Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling

2006 ◽  
Vol 49 (19) ◽  
pp. 5759-5768 ◽  
Author(s):  
Rosalind H. Gunby ◽  
Shaheen Ahmed ◽  
Roberta Sottocornola ◽  
Marc Gasser ◽  
Sara Redaelli ◽  
...  
Keyword(s):  
Homology Modeling ◽  
Anaplastic Lymphoma Kinase ◽  
Binding Pocket ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Atp Binding ◽  
Inhibitor Binding ◽  
Anaplastic Lymphoma ◽  
Binding Analysis ◽  
Structural Insights

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

2009 ◽  
Vol 484 (1) ◽  
pp. 1-7 ◽  
Author(s):  
C. Gary Marshall ◽  
Maricel Torrent ◽  
Olusegun Williams ◽  
Kelly A. Hamilton ◽  
Carolyn A. Buser
Keyword(s):  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Inhibitor Binding ◽  
Kinesin Spindle Protein

Site-directed mutagenesis and homology modeling indicate an important role of cysteine 439 in the stability of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa

Biochimie ◽  
2005 ◽  
Vol 87 (12) ◽  
pp. 1056-1064 ◽  
Author(s):  
Lilian González-Segura ◽  
Roberto Velasco-García ◽  
Enrique Rudiño-Piñera ◽  
Carlos Mújica-Jiménez ◽  
Rosario A. Muñoz-Clares
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Homology Modeling ◽  
Aldehyde Dehydrogenase ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Betaine Aldehyde Dehydrogenase ◽  
Betaine Aldehyde ◽  
The Stability

Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis

1998 ◽  
Vol 256 (2) ◽  
pp. 310-316 ◽  
Author(s):  
Thomas C. Hohman ◽  
Ossama El-Kabbani ◽  
Michael S. Malamas ◽  
Kehdih Lai ◽  
Tatiana Putilina ◽  
...  
Keyword(s):  
Binding Site ◽  
Aldose Reductase ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Inhibitor Binding

Investigation of the ATP Binding Site ofEscherichia coliAminoimidazole Ribonucleotide Synthetase Using Affinity Labeling and Site-Directed Mutagenesis†

Biochemistry ◽  
1999 ◽  
Vol 38 (31) ◽  
pp. 9831-9839 ◽  
Author(s):  
E. J. Mueller ◽  
S. Oh ◽  
E. Kavalerchik ◽  
T. J. Kappock ◽  
E. Meyer ◽  
...  
Keyword(s):  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Affinity Labeling ◽  
Directed Mutagenesis ◽  
Atp Binding ◽  
Atp Binding Site

Active site analysis of cis-epoxysuccinate hydrolase from Nocardia tartaricans using homology modeling and site-directed mutagenesis

2011 ◽  
Vol 93 (6) ◽  
pp. 2377-2386 ◽  
Author(s):  
Vinayagam Vasu ◽  
Jayaraman Kumaresan ◽  
Manoharan Ganesh Babu ◽  
Sankaranarayanan Meenakshisundaram
Keyword(s):  
Homology Modeling ◽  
Active Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Site Analysis
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