Small Molecule Designed to Target Metal Binding Site in the α2I Domain Inhibits Integrin Function

Jarmo Käpylä; Olli T. Pentikäinen; Tommi Nyrönen; Liisa Nissinen; Sanna Lassander; Johanna Jokinen; Matti Lahti; Anne Marjamäki; Mark S. Johnson; Jyrki Heino

doi:10.1021/jm070063t

Small Molecule Designed to Target Metal Binding Site in the α2I Domain Inhibits Integrin Function

Journal of Medicinal Chemistry ◽

10.1021/jm070063t ◽

2007 ◽

Vol 50 (11) ◽

pp. 2742-2746 ◽

Cited By ~ 18

Author(s):

Jarmo Käpylä ◽

Olli T. Pentikäinen ◽

Tommi Nyrönen ◽

Liisa Nissinen ◽

Sanna Lassander ◽

...

Keyword(s):

Binding Site ◽

Small Molecule ◽

Metal Binding ◽

Metal Binding Site ◽

Target Metal

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ChemInform Abstract: SMALL MOLECULE ANALOGS FOR THE SPECIFIC METAL-BINDING SITE OF LACTOFERRIN. PART 2. PHENOLATO COMPLEXES OF COPPER(II) AND THE NATURE OF THE CHARGE-TRANSFER TRANSITION IN THE VISIBLE REGION

Chemischer Informationsdienst ◽

10.1002/chin.198146298 ◽

1981 ◽

Vol 12 (46) ◽

Author(s):

E. W. AINSCOUGH ◽

A. G. BINGHAM ◽

A. M. BRODIE ◽

J. M. HUSBANDS ◽

J. E. PLOWMAN

Keyword(s):

Charge Transfer ◽

Binding Site ◽

Small Molecule ◽

Metal Binding ◽

Visible Region ◽

Charge Transfer Transition ◽

Metal Binding Site ◽

Specific Metal

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Small molecule analogues for the specific metal-binding site of lactoferrin. Part 2. Phenolato-complexes of copper(II) and the nature of the charge-transfer transition in the visible region

Journal of the Chemical Society Dalton Transactions ◽

10.1039/dt9810001701 ◽

1981 ◽

pp. 1701 ◽

Cited By ~ 23

Author(s):

Eric W. Ainscough ◽

Alistair G. Bingham ◽

Andrew M. Brodie ◽

June M. Husbands ◽

Jeffrey E. Plowman

Keyword(s):

Charge Transfer ◽

Binding Site ◽

Small Molecule ◽

Metal Binding ◽

Visible Region ◽

Charge Transfer Transition ◽

Metal Binding Site ◽

Specific Metal

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Faculty Opinions recommendation of Nickel binding and [NiFe]-hydrogenase maturation by the metallochaperone SlyD with a single metal-binding site in Escherichia coli.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13960987.15418102 ◽

2012 ◽

Author(s):

Michael Maroney ◽

Crisjoe Joseph

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Metal Binding ◽

Metal Binding Site ◽

Hydrogenase Maturation ◽

Nickel Binding

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Unraveling the Substrate−Metal Binding Site of Ferrochelatase: An X-ray Absorption Spectroscopic Study†

Biochemistry ◽

10.1021/bi015814m ◽

2002 ◽

Vol 41 (15) ◽

pp. 4809-4818 ◽

Cited By ~ 35

Author(s):

Gloria C. Ferreira ◽

Ricardo Franco ◽

Arianna Mangravita ◽

Graham N. George

Keyword(s):

Spectroscopic Study ◽

Binding Site ◽

Metal Binding ◽

Metal Binding Site ◽

X Ray ◽

Substrate Metal ◽

X Ray Absorption

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Presence of endogenous calcium ion in horseradish peroxidase. Elucidation of metal-binding site by substitutions of divalent and lanthanide ions for calcium and use of metal-induced NMR (1H and 113Cd) resonances.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)67667-7 ◽

1986 ◽

Vol 261 (20) ◽

pp. 9391-9399 ◽

Cited By ~ 4

Author(s):

I Morishima ◽

M Kurono ◽

Y Shiro

Keyword(s):

Horseradish Peroxidase ◽

Binding Site ◽

Metal Binding ◽

Calcium Ion ◽

Lanthanide Ions ◽

Metal Binding Site

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Identification and partial characterization of a low affinity metal-binding site in the light chain of tetanus toxin.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50387-8 ◽

1992 ◽

Vol 267 (13) ◽

pp. 9053-9058

Author(s):

J.F. Wright ◽

M Pernollet ◽

A Reboul ◽

C Aude ◽

M.G. Colomb

Keyword(s):

Binding Site ◽

Light Chain ◽

Metal Binding ◽

Tetanus Toxin ◽

Partial Characterization ◽

Metal Binding Site

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Construction of an additional metal-binding site in human metallothionein-2

Journal of Bioscience and Bioengineering ◽

10.1263/jbb.101.354 ◽

2006 ◽

Vol 101 (4) ◽

pp. 354-360 ◽

Cited By ~ 2

Author(s):

Mitsutoshi Toyama ◽

Mariko Sasaki ◽

Noriaki Hirayama ◽

Yoshikatsu Murooka ◽

Mitsuo Yamashita

Keyword(s):

Binding Site ◽

Metal Binding ◽

Metal Binding Site

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Rate-accelerating metal ion effects on decarboxylation of α-keto acids by a thiazolium ton bearing a metal binding site

Journal of the Chemical Society Chemical Communications ◽

10.1039/c39910000373 ◽

1991 ◽

pp. 373-374

Author(s):

Tatsuya Nabeshima ◽

Kazuhiko Moriyama ◽

Yumihiko Yano

Keyword(s):

Binding Site ◽

Metal Binding ◽

Metal Ion ◽

Metal Binding Site ◽

Keto Acids ◽

Ion Effects ◽

Metal Ion Effects

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Infrared Spectra of Sewage Sludge Fractions: Evidence for an Amide Metal Binding Site

Soil Science Society of America Journal ◽

10.2136/sssaj1979.03615995004300050015x ◽

1979 ◽

Vol 43 (5) ◽

pp. 893-899 ◽

Cited By ~ 26

Author(s):

S. A. Boyd ◽

L. E. Sommers ◽

D. W. Nelson

Keyword(s):

Sewage Sludge ◽

Binding Site ◽

Infrared Spectra ◽

Metal Binding ◽

Metal Binding Site

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Silver co-ordination compounds with aliphatic nitriles containing amino nitrogen as H bond donor or additional metal binding site: formation of a ring, a chain, a polymeric sheet and a 3D polymeric channeled structure

CrystEngComm ◽

10.1039/b206467g ◽

2002 ◽

Vol 4 (78) ◽

pp. 472 ◽

Cited By ~ 7

Author(s):

Andrea Erxleben

Keyword(s):

Binding Site ◽

Metal Binding ◽

Amino Nitrogen ◽

Site Formation ◽

Metal Binding Site ◽

Aliphatic Nitriles ◽

A Chain

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