Synthesis of Three Novel Fluorine-18 Labeled Analogues ofl-Deprenyl for Positron Emission Tomography (PET) studies of Monoamine Oxidase B (MAO-B)

2011 ◽  
Vol 54 (20) ◽  
pp. 7023-7029 ◽  
Author(s):  
Sangram Nag ◽  
Lutz Lehmann ◽  
Tobias Heinrich ◽  
Andrea Thiele ◽  
Georg Kettschau ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Emission Tomography ◽  
Monoamine Oxidase B ◽  
Mao B ◽  
Positron Emission

scholarly journals Kinetic Modeling of the Monoamine Oxidase B Radioligand [11C]SL25.1188 in Human Brain with High-Resolution Positron Emission Tomography

2014 ◽  
Vol 34 (5) ◽  
pp. 883-889 ◽  
Author(s):  
Pablo M Rusjan ◽  
Alan A Wilson ◽  
Laura Miler ◽  
Ian Fan ◽  
Romina Mizrahi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Monoamine Oxidase ◽  
Human Brain ◽  
Kinetic Modeling ◽  
Parent Compound ◽  
Emission Tomography ◽  
Monoamine Oxidase B ◽  
Mao B ◽  
Positron Emission

This article describes the kinetic modeling of [11C]SL25.1188 ([(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[ d]isoxazol-3-yl]-oxazolidin-2-[11C]one]) binding to monoamine oxidase B (MAO-B) in the human brain using high-resolution positron emission tomography (PET). Seven healthy subjects underwent two separate 90-minute PET scans after an intravenous injection of [11C]SL25.1188. Complementary arterial blood sampling was acquired. Radioactivity was quickly eliminated from plasma with 80% of parent compound remaining at 90 minutes. Metabolites were more polar than the parent compound. Time-activity curves showed high brain uptake, early peak and washout rate consistent with known regional MAO-B concentration. A two-tissue compartment model (2-TCM) provided better fits to the data than a 1-TCM. Measurement of total distribution volume ( VT) showed very good identifiability (based on coefficient of variation (COV)) for all regions of interest (ROIs) (COV( VT)<8%), low between-subject variability (˜20%), and quick temporal convergence (within 5% of final value at 45 minutes). Logan graphical method produces very good estimation of VT. Regional VT highly correlated with previous postmortem report of MAO-B level ( r2 = ≤0.9). Specific binding would account from 70% to 90% of VT. Hence, VT measurement of [11C]SL25.1 188 PET is an excellent estimation of MAO-B concentration.

scholarly journals 18F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging

2020 ◽  
pp. jnumed.120.244400 ◽  
Author(s):  
Ryuichi Harada ◽  
Yoshimi Hayakawa ◽  
Michinori Ezura ◽  
Pradith Lerdsirisuk ◽  
Yiqing Du ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Emission Tomography ◽  
Monoamine Oxidase B ◽  
Positron Emission Tomography Tracer ◽  
Positron Emission
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