Phase Transitions in Oleic Acid and in Human Breast Tissue As Studied by Raman Spectroscopy and Raman Imaging

2011 ◽  
Vol 54 (9) ◽  
pp. 3386-3392 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Joanna Jablonska-Gajewicz ◽  
Radzislaw Kordek ◽  
Halina Abramczyk
Keyword(s):  
Raman Spectroscopy ◽  
Oleic Acid ◽  
Phase Transitions ◽  
Breast Tissue ◽  
Raman Imaging ◽  
Human Breast ◽  
Human Breast Tissue

scholarly journals Human breast tissue cancer diagnosis by Raman spectroscopy

2008 ◽  
Vol 22 (2-3) ◽  
pp. 113-121 ◽  
Author(s):  
H. Abramczyk ◽  
I. Placek ◽  
B. Brozek-Pluska ◽  
K. Kurczewski ◽  
Z. Morawiec ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Diagnosis ◽  
Breast Tissue ◽  
Breast Cancers ◽  
Human Breast ◽  
Human Breast Tissue ◽  
The World ◽  
Tissue Abnormalities ◽  
Time Diagnosis ◽  
Tissue Cancer

Differences between Raman spectra of normal, malignant and benign tissues have been recorded and analyzed as a method for the early detection of cancer. To the best of our knowledge, this is one of the most statistically reliable research (67 patients) on Raman spectroscopy-based diagnosis of breast cancers among the world women population. The paper demonstrates that Raman spectroscopy is a promising new tool for real-time diagnosis of tissue abnormalities.

Development of a new diagnostic Raman method for monitoring epigenetic modifications in the cancer cells of human breast tissue

2016 ◽  
Vol 8 (48) ◽  
pp. 8542-8553 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Monika Kopeć ◽  
Halina Abramczyk
Keyword(s):  
Cancer Cells ◽  
Breast Tissue ◽  
Epigenetic Modifications ◽  
Raman Imaging ◽  
Human Breast ◽  
Human Breast Tissue

Raman imaging can ‘upgrade’ cancer epigenetic tests and answer many questions by monitoring the biochemistry of cancer cells.

FT-Raman spectroscopy study of human breast tissue

2004 ◽  
Author(s):  
Renata A. Bitar Carter ◽  
Airton A. Martin ◽  
Mario M. Netto ◽  
Fernando A. Soares
Keyword(s):  
Raman Spectroscopy ◽  
Breast Tissue ◽  
Spectroscopy Study ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Ft Raman Spectroscopy ◽  
Ft Raman

Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue

2006 ◽  
Vol 13 (2) ◽  
pp. 617-628 ◽  
Author(s):  
C L Wilson ◽  
A H Sims ◽  
A Howell ◽  
C J Miller ◽  
R B Clarke
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Proliferation ◽  
Breast Tissue ◽  
Epithelial Cell Proliferation ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Tissue Microenvironment ◽  
Normal Human Breast ◽  
Normal Human

Oestrogen (E) is essential for normal and cancer development in the breast, while anti-oestrogens have been shown to reduce the risk of the disease. However, little is known about the effect of E on gene expression in the normal human breast, particularly when the epithelium and stroma are intact. Previous expression profiles of the response to E have been performed on tumour cell lines, in the absence of stroma. We investigated gene expression in normal human breast tissue transplanted into 9–10-week-old female athymic nude (Balb/c nu/nu) mice. After 2 weeks, when epithelial proliferation is minimal, one-third of the mice were treated with 17β-oestradiol (E2) to give human luteal-phase levels in the mouse, which we have previously shown to induce maximal epithelial cell proliferation. RNA was isolated from treated and untreated mice, labelled and hybridized to Affymetrix HG-U133A (human) GeneChips. Gene expression levels were generated using BioConductor implementations of the RMA and MAS5 algorithms. E2 treatment was found to represent the largest source of variation in gene expression and cross-species hybridization of mouse RNA from xenograft samples was demonstrated to be negligible. Known E2-responsive genes (such as TFF1 and AREG), and genes thought to be involved in breast cancer metastasis (including mammoglobin, KRT19 and AGR2), were upregulated in response to E treatment. Genes known to be co-expressed with E receptor α in breast cancer cell lines and tumours were both upregulated (XBP-1 and GREB1) and downregulated (RARRES1 and GATA3). In addition, genes that are normally expressed in the myoepithelium and extracellular matrix that maintain the tissue microenvironment were also differentially expressed. This suggests that the response to oestrogen in normal breast is highly dependent upon epithelial–stromal/myoepithelial interactions which maintain the tissue microenvironment during epithelial cell proliferation.

Quantitative determination of water-soluble scavengers in neoplastic and non-neoplastic human breast tissue

1988 ◽  
Vol 41 (5) ◽  
pp. 690-694 ◽  
Author(s):  
C. G. Honegger ◽  
J. Torhorst ◽  
H. Langemann ◽  
A. Kabiersch ◽  
W. Krenger
Keyword(s):  
Quantitative Determination ◽  
Breast Tissue ◽  
Water Soluble ◽  
Human Breast ◽  
Human Breast Tissue
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