Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia:  Synthesis and Structure−Activity Relationship

Donn G. Wishka; Daniel P. Walker; Karen M. Yates; Steven C. Reitz; Shaojuan Jia; Jason K. Myers; Kirk L. Olson; E. Jon Jacobsen; Mark L. Wolfe; Vincent E. Groppi; Alexander J. Hanchar; Bruce A. Thornburgh; Luz A. Cortes-Burgos; Erik H. F. Wong; Brian A. Staton; Thomas J. Raub; Nicole R. Higdon; Theron M. Wall; Raymond S. Hurst; Rodney R. Walters; William E. Hoffmann; Mihaly Hajos; Stanley Franklin; Galen Carey; Lisa H. Gold; Karen K. Cook; Steven B. Sands; Sabrina X. Zhao; John R. Soglia; Amit S. Kalgutkar; Stephen P. Arneric; Bruce N. Rogers

doi:10.1021/jm0602413

Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Journal of Medicinal Chemistry ◽

10.1021/jm0602413 ◽

2006 ◽

Vol 49 (14) ◽

pp. 4425-4436 ◽

Cited By ~ 141

Author(s):

Donn G. Wishka ◽

Daniel P. Walker ◽

Karen M. Yates ◽

Steven C. Reitz ◽

Shaojuan Jia ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cognitive Deficits ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Potential Treatment ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Structure Activity

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01569 ◽

2019 ◽

Vol 63 (3) ◽

pp. 944-960 ◽

Cited By ~ 4

Author(s):

Neelima Sinha ◽

Navnath P. Karche ◽

Mahip Kalyan Verma ◽

Sameer S. Walunj ◽

Prashant B. Nigade ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Structure Activity

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Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.09.019 ◽

2006 ◽

Vol 14 (24) ◽

pp. 8219-8248 ◽

Cited By ~ 63

Author(s):

Daniel P. Walker ◽

Donn G. Wishka ◽

David W. Piotrowski ◽

Shaojuan Jia ◽

Steven C. Reitz ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity

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Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor

European Journal of Biochemistry ◽

10.1046/j.1432-1327.2000.00971.x ◽

2000 ◽

Vol 267 (1) ◽

pp. 110-120 ◽

Cited By ~ 22

Author(s):

M. Gabriele Bixel ◽

Michael Krauss ◽

Ying Liu ◽

Maria L. Bolognesi ◽

Michela Rosini ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Structure Activity ◽

Polyamine Derivatives

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Ligands of Neuronal Nicotinic Acetylcholine Receptor (nAChR): Inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) Models

Current Medicinal Chemistry ◽

10.2174/0929867023371463 ◽

2002 ◽

Vol 9 (1) ◽

pp. 1-29 ◽

Cited By ~ 13

Author(s):

O. Nicolotti ◽

M. Pellegrini-Calace ◽

C. Altomare ◽

A. Carotti ◽

A. Carrieri ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Quantitative Structure ◽

Nicotinic Acetylcholine ◽

Structure Activity ◽

Qsar Models

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Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists

Korean Journal of Physiology and Pharmacology ◽

10.4196/kjpp.2009.13.1.55 ◽

2009 ◽

Vol 13 (1) ◽

pp. 55

Author(s):

Eun Ae Kim ◽

Kyoung Chul Jung ◽

Uy Dong Sohn ◽

Chaeuk Im

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Structure Activity

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α-Conotoxin Vc1.1 Structure–Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00389 ◽

2019 ◽

Vol 10 (10) ◽

pp. 4328-4336 ◽

Cited By ~ 3

Author(s):

Xin Chu ◽

Han-Shen Tae ◽

Qingliang Xu ◽

Tao Jiang ◽

David J. Adams ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Side Chain ◽

Nicotinic Acetylcholine ◽

Structure Activity

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Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112669 ◽

2020 ◽

Vol 205 ◽

pp. 112669

Author(s):

Maria Chiara Pismataro ◽

Nicole A. Horenstein ◽

Clare Stokes ◽

Marta Quadri ◽

Marco De Amici ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Structure Activity

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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm070755h ◽

2007 ◽

Vol 50 (22) ◽

pp. 5493-5508 ◽

Cited By ~ 35

Author(s):

Jianguo Ji ◽

Michael R. Schrimpf ◽

Kevin B. Sippy ◽

William H. Bunnelle ◽

Tao Li ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Structure Activity ◽

Selective Agonists

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ChemInform Abstract: Synthesis and Structure-Activity Relationship of Novel Pyridyl Ethers for the Nicotinic Acetylcholine Receptor.

ChemInform ◽

10.1002/chin.200035121 ◽

2010 ◽

Vol 31 (35) ◽

pp. no-no

Author(s):

Jung Lee ◽

Coralie B. Davis ◽

Ralph A. Rivero ◽

Allen B. Reitz ◽

Richard P. Shank

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Structure Activity ◽

Relationship Of

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Synthesis and structure–activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)00168-2 ◽

2000 ◽

Vol 10 (10) ◽

pp. 1063-1066 ◽

Cited By ~ 15

Author(s):

Jung Lee ◽

Coralie B. Davis ◽

Ralph A. Rivero ◽

Allen B. Reitz ◽

Richard P. Shank

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Structure Activity ◽

Relationship Of

Download Full-text