scholarly journals Design, Synthesis, and Evaluation of Coumarin-Based Molecular Probes for Imaging of Myelination

2011 ◽  
Vol 54 (7) ◽  
pp. 2331-2340 ◽  
Author(s):  
Changning Wang ◽  
Chunying Wu ◽  
Junqing Zhu ◽  
Robert H. Miller ◽  
Yanming Wang
Keyword(s):  
Molecular Probes ◽  
Design Synthesis

Recent endeavors on design, synthesis, fluorescence mechanisms and applications of benzazole-based molecular probes toward miscellaneous species

2020 ◽  
Vol 175 ◽  
pp. 108157 ◽  
Author(s):  
Si-Hong Chen ◽  
Kai Jiang ◽  
Ying Xiao ◽  
Xi-Ying Cao ◽  
Mani Arulkumar ◽  
...  
Keyword(s):  
Molecular Probes ◽  
Design Synthesis

Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes

2005 ◽  
Vol 7 (23) ◽  
pp. 5199-5202 ◽  
Author(s):  
Amos B. Smith ◽  
Paul V. Rucker ◽  
Ignacio Brouard ◽  
B. Scott Freeze ◽  
Shujun Xia ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Molecular Probes ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis, and evaluation, derivatives of the fat-accumulation inhibitor ternatin: toward ternatin molecular probes

2014 ◽  
Vol 55 (32) ◽  
pp. 4445-4447 ◽  
Author(s):  
Yoshinori Kawazoe ◽  
Yoko Tanaka ◽  
Sachikazu Omura ◽  
Daisuke Uemura
Keyword(s):  
Molecular Probes ◽  
Design Synthesis ◽  
Fat Accumulation ◽  
Derivatives Of

scholarly journals Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Katharina Reeh ◽  
Peter A. Summers ◽  
Ian R. Gould ◽  
Rudiger Woscholski ◽  
Ramon Vilar
Keyword(s):  
Computational Study ◽  
Binding Mode ◽  
Molecular Probes ◽  
Membrane Phospholipids ◽  
Design Synthesis ◽  
Guest Binding ◽  
Wide Range ◽  
Free Environment ◽  
Small Molecule Receptors ◽  
Phosphatidylinositol Phosphates

Abstract Phosphatidylinositol phosphates (PIPs) are membrane phospholipids that play crucial roles in a wide range of cellular processes. Their function is dictated by the number and positions of the phosphate groups in the inositol ring (with seven different PIPs being active in the cell). Therefore, there is significant interest in developing small-molecule receptors that can bind selectively to these species and in doing so affect their cellular function or be the basis for molecular probes. However, to date there are very few examples of such molecular receptors. Towards this aim, herein we report a novel tripodal molecule that acts as receptor for mono- and bis-phosphorylated PIPs in a cell free environment. To assess their affinity to PIPs we have developed a new cell free assay based on the ability of the receptor to prevent alkaline phosphatase from hydrolysing these substrates. The new receptor displays selectivity towards two out of the seven PIPs, namely PI(3)P and PI(3,4)P2. To rationalise these results, a DFT computational study was performed which corroborated the experimental results and provided insight into the host–guest binding mode.

γ‑AApeptides as a New Class of Peptidomimetics: Design, Synthesis, and Applications

2021 ◽  
Vol 21 ◽  
Author(s):  
Ma Su ◽  
Yifan Zhu ◽  
Wei Wang ◽  
Feng Liu ◽  
Huanqiu Li
Keyword(s):  
Self Assembly ◽  
Combinatorial Library ◽  
Hierarchical Structures ◽  
Molecular Probes ◽  
Library Screening ◽  
Host Defense Peptides ◽  
Design Synthesis ◽  
Human Immuno Deficiency Virus ◽  
New Class ◽  
Spectrum Activity

: Peptidomimetics are studied for medicinal application because of its ability to mimic hierarchical structures of peptides and proteins. To break the limitation and expand the peptidomimetics family, a new class of peptidomimetics based on peptide nucleic acids (PNAs) backbone - “γ-AApeptides” was developed. Compared with previous peptidomimetics, γ-AApeptides possess prominent advantages such as resistance to proteolytic degradation, enhanced chemodiversity, good selectivity and outstanding bioactivity. The synthesis of γ-AApeptides is using a ‘‘monomer building block’’ strategy which is facile and efficient. γ-AApeptides are able to mimic primary and secondary structures of therapeutic peptides which make them promising candidates for molecular probes and potential drug leads. In the past decade, several interesting structures and applications of γ-AApeptides have been developed by different approaches such as structure-based design, combinatorial library screening, and peptides self-assembly and folding. By following the mechanism of host-defense peptides (HDPs), antibiotic γ-AApeptides showed broad-spectrum activity. At the same time, γ-AApeptides can be used for combinatorial library screening because of their structural stability and their chemodiversity. Anti-cancer agents, anti-T2DM (Type 2 diabetes mellitus) agents, anti-HIV (human immuno-deficiency virus) agents and anti-Alzheimer’s disease agents were developed by combinatorial screening and rational deign. Furthermore, γ-AApeptides as biopolymers, nanomaterials, supramolecular structures and self-assembly architectures were studied due to their unique backbone structures. Therefore, γ-AApeptides may play an important role in the development of peptidomimetics.

scholarly journals Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

2015 ◽  
Vol 11 ◽  
pp. 659-667 ◽  
Author(s):  
Mathieu L Lepage ◽  
Antoine Mirloup ◽  
Manon Ripoll ◽  
Fabien Stauffert ◽  
Anne Bodlenner ◽  
...  
Keyword(s):  
Protein Misfolding ◽  
Gaucher Disease ◽  
Photophysical Properties ◽  
Genetic Diseases ◽  
Molecular Probes ◽  
Design Synthesis ◽  
Pharmacological Chaperones ◽  
Rare Genetic Diseases ◽  
Photochemical Properties ◽  
Fluorescent Analogues

The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Variable Temperature ◽  
Inverse Temperature ◽  
Temperature Transition ◽  
Scanning Calorimetry ◽  
Design Synthesis ◽  
Inverse Temperature Transition ◽  
Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

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