

Muhammad Muddassar

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Molecular Modeling Studies

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Synthesis, biological evaluation and molecular modeling study of novel tacrine–carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.01.020 ◽

2014 ◽

Vol 75 ◽

pp. 21-30 ◽

Cited By ~ 75

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Supatra Thiratmatrakul ◽

Chavi Yenjai ◽

Pornthip Waiwut ◽

Opa Vajragupta ◽

Prasert Reubroycharoen ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Molecular Modeling ◽

Biological Evaluation ◽

Molecular Modeling Study ◽

Multifunctional Agents ◽

Modeling Study

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Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.09.055 ◽

2017 ◽

Vol 27 (22) ◽

pp. 5053-5059 ◽

Cited By ~ 13

Author(s):

Zhipei Sang ◽

Keren Wang ◽

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Lintao Yu ◽

Huijuan Wang ◽

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Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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