Books of InterestEmerging Drugs and Targets for Alzheimer’s Disease. Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Edited by Ana Martinez Royal Society of Chemistry, Cambridge, U.K. 2010. xxiv + 317 pp. 16 × 24 cm. ISBN 978-1-84973-063-1. $249.00.Emerging Drugs and Targets for Alzheimer’s Disease. Volume 2: Neuronal Plasticity, Neuronal Protection and Other Miscellaneous Strategies. Edited by Ana Martinez Royal Society of Chemistry, Cambridge, U.K. 2010. xxiv + 301 pp. 16 × 24 cm. ISBN 978-1-84973-064-8. $249.00.Biopharmaceuticals in Plants. Toward the Next Century of Medicine. By Kathleen Laura Hefferon CRC Press, Boca Raton, FL. 2010. xvii + 206 pp. 16 × 24 cm. ISBN 13 978-1-4398-0474-2. $99.95.GPCR Molecular Pharmacology and Drug Targeting. Edited by Annette Gilchrist Wiley, Hoboken, NJ. 2010. xxi + 520 pp. 16 × 24 cm. ISBN 978-0-470-30778-6. $149.95.Drug Development Perspectives. Considerations, Challenges, and Strategies. Edited by Nuggehally R. Srinivas HNB Publishing, New York, NY. 2010. x + 326 pp. 16 × 24 cm. ISBN 978-0-9664286-9-8. $99.75.Chemoinformatics and Computational Chemical Biology. Edited by Jürgen Bajorath Humana Press/Springer Science, New York, NY. 2010. x + 588 pp. 18.5 × 26 cm. ISBN 978-1-60761-838-6. $159.00.Functional Molecules from Natural Sources. Edited by Stephen K. Wrigley , Robert Thomas , Colin T. Bedford , and Neville Nicholson Royal Society of Chemistry, Cambridge, U.K. 2011. x + 233 pp. 16 × 24 cm. ISBN 978-1-84755-259-4. £109.99.

2011 ◽  
Vol 54 (9) ◽  
pp. 3450-3450
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
New York ◽  
Tau Protein ◽  
Neuronal Plasticity ◽  
Royal Society ◽  
Drug Targeting ◽  
Chemical Biology ◽  
Molecular Pharmacology ◽  
Neuronal Protection

Targeting Tau Hyperphosphorylation via Kinase Inhibition: Strategy to Address Alzheimer's Disease

2020 ◽  
Vol 20 (12) ◽  
pp. 1059-1073 ◽  
Author(s):  
Ahmad Abu Turab Naqvi ◽  
Gulam Mustafa Hasan ◽  
Md. Imtaiyaz Hassan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Glycogen Synthase ◽  
Paired Helical Filaments ◽  
Tau Hyperphosphorylation ◽  
Microtubule Stabilization ◽  
Extracellular Signal

Microtubule-associated protein tau is involved in the tubulin binding leading to microtubule stabilization in neuronal cells which is essential for stabilization of neuron cytoskeleton. The regulation of tau activity is accommodated by several kinases which phosphorylate tau protein on specific sites. In pathological conditions, abnormal activity of tau kinases such as glycogen synthase kinase-3 β (GSK3β), cyclin-dependent kinase 5 (CDK5), c-Jun N-terminal kinases (JNKs), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and microtubule affinity regulating kinase (MARK) lead to tau hyperphosphorylation. Hyperphosphorylation of tau protein leads to aggregation of tau into paired helical filaments like structures which are major constituents of neurofibrillary tangles, a hallmark of Alzheimer’s disease. In this review, we discuss various tau protein kinases and their association with tau hyperphosphorylation. We also discuss various strategies and the advancements made in the area of Alzheimer's disease drug development by designing effective and specific inhibitors for such kinases using traditional in vitro/in vivo methods and state of the art in silico techniques.

scholarly journals A current view on Tau protein phosphorylation in Alzheimer's disease

2021 ◽  
Vol 69 ◽  
pp. 131-138
Author(s):  
Susanne Wegmann ◽  
Jacek Biernat ◽  
Eckhard Mandelkow
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Phosphorylation ◽  
Tau Protein ◽  
Current View ◽  
A Current

Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients

The Lancet ◽  
1994 ◽  
Vol 343 (8904) ◽  
pp. 993-997 ◽  
Author(s):  
C.R. Harrington ◽  
C.M. Wischik ◽  
F.K. McArthur ◽  
G.A. Taylor ◽  
J.A. Edwardson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Renal Dialysis ◽  
Protein Processing ◽  
Dialysis Patients ◽  
Aluminium Accumulation

Effect of Alzheimer’s Training on Multicultural Personal Care Aides

2008 ◽  
Vol 9 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Robin C. Fenley ◽  
Sarah J. Bober ◽  
Mebane E. Powell ◽  
Jacquelin Berman ◽  
Barbara N. Altman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
New York ◽  
New York City ◽  
York City ◽  
The United States ◽  
Personal Care ◽  
Entry Level ◽  
Before And After ◽  
Item Knowledge

This article reports on the first 2 years of an ongoing project that examined the efficacy of a 10-hour dementia training provided to entry-level personal care aide (PCA) trainees from the Hispanic, White, African American, and Asian communities in New York City. Participants were enrolled in a 90-hour PCA training program offered by the New York City Department for the Aging and were either recipients of public assistance, displaced employees from September 11, or recent immigrants to the United States from China. Classes were conducted in Spanish, English, and Mandarin/Cantonese. An 11-item Knowledge of Alzheimer’s Disease instrument was developed for the purposes of this project and administered before and after the dementia training and at 3 months following graduation. All groups, regardless of language, showed a significant increase in knowledge of Alzheimer’s disease at the conclusion of the training and retention of this knowledge at 3 months follow-up. Age was strongly correlated with an increase in knowledge, while gender and education were not.

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