scholarly journals Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of thesn-1 andsn-2 Carbonyl Functionality Reveals the Essential Role of thesn-1 Carbonyl at the Lipid Interface in the Binding of DAG-Lactones to Protein Kinase C

2005 ◽  
Vol 48 (18) ◽  
pp. 5738-5748 ◽  
Author(s):  
Ji-Hye Kang ◽  
Megan L. Peach ◽  
Yongmei Pu ◽  
Nancy E. Lewin ◽  
Marc C. Nicklaus ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Essential Role ◽  
Conformationally Constrained ◽  
Kinase C

Essential role of protein kinase C in morphine-induced rewarding memory

2012 ◽  
Vol 62 (2) ◽  
pp. 959-966 ◽  
Author(s):  
Xingjie Ping ◽  
Yaoying Ma ◽  
Yijing Li ◽  
Chong Qi ◽  
Xiaowei Sun ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Essential Role ◽  
Kinase C

Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits

2004 ◽  
Vol 286 (4) ◽  
pp. H1455-H1460 ◽  
Author(s):  
Anindita Das ◽  
Ramzi Ockaili ◽  
Fadi Salloum ◽  
Rakesh C. Kukreja
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Infarct Size ◽  
Essential Role ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Sildenafil Citrate ◽  
Risk Area ◽  
Kinase C

Sildenafil citrate (Viagra) is the most widely used pharmacological drug for treating erectile dysfunction in men. It has potent cardioprotective effects against ischemia-reperfusion injury via nitric oxide and opening of mitochondrial ATP-sensitive K+ channels. We further investigated the role of protein kinase C (PKC)-dependent signaling pathway in sildenafil-induced cardioprotection. Rabbits were treated (orally) with sildenafil citrate (1.4 mg/kg) 30 min before index ischemia for 30 min and reperfusion for 3 h. The PKC inhibitor chelerythrine (5 mg/kg iv) was given 5 min before sildenafil. Infarct size (% of risk area) reduced from 33.65 ± 2.17 in the vehicle (saline) group to 15.07 ± 0.63 in sildenafil-treated groups, a 45% reduction compared with vehicle (mean ± SE, P < 0.05). Chelerythrine abolished sildenafil-induced protection, as demonstrated by increase in infarct size to 31.14 ± 2.4 ( P < 0.05). Chelerythrine alone had an infarct size of 33.5 ± 2.5, which was not significantly different compared with DMSO-treated group (36.8 ± 1.7, P > 0.05). Western blot analysis demonstrated translocation of PKC-α, -θ, and -δ isoforms from cytosol to membrane after treatment with sildenafil. However, no change in the PKC-β and -ϵ isoforms was observed. These data provide direct evidence of an essential role of PKC, and potentially PKC-α, -θ, and -δ, in sildenafil-induced cardioprotection in the rabbit heart.

Role of protein kinase C in the regulation of steroidogenesis in the mouse Leydig cell

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S63-S64
Author(s):  
A. K. MUKHOPADHYAY ◽  
H. G. BOHNET
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Leydig Cell ◽  
Kinase C ◽  
Mouse Leydig Cell
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