Naphtho[1,2-d]isothiazole Acetic Acid Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors

2005 ◽  
Vol 48 (22) ◽  
pp. 6897-6907 ◽  
Author(s):  
Federico Da Settimo ◽  
Giampaolo Primofiore ◽  
Concettina La Motta ◽  
Stefania Sartini ◽  
Sabrina Taliani ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

ChemInform Abstract: Thermorubin and 2-Hydroxyphenyl Acetic Acid, Aldose Reductase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 27 (17) ◽  
pp. no-no
Author(s):  
K. HAYASHI ◽  
M. DOMBOU ◽  
M. SEKIYA ◽  
H. NAKAJIMA ◽  
T. FUJITA ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

scholarly journals Isatin Derivatives as a New Class of Aldose Reductase Inhibitors With Antioxidant Activity

2021 ◽  
Author(s):  
Wenchao Liu ◽  
Huan Chen ◽  
Xiaonan Zhang ◽  
Xin Zhang ◽  
Long Xu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Acetic Acid ◽  
Aldose Reductase ◽  
Acid Group ◽  
Docking Studies ◽  
Side Chain ◽  
New Class ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors ◽  
Isatin Derivatives

Abstract In this work, isatin was employed as the scaffold to design aldose reductase inhibitors with antioxidant activity. Most of the isatin derivatives were proved to be excellent in the inhibition of aldose reductase (ALR2) with IC 50 values at submicromolar level, and (E)-2-(5-(4-methoxystyryl)-2,3-dioxoindolin-1-yl) acetic acid (9g) was identified as the most effective with an IC 50 value of 0.015 μM. Moreover, compounds 9a-h with styryl side chains at the C5 position of isatin showed potent antioxidant activity. Particularly, the phenolic compound 9h demonstrated similar antioxidant activity with the well-known antioxidant Trolox. Structure-activity relationship and molecular docking studies showed that the acetic acid group at N1 and C5 p-hydroxystyryl side chain were the key structures to increase the aldose reductase inhibitory activity and antioxidant activity.

Acetic Acid Derivatives of 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide as a Novel Class of Potent Aldose Reductase Inhibitors

2010 ◽  
Vol 53 (23) ◽  
pp. 8330-8344 ◽  
Author(s):  
Xin Chen ◽  
Changjin Zhu ◽  
Fan Guo ◽  
Xiaowei Qiu ◽  
Yanchun Yang ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors ◽  
Derivatives Of

scholarly journals Thermorubin and 2-Hydroayphenyl Acetic Acid, Aldose Reductase Inhibitors.

1995 ◽  
Vol 48 (11) ◽  
pp. 1345-1346 ◽  
Author(s):  
KEN-ICHIRO HAYASHI ◽  
MUNEHIKO DOMBOU ◽  
MICHIE SEKIYA ◽  
HIROSHI NAKAJIMA ◽  
TOMOYUKI FUJITA ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

scholarly journals Novel and Potent Aldose Reductase Inhibitors: 4-Benzyl- and 4-(Benzothiazol-2-ylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-acetic Acid Derivatives.

1994 ◽  
Vol 42 (6) ◽  
pp. 1264-1271 ◽  
Author(s):  
Tomoji AOTSUKA ◽  
Hiroshi HOSONO ◽  
Toshio KURIHARA ◽  
Yoshiyuki NAKAMURA ◽  
Tetsuo MATSUI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors
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