Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives

Barbara Cosimelli; Elda Severi; Ettore Novellino; Anna Cavaccini; Mauro Cataldi; Roberta Budriesi; Matteo Micucci; Alberto Chiarini; Pierfranco Ioan

doi:10.1021/jm200414s

Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm200414s ◽

2011 ◽

Vol 54 (15) ◽

pp. 5597-5601 ◽

Cited By ~ 2

Author(s):

Barbara Cosimelli ◽

Elda Severi ◽

Ettore Novellino ◽

Anna Cavaccini ◽

Mauro Cataldi ◽

...

Keyword(s):

Calcium Channel ◽

Preliminary Finding ◽

Entry Blocker

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Calcium-Channel Entry Blocker Therapy for Hypertensive Patients with Concomitant Renal Impairment: A Focus on Isradipine

The Journal of Clinical Pharmacology ◽

10.1002/j.1552-4604.1994.tb04727.x ◽

1994 ◽

Vol 34 (12) ◽

pp. 1164-1172 ◽

Cited By ~ 2

Author(s):

William H. Frishman

Keyword(s):

Renal Impairment ◽

Calcium Channel ◽

Blocker Therapy ◽

Hypertensive Patients ◽

Entry Blocker

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1634: Increased Expression of Low Voltage-Activated T-Type (Alpha-Lg) and not L-Type (Alpha-Lc) Calcium Channel is Responsible for Down-Regulating Cgmp in Human Cavernosal Cells During Hyperglycemia

The Journal of Urology ◽

10.1016/s0022-5347(18)38842-6 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 432-432

Author(s):

Suresh Sikka ◽

Xiangbin Zeng ◽

Brian Keyser ◽

Wayne J.G. Hellstrom ◽

Ming Li

Keyword(s):

Calcium Channel ◽

Low Voltage

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1609: Sildenafil Does Not Reverse Hyperglycemia-Induced Expression of the Low Voltage-Activated T-Type (Alpha-1g) Calcium Channel that is Responsible for Down-Regulation of the Nitric Oxide-Cgmp Pathway

The Journal of Urology ◽

10.1016/s0022-5347(18)38817-7 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 425-425

Author(s):

Suresh Sikka ◽

Xiangbin Zeng ◽

Anshiya Ramanitharan ◽

Ming Li ◽

Wayne J.G. Hellstrom

Keyword(s):

Nitric Oxide ◽

Calcium Channel ◽

Low Voltage ◽

Down Regulation ◽

Induced Expression ◽

Cgmp Pathway

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Effects of sodium and calcium channel blockade on cytosolic calcium oscillations and phasic contractions of myometrial tissue

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)00015-4 ◽

1997 ◽

Vol 4 (2) ◽

pp. 72-77 ◽

Cited By ~ 6

Author(s):

M PHILLIPPE ◽

A BASA

Keyword(s):

Calcium Channel ◽

Cytosolic Calcium ◽

Calcium Oscillations ◽

Channel Blockade ◽

Calcium Channel Blockade

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Voltage-Gated calcium channel currents in pregnant human myometrial smooth muscle cells and their inhibition by iniomethacin

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86673-7 ◽

1998 ◽

Vol 5 (1) ◽

pp. 185A-185A

Author(s):

G KNOCK ◽

S SMIRNOV ◽

P AARONSON

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Calcium Channel ◽

Muscle Cells ◽

Voltage Gated ◽

Voltage Gated Calcium Channel ◽

Channel Currents

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386 Calcium channel blockers influence on T wave alternans

EP Europace ◽

10.1016/s1099-5129(05)80243-0 ◽

2005 ◽

Vol 7 ◽

pp. 82-82

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blockers ◽

T Wave ◽

T Wave Alternans

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Preliminary finding from a new device for monitoring performance and environmental factors in the field

PsycEXTRA Dataset ◽

10.1037/e445382005-001 ◽

2000 ◽

Cited By ~ 1

Author(s):

Harris R. Lieberman ◽

Bryan P. Coffey

Keyword(s):

Environmental Factors ◽

Preliminary Finding ◽

New Device ◽

Monitoring Performance

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Calcium channel, voltage-dependent, alpha2/delta 1 subunit

AfCS-Nature Molecule Pages ◽

10.1038/mp.a000429.01 ◽

2006 ◽

Author(s):

Franz Hofmann

Keyword(s):

Calcium Channel ◽

Voltage Dependent

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Calcium channel, voltage-dependent, alpha2/delta 3 subunit

AfCS-Nature Molecule Pages ◽

10.1038/mp.a000428.01 ◽

2006 ◽

Author(s):

Franz Hofmann

Keyword(s):

Calcium Channel ◽

Voltage Dependent

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P2914 The L-type calcium channel inhibitor diltiazem prevents diastolic dysfunction and stress-induced cardiac decompensation in a mouse model of familial hypertrophic cardiomyopathy

European Heart Journal ◽

10.1016/s0195-668x(03)95692-2 ◽

2003 ◽

Vol 24 (5) ◽

pp. 561

Author(s):

C TSCHOEPE

Keyword(s):

Hypertrophic Cardiomyopathy ◽

Mouse Model ◽

Calcium Channel ◽

Diastolic Dysfunction ◽

Familial Hypertrophic Cardiomyopathy ◽

Cardiac Decompensation

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