Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1:  Improving the Pharmacokinetic Profile Using the Structure−Property Relationship

2007 ◽  
Vol 50 (19) ◽  
pp. 4572-4584 ◽  
Author(s):  
Jean-François Bonfanti ◽  
Frédéric Doublet ◽  
Jérôme Fortin ◽  
Jean Lacrampe ◽  
Jérôme Guillemont ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Pharmacokinetic Profile ◽  
Fusion Inhibitor ◽  
Structure Property ◽  
Property Relationship ◽  
Virus Fusion ◽  
Structure Property Relationship ◽  
Syncytial Virus ◽  
Selection Of ◽  
Clinical Candidate

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

2008 ◽  
Vol 51 (4) ◽  
pp. 875-896 ◽  
Author(s):  
Jean-François Bonfanti ◽  
Christophe Meyer ◽  
Frédéric Doublet ◽  
Jérôme Fortin ◽  
Philippe Muller ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Inhibitor ◽  
Virus Fusion ◽  
Syncytial Virus ◽  
Selection Of ◽  
Clinical Candidate

scholarly journals Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Dirk Roymans ◽  
Sarhad S Alnajjar ◽  
Michael B Battles ◽  
Panchan Sitthicharoenchai ◽  
Polina Furmanova-Hollenstein ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Therapeutic Efficacy ◽  
Fusion Inhibitor ◽  
Virus Fusion ◽  
Syncytial Virus

scholarly journals Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model

2010 ◽  
Vol 38 (2) ◽  
pp. 401-408 ◽  
Author(s):  
W. Olszewska ◽  
G. Ispas ◽  
C. Schnoeller ◽  
D. Sawant ◽  
T. Van de Casteele ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Mouse Model ◽  
Fusion Inhibitor ◽  
Protective Activity ◽  
Virus Fusion ◽  
Syncytial Virus

Exploration of Bis(Arylimidazole) Iridium Picolinate Complexes

2017 ◽  
Author(s):  
Aron Huckaba ◽  
sadig aghazada ◽  
iwan zimmermann ◽  
giulia grancini ◽  
natalia gasilova ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Photophysical Properties ◽  
Structure Property ◽  
Aryl Group ◽  
Ligand Modification ◽  
Property Relationship ◽  
Structure Property Relationship

The straightforward synthesis and photophysical properties of a new series of heteroleptic Iridium (III) bis(2-arylimidazole) picolinate complexes is reported. Each complex has been characterized by NMR, UV-Vis, cyclic voltammetry, and the emissive properties of each is described. By systematically modifying first the cyclometallating aryl group on the arylimidazole ligand and then the picolinate ligand, the ramifications of ligand modification in these complexes was better understood through the construction of a structure-property relationship.

Exploration of Bis(Arylimidazole) Iridium Picolinate Complexes

2017 ◽  
Author(s):  
Aron Huckaba ◽  
sadig aghazada ◽  
iwan zimmermann ◽  
giulia grancini ◽  
natalia gasilova ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Photophysical Properties ◽  
Structure Property ◽  
Aryl Group ◽  
Ligand Modification ◽  
Property Relationship ◽  
Structure Property Relationship

The straightforward synthesis and photophysical properties of a new series of heteroleptic Iridium (III) bis(2-arylimidazole) picolinate complexes is reported. Each complex has been characterized by NMR, UV-Vis, cyclic voltammetry, and the emissive properties of each is described. By systematically modifying first the cyclometallating aryl group on the arylimidazole ligand and then the picolinate ligand, the ramifications of ligand modification in these complexes was better understood through the construction of a structure-property relationship.

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