Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors

Fuchun Xie; Hongbing Zhao; Dewen Li; Hong Chen; Haitian Quan; Xiaojing Shi; Liguang Lou; Youhong Hu

doi:10.1021/jm101388d

Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm101388d ◽

2011 ◽

Vol 54 (9) ◽

pp. 3200-3205 ◽

Cited By ~ 22

Author(s):

Fuchun Xie ◽

Hongbing Zhao ◽

Dewen Li ◽

Hong Chen ◽

Haitian Quan ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.09.004 ◽

2017 ◽

Vol 25 (21) ◽

pp. 5939-5951 ◽

Cited By ~ 6

Author(s):

Li Zhu ◽

Kaixiu Luo ◽

Ke Li ◽

Yi Jin ◽

Jun Lin

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm500849z ◽

2014 ◽

Vol 57 (19) ◽

pp. 7977-7989 ◽

Cited By ~ 32

Author(s):

Zhuang Yang ◽

Wenshuang Wu ◽

Jingjing Wang ◽

Li Liu ◽

Luyuan Li ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

ChemInform Abstract: Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent.

ChemInform ◽

10.1002/chin.200224130 ◽

2010 ◽

Vol 33 (24) ◽

pp. no-no

Author(s):

Qun Li ◽

et al. et al.

Keyword(s):

Antitumor Agent ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Orally Active ◽

Synthesis And Biological Evaluation

Download Full-text

Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.05.029 ◽

2014 ◽

Vol 22 (15) ◽

pp. 4285-4292 ◽

Cited By ~ 9

Author(s):

Yong Yin ◽

Fang Qiao ◽

Lu-Yi Jiang ◽

She-Feng Wang ◽

Shao Sha ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.11.047 ◽

2013 ◽

Vol 21 (3) ◽

pp. 632-642 ◽

Cited By ~ 18

Author(s):

Xiao-Feng Wang ◽

Emika Ohkoshi ◽

Sheng-Biao Wang ◽

Ernest Hamel ◽

Kenneth F. Bastow ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.02.002 ◽

2013 ◽

Vol 21 (21) ◽

pp. 6844-6854 ◽

Cited By ~ 38

Author(s):

Guangcheng Wang ◽

Fei Peng ◽

Dong Cao ◽

Zhuang Yang ◽

Xiaolei Han ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)00759-4 ◽

2002 ◽

Vol 12 (3) ◽

pp. 465-469 ◽

Cited By ~ 81

Author(s):

Qun Li ◽

Keith W. Woods ◽

Akiyo Claiborne ◽

Stephen L. Gwaltney, II ◽

Kenneth J. Barr ◽

...

Keyword(s):

Antitumor Agent ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

New Class ◽

Tubulin Polymerization Inhibitors ◽

Orally Active ◽

Synthesis And Biological Evaluation

Download Full-text

Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors

International Journal of Molecular Sciences ◽

10.3390/ijms160510173 ◽

2015 ◽

Vol 16 (12) ◽

pp. 10173-10184 ◽

Cited By ~ 1

Author(s):

Ling Zhang ◽

Yunlong Song ◽

Jingjing Huang ◽

Jia Liu ◽

Wenwen Zhu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Design, Synthesis and Biological Evaluation of Novel Acridine and Quinoline Derivatives as Tubulin Polymerization Inhibitors with Anticancer Activities

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116376 ◽

2021 ◽

pp. 116376

Author(s):

Yichang Ren ◽

Yong Ruan ◽

Binbin Cheng ◽

Ling Li ◽

Jin Liu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Quinoline Derivatives ◽

Anticancer Activities ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.11.010 ◽

2018 ◽

Vol 143 ◽

pp. 216-231 ◽

Cited By ~ 23

Author(s):

P.V. Sri Ramya ◽

Lalita Guntuku ◽

Srinivas Angapelly ◽

Chander Singh Digwal ◽

Uppu Jaya Lakshmi ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text