Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

2010 ◽  
Vol 53 (15) ◽  
pp. 5738-5748 ◽  
Author(s):  
Janne Weisell ◽  
Mervi T. Hyvönen ◽  
Merja R. Häkkinen ◽  
Nikolay A. Grigorenko ◽  
Marko Pietilä ◽  
...  
Keyword(s):  
Biological Characterization ◽  
Spermine Analogues

Identification, molecular and biological characterization of two novel secovirids in wild grass species in Belgium

2021 ◽  
Vol 298 ◽  
pp. 198397
Author(s):  
François J. Maclot ◽  
Virginie Debue ◽  
Arnaud G. Blouin ◽  
Núria Fontdevila Pareta ◽  
Lucie Tamisier ◽  
...  
Keyword(s):  
Grass Species ◽  
Biological Characterization ◽  
Wild Grass

Molecular and biological characterization of soybean yellow mottle mosaic virus severe strain infecting soybean in India

3 Biotech ◽  
2021 ◽  
Vol 11 (8) ◽  
Author(s):  
Nagamani Sandra ◽  
Ankita Tripathi ◽  
S. K. Lal ◽  
Bikash Mandal ◽  
Rakesh Kumar Jain
Keyword(s):  
Mosaic Virus ◽  
Biological Characterization ◽  
Severe Strain ◽  
Yellow Mottle

scholarly journals Molecular and biological characterization of influenza A viruses isolated from human fecal samples

2021 ◽  
pp. 104972
Author(s):  
Hebah A. Al Khatib ◽  
Peter V. Coyle ◽  
Muna A. Al Maslamani ◽  
Asmaa A. Al Thani ◽  
Sameer A. Pathan ◽  
...  
Keyword(s):  
Influenza A ◽  
Biological Characterization ◽  
Influenza A Viruses ◽  
Fecal Samples

Biochemical and biological characterization of the Hypanus americanus mucus: A perspective on stingray immunity and toxins

2019 ◽  
Vol 93 ◽  
pp. 832-840 ◽  
Author(s):  
Guilherme Rabelo Coelho ◽  
Pedro Prezotto Neto ◽  
Fernanda Cortinhas Barbosa ◽  
Rafael Silva Dos Santos ◽  
Patrícia Brigatte ◽  
...  
Keyword(s):  
Biological Characterization

scholarly journals Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 667 ◽  
Author(s):  
Carolina Proaño-Bolaños ◽  
Ailín Blasco-Zúñiga ◽  
José Rafael Almeida ◽  
Lei Wang ◽  
Miguel Angel Llumiquinga ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Structural Diversity ◽  
Biologically Active ◽  
Biological Characterization ◽  
Skin Secretion ◽  
Peptide Profile ◽  
Active Chemical ◽  
Molecular Masses ◽  
Skin Secretions

Frog skin secretions contain medically-valuable molecules, which are useful for the discovery of new biopharmaceuticals. The peptide profile of the skin secretion of Agalychnis spurrelli has not been investigated; therefore, the structural and biological characterization of its compounds signify an inestimable opportunity to acquire new biologically-active chemical scaffolds. In this work, skin secretion from this amphibian was analysed by molecular cloning and tandem mass spectrometry. Although the extent of this work was not exhaustive, eleven skin secretion peptides belonging to five peptide families were identified. Among these, we report the occurrence of two phyllokinins, and one medusin-SP which were previously reported in other related species. In addition, eight novel peptides were identified, including four dermaseptins, DRS-SP2 to DRS-SP5, one phylloseptin-SP1, and three orphan peptides. Phylloseptin-SP1 and dermaseptins-SP2 were identified in HPLC fractions based on their molecular masses determined by MALDI-TOF MS. Among the antimicrobial peptides, dermaseptin-SP2 was the most potent, inhibiting Escherichia coli, Staphylococcus aureus, and ORSA with a minimum inhibitory concentration (MIC) of 2.68 μM, and Candida albicans with an MIC of 10.71 μM, without haemolytic effects. The peptides described in this study represent but a superficial glance at the considerable structural diversity of bioactive peptides produced in the skin secretion of A. spurrelli.

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