scholarly journals Quantitative Conformationally Sampled Pharmacophore for δ Opioid Ligands:  Reevaluation of Hydrophobic Moieties Essential for Biological Activity

2007 ◽  
Vol 50 (8) ◽  
pp. 1799-1809 ◽  
Author(s):  
Denzil Bernard ◽  
Andrew Coop ◽  
Alexander D. MacKerell
Keyword(s):  
Biological Activity ◽  
Opioid Ligands ◽  
Conformationally Sampled Pharmacophore

Conformationally Sampled Pharmacophore for Peptidic δ Opioid Ligands

2005 ◽  
Vol 48 (24) ◽  
pp. 7773-7780 ◽  
Author(s):  
Denzil Bernard ◽  
Andrew Coop ◽  
Alexander D. MacKerell
Keyword(s):  
Opioid Ligands ◽  
Conformationally Sampled Pharmacophore

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions

Evaluation of biological activity of lignans extracted from tree knots

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
E Spilioti ◽  
B Holmbom ◽  
P Moutsatsou
Keyword(s):  
Biological Activity

Biological activity of Alpinia galanga root tubers

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
HRW Dharmaratne ◽  
BL Tekwani ◽  
M Jacob ◽  
NPD Nanayakkara
Keyword(s):  
Biological Activity ◽  
Alpinia Galanga

Synthesis and biological activity of some C(9)-hydroxymethyl-5,11-dimethylellipticine derivatives

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
N Mexia ◽  
S Michel ◽  
VPC Rocha ◽  
CS Meira ◽  
TS Macedo ◽  
...  
Keyword(s):  
Biological Activity
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