Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

Charles H. Mitch; Steven J. Quimby; Nuria Diaz; Concepcion Pedregal; Marta G. de la Torre; Alma Jimenez; Qing Shi; Emily J. Canada; Steven D. Kahl; Michael A. Statnick; David L. McKinzie; Dana R. Benesh; Karen S. Rash; Vanessa N. Barth

doi:10.1021/jm200789r

Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

Journal of Medicinal Chemistry ◽

10.1021/jm200789r ◽

2011 ◽

Vol 54 (23) ◽

pp. 8000-8012 ◽

Cited By ~ 58

Author(s):

Charles H. Mitch ◽

Steven J. Quimby ◽

Nuria Diaz ◽

Concepcion Pedregal ◽

Marta G. de la Torre ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Occupancy ◽

Preclinical Development ◽

Opioid Receptor Antagonist ◽

Selective Antagonists

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Faculty Opinions recommendation of A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119600.577817 ◽

2008 ◽

Author(s):

George Breese ◽

Mary Katherine Kelm

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Heavy Drinking ◽

Ethanol Consumption ◽

Delta Opioid Receptor ◽

Opioid Receptor Antagonist

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Faculty Opinions recommendation of Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718110987.793483835 ◽

2013 ◽

Author(s):

Pamela Mellon ◽

Alexander Kauffman

Keyword(s):

Luteinizing Hormone ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Hormone Secretion ◽

Kappa Opioid Receptor ◽

Female Rats ◽

Luteinizing Hormone Secretion ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Puberty Onset

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Faculty Opinions recommendation of The selective mu-opioid receptor antagonist ADL5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in MPTP-lesioned macaque model of Parkinson's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9987957.10722055 ◽

2011 ◽

Author(s):

Alfredo Berardelli ◽

Antonio Suppa

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Macaque Model ◽

Opioid Receptor Antagonist

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Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5'-guanidinonaltrindole and the biased kappa opioid receptor agonist 6'-guanidinonaltrindole in mice

Medicine in Drug Discovery ◽

10.1016/j.medidd.2021.100097 ◽

2021 ◽

pp. 100097

Author(s):

Alan Cowan ◽

Lee-Yuan Liu-Chen ◽

Saadet Inan

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Common Effect ◽

Opioid Receptor Agonist

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Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats

Pharmacology Biochemistry and Behavior ◽

10.1016/j.pbb.2021.173157 ◽

2021 ◽

pp. 173157

Author(s):

Jacobi I. Cunningham ◽

Mark S. Todtenkopf ◽

Reginald L. Dean ◽

Marc R. Azar ◽

George F. Koob ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Wistar Rats ◽

Self Administration ◽

Drug Induced ◽

Opioid Receptor Antagonist ◽

Extracellular Dopamine ◽

Male Wistar Rats

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Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice

Toxicology Letters ◽

10.1016/j.toxlet.2012.04.022 ◽

2012 ◽

Vol 212 (1) ◽

pp. 61-65 ◽

Cited By ~ 5

Author(s):

Chih-Cheng Chien ◽

Yih-Jing Lee ◽

Lir-Wan Fan ◽

Ing-Kang Ho ◽

Lu-Tai Tien

Keyword(s):

Locomotor Activity ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Opioid Receptor Antagonist

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1870 ALVIMOPAN, A PERIPHERALLY ACTING MU-OPIOID RECEPTOR ANTAGONIST, ACCELERATES GASTROINTESTINAL RECOVERY AND DECREASES LENGTH OF HOSPITAL STAY AFTER RADICAL CYSTECTOMY

The Journal of Urology ◽

10.1016/j.juro.2013.02.2289 ◽

2013 ◽

Vol 189 (4S) ◽

Cited By ~ 4

Author(s):

Ashish M Kamat ◽

Sam S Chang ◽

Cheryl Lee ◽

Gilad Amiel ◽

Timothy Beard ◽

...

Keyword(s):

Hospital Stay ◽

Receptor Antagonist ◽

Radical Cystectomy ◽

Opioid Receptor ◽

Length Of Hospital Stay ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Opioid Receptor Antagonist

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Naltrindole-5'-isothiocyanate: a nonequilibrium, highly selective .delta.-opioid receptor antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm00168a004 ◽

1990 ◽

Vol 33 (6) ◽

pp. 1547-1548 ◽

Cited By ~ 56

Author(s):

P. S. Portoghese ◽

M. Sultana ◽

A. E. Takemori

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Delta Opioid Receptor ◽

Opioid Receptor Antagonist

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Effects of Naldemedine, a Peripherally Acting μ-Opioid Receptor Antagonist, on Inhibition of Large Intestinal Transit Induced by Morphine in Rodent Models

Gastroenterology ◽

10.1016/s0016-5085(17)31879-6 ◽

2017 ◽

Vol 152 (5) ◽

pp. S508

Author(s):

Toshiyuki Kanemasa ◽

Hiroko Ono ◽

Atsushi Nakamura ◽

Yasuhidse Morioka ◽

Minoru Hasegawa

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Intestinal Transit ◽

Rodent Models ◽

Opioid Receptor Antagonist ◽

Μ Opioid Receptor

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Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery

Surgical Endoscopy ◽

10.1007/s00464-005-0104-y ◽

2005 ◽

Vol 20 (1) ◽

pp. 64-70 ◽

Cited By ~ 133

Author(s):

E. R. Viscusi ◽

S. Goldstein ◽

T. Witkowski ◽

A. Andonakakis ◽

R. Jan ◽

...

Keyword(s):

Abdominal Surgery ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Postoperative Ileus ◽

Mu Opioid Receptor ◽

Major Abdominal Surgery ◽

Mu Opioid ◽

Opioid Receptor Antagonist

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