Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity

2010 ◽  
Vol 53 (22) ◽  
pp. 8202-8206 ◽  
Author(s):  
Peter Gibbons ◽  
Edite Verissimo ◽  
Nuna C. Araujo ◽  
Victoria Barton ◽  
Gemma L. Nixon ◽  
...  
Keyword(s):  
Combination Chemotherapy ◽  
Chemical Entity ◽  
Single Chemical

scholarly journals Chiral Polythiophenes: Part I: Syntheses of Monomeric Precursors

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4205
Author(s):  
Dorota Krasowska ◽  
Rafał Karpowicz ◽  
Józef Drabowicz
Keyword(s):  
Thin Layer ◽  
Chemical Entity ◽  
Single Chemical ◽  
Synthetic Approaches

The purpose of this mini-review is to comprehensively present the synthetic approaches used for the preparation of non-racemic mono- and multi-substituted thiophenes, which, in turn, can be applied as precursors for the synthesis of chiral polythiophenes isolated as a single chemical entity or having supramolecular thin-layer architectures.

scholarly journals Scaffold hybridization strategy towards potent hydroxamate-based inhibitors ofFlaviviridaeviruses andTrypanosomaspecies

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 991-1006 ◽  
Author(s):  
Erofili Giannakopoulou ◽  
Vasiliki Pardali ◽  
Efseveia Frakolaki ◽  
Vasileios Siozos ◽  
Vassilios Myrianthopoulos ◽  
...  
Keyword(s):  
Chemical Entity ◽  
Design And Synthesis ◽  
Single Chemical

Design and synthesis of potent inhibitors with dual activity by successfully merging two distinct scaffolds into a single chemical entity.

Single Chemical Entity Legal Highs: Assessing the Risk for Long Term Harm

2012 ◽  
Vol 5 (4) ◽  
pp. 304-319 ◽  
Author(s):  
Carolyn B. McNabb ◽  
Bruce R. Russell ◽  
Daniele Caprioli ◽  
David J. Nutt ◽  
Simon Gibbons ◽  
...  
Keyword(s):  
Chemical Entity ◽  
Legal Highs ◽  
Single Chemical

scholarly journals A divergent route towards single-chemical entity triazine dendrimers with opportunities for structural diversity

2007 ◽  
Vol 31 (7) ◽  
pp. 1283 ◽  
Author(s):  
Hannah Crampton ◽  
Emily Hollink ◽  
Lisa M. Perez ◽  
Eric E. Simanek
Keyword(s):  
Structural Diversity ◽  
Chemical Entity ◽  
Single Chemical

Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

2011 ◽  
Vol 21 (9) ◽  
pp. 2655-2658 ◽  
Author(s):  
Maria Laura Bolognesi ◽  
Manuela Bartolini ◽  
Andrea Tarozzi ◽  
Fabiana Morroni ◽  
Federica Lizzi ◽  
...  
Keyword(s):  
Chemical Entity ◽  
Single Chemical

Evaluations of Combination Chemotherapy(DAC-Tam) for Advanced Malignant Melanoma. Possible Patient Groups which may Show a Good Response Rate.

2001 ◽  
Vol 63 (5) ◽  
pp. 561-568
Author(s):  
Hideki KAMIYA ◽  
Hiroyuki KANOH ◽  
Naoki ICHIHASHI ◽  
Yoshiro ICHIKI ◽  
Hajime TAKAGI ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Combination Chemotherapy ◽  
Response Rate ◽  
Good Response Rate ◽  
Advanced Malignant Melanoma ◽  
Patient Groups
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