Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4Integrin Receptor Antagonists

Yong Gong; J. Kent Barbay; Alexey B. Dyatkin; Tamara A. Miskowski; Edward S. Kimball; Stephen M. Prouty; M. Carolyn Fisher; Rosemary J. Santulli; Craig R. Schneider; Nathaniel H. Wallace; Scott A. Ballentine; William E. Hageman; John A. Masucci; Bruce E. Maryanoff; Bruce P. Damiano; Patricia Andrade-Gordon; Dennis J. Hlasta; Pamela J. Hornby; Wei He

doi:10.1021/jm060031q

Synthesis and Biological Evaluation of Novel Pyridazinone-Based α4Integrin Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm060031q ◽

2006 ◽

Vol 49 (11) ◽

pp. 3402-3411 ◽

Cited By ~ 27

Author(s):

Yong Gong ◽

J. Kent Barbay ◽

Alexey B. Dyatkin ◽

Tamara A. Miskowski ◽

Edward S. Kimball ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Journal of Medicinal Chemistry ◽

10.1021/jm3007323 ◽

2012 ◽

Vol 55 (19) ◽

pp. 8211-8224 ◽

Cited By ~ 82

Author(s):

José Luis Díaz ◽

Rosa Cuberes ◽

Joana Berrocal ◽

Montserrat Contijoch ◽

Ute Christmann ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Σ1 Receptor ◽

Synthesis And Biological Evaluation

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N-(2,7-Dimethyl-2-alkyl-2H-chromen-6-yl)sulfonamide derivatives as selective serotonin 5-HT6 receptor antagonists: design, synthesis, and biological evaluation

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131417 ◽

2021 ◽

pp. 131417

Author(s):

Aizhan Abdildinova ◽

Young Chang Kim ◽

Gee-Hyung Lee ◽

Woo-Kyu Park ◽

Heeyeong Cho ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Serotonin ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.011 ◽

2012 ◽

Vol 20 (15) ◽

pp. 4661-4667 ◽

Cited By ~ 18

Author(s):

Renren Bai ◽

Zhen Wei ◽

Jie Liu ◽

Weijia Xie ◽

Hequan Yao ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Endothelin A Receptor ◽

Endothelin A ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-019-02291-y ◽

2019 ◽

Vol 28 (3) ◽

pp. 380-386

Author(s):

Junze Dong ◽

Jingya Zhang ◽

Zilu Li ◽

Solomon Asnake ◽

Daoguang Zhang ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.014 ◽

2018 ◽

Vol 158 ◽

pp. 302-310 ◽

Cited By ~ 4

Author(s):

Jingjing Peng ◽

Lifen Zhao ◽

Lanlan Wang ◽

Hui Chen ◽

Yunguang Qiu ◽

...

Keyword(s):

Biological Evaluation ◽

P2y1 Receptor ◽

Receptor Antagonists ◽

Urea Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127236 ◽

2020 ◽

Vol 30 (13) ◽

pp. 127236

Author(s):

Guangchao He ◽

Qiao Song ◽

Junwei Wang ◽

Anhua Xu ◽

Kewen Peng ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.05.078 ◽

2017 ◽

Vol 27 (17) ◽

pp. 4212-4217 ◽

Cited By ~ 2

Author(s):

Kejing Lao ◽

Jie Sun ◽

Chong Wang ◽

Ying Wang ◽

Qidong You ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Amide Derivatives ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Synthesis and biological evaluation of novel phenothiazine derivatives as non-peptide arginine vasopressin V2 receptor antagonists

Chinese Chemical Letters ◽

10.1016/j.cclet.2015.01.022 ◽

2015 ◽

Vol 26 (5) ◽

pp. 627-630 ◽

Cited By ~ 2

Author(s):

Shuang Zhi ◽

Shuai Mu ◽

Ying Liu ◽

Min Gong ◽

Ping-Bao Wang ◽

...

Keyword(s):

Arginine Vasopressin ◽

Biological Evaluation ◽

Phenothiazine Derivatives ◽

Receptor Antagonists ◽

Vasopressin V2 Receptor ◽

V2 Receptor ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm061369n ◽

2007 ◽

Vol 50 (12) ◽

pp. 2779-2786 ◽

Cited By ~ 40

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Peg Davis ◽

Shou-wu Ma ◽

Edita Navratilova ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Neurokinin 1 Receptor ◽

Modified Peptides ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Novel Potent Substance P and Neurokinin A Receptor Antagonists. Conception, Synthesis and Biological Evaluation of Indolizine Derivatives.

ChemInform ◽

10.1002/chin.200249165 ◽

2010 ◽

Vol 33 (49) ◽

pp. no-no

Author(s):

Regis Millet ◽

Juozas Domarkas ◽

Benoit Rigo ◽

Laurence Goossens ◽

Jean-Francois Goossens ◽

...

Keyword(s):

Substance P ◽

Biological Evaluation ◽

Neurokinin A ◽

Receptor Antagonists ◽

Synthesis And Biological Evaluation

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