Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Siavosh Mahboobi; Andrea Uecker; Andreas Sellmer; Christophe Cénac; Heymo Höcher; Herwig Pongratz; Emerich Eichhorn; Harald Hufsky; Antje Trümpler; Marit Sicker; Florian Heidel; Thomas Fischer; Carol Stocking; Sigurd Elz; Frank-D. Böhmer; Stefan Dove

doi:10.1021/jm058033i

Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm058033i ◽

2006 ◽

Vol 49 (11) ◽

pp. 3101-3115 ◽

Cited By ~ 37

Author(s):

Siavosh Mahboobi ◽

Andrea Uecker ◽

Andreas Sellmer ◽

Christophe Cénac ◽

Heymo Höcher ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm980398y ◽

1998 ◽

Vol 41 (22) ◽

pp. 4365-4377 ◽

Cited By ~ 55

Author(s):

Diane H. Boschelli ◽

Zhipei Wu ◽

Sylvester R. Klutchko ◽

H. D. Hollis Showalter ◽

James M. Hamby ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Inhibitory Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Kinase Inhibitory Activity ◽

Receptor Tyrosine Kinase Inhibitors

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ChemInform Abstract: Tyrphostins. Part 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins.

ChemInform ◽

10.1002/chin.199637219 ◽

2010 ◽

Vol 27 (37) ◽

pp. no-no

Author(s):

A. GAZIT ◽

H. APP ◽

G. MCMAHON ◽

J. CHEN ◽

A. LEVITZKI ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Kinase Structure

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Inhibitors of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Cardiovascular Drug Reviews ◽

10.1111/j.1527-3466.1996.tb00320.x ◽

1996 ◽

Vol 14 (4) ◽

pp. 380-399 ◽

Cited By ~ 4

Author(s):

Glenda E. Bilder ◽

Camilo J. Rojas

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

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Platelet-Derived Growth Factor Receptor-Tyrosine Kinase Inhibitor, Imatinib, Is Effective for Treating Pulmonary Hypertension Induced by Pulmonary Tumor Thrombotic Microangiopathy

International Heart Journal ◽

10.1536/ihj.14-220 ◽

2015 ◽

Vol 56 (2) ◽

pp. 245-248 ◽

Cited By ~ 23

Author(s):

Shun Minatsuki ◽

Ichiro Miura ◽

Atsushi Yao ◽

Hiroyuki Abe ◽

Hironori Muraoka ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Receptor Tyrosine Kinase ◽

Thrombotic Microangiopathy ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Pulmonary Tumor

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Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C

Cellular Signalling ◽

10.1016/j.cellsig.2012.12.016 ◽

2013 ◽

Vol 25 (4) ◽

pp. 883-897 ◽

Cited By ~ 8

Author(s):

Hyun Jin Kwon ◽

Go-Eun Kim ◽

Yun Taek Lee ◽

Meong-Sook Jeong ◽

Insug Kang ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Signaling Pathways ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Downstream Signaling ◽

Compound C

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Inhibition of platelet‐derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation

The FASEB Journal ◽

10.1096/fasebj.11.13.9367346 ◽

1997 ◽

Vol 11 (13) ◽

pp. 1119-1126 ◽

Cited By ~ 94

Author(s):

Marukka Myllärniemi ◽

Lazaro Calderon ◽

Karl Lemström ◽

Elisabeth Buchdunger ◽

Pekka Häyry

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Growth Factor ◽

Tyrosine Kinase ◽

Smooth Muscle Cell ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Smooth Muscle Cell Migration ◽

Cell Migration And Proliferation

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Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase

Cancer Science ◽

10.1111/cas.12101 ◽

2013 ◽

Vol 104 (4) ◽

pp. 486-494 ◽

Cited By ~ 9

Author(s):

Yoshiko Awazu ◽

Akio Mizutani ◽

Yoshinori Nagase ◽

Shuntarou Tsuchiya ◽

Kazuhide Nakamura ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Selective Inhibitor ◽

Platelet Derived Growth Factor ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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N-GLUCURONIDATION OF THE PLATELET-DERIVED GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR 6,7-(DIMETHOXY-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)-(3-FLUORO-PHENYL)-AMINE BY HUMAN UDP-GLUCURONOSYLTRANSFERASES

Drug Metabolism and Disposition ◽

10.1124/dmd.106.009274 ◽

2006 ◽

Vol 34 (5) ◽

pp. 748-755 ◽

Cited By ~ 25

Author(s):

Z. Yan ◽

G. W. Caldwell ◽

D. Gauthier ◽

G. C. Leo ◽

J. Mei ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Receptor Tyrosine Kinase Inhibitor

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Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-12951

Transplantation Journal ◽

10.1097/00007890-200211150-00023 ◽

2002 ◽

Vol 74 (9) ◽

pp. 1335-1341 ◽

Cited By ~ 10

Author(s):

Matthias Karck ◽

Rolf Meliss ◽

Michael Hestermann ◽

Michael Mengel ◽

Klaus Pethig ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Local Delivery ◽

Platelet Derived Growth Factor ◽

Allograft Vasculopathy ◽

Aortic Allograft

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Inhibition of Platelet Derived Growth Factor Receptor Tyrosine Kinase by Intracisternal Imatinib does not Prevent Subarachnoid Hemorrhage Associated Vascular Proliferation or Cerebral Vasospasm

Journal of Neurosurgical Anesthesiology ◽

10.1097/01.ana.0000187713.09656.5b ◽

2005 ◽

Vol 17 (4) ◽

pp. 223-224

Author(s):

Lombard FW ◽

Boone MD ◽

Miller CA ◽

Niklason LE ◽

Borel CO

Keyword(s):

Subarachnoid Hemorrhage ◽

Growth Factor ◽

Tyrosine Kinase ◽

Cerebral Vasospasm ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Vascular Proliferation

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