Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. A Structure−Activity Relationship Investigation

Gabriella De Martino; Giuseppe La Regina; Alessandra Di Pasquali; Rino Ragno; Alberto Bergamini; Chiara Ciaprini; Anna Sinistro; Giovanni Maga; Emmanuele Crespan; Marino Artico; Romano Silvestri

doi:10.1021/jm050273a

Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. A Structure−Activity Relationship Investigation

Journal of Medicinal Chemistry ◽

10.1021/jm050273a ◽

2005 ◽

Vol 48 (13) ◽

pp. 4378-4388 ◽

Cited By ~ 36

Author(s):

Gabriella De Martino ◽

Giuseppe La Regina ◽

Alessandra Di Pasquali ◽

Rino Ragno ◽

Alberto Bergamini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Quantitative Structure-Activity Relationship Study of 2-arylsulfonyl-6-substituted Benzonitriles as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636021000010932 ◽

2002 ◽

Vol 17 (4) ◽

pp. 219-225 ◽

Cited By ~ 2

Author(s):

B.K. Sharma ◽

Rajendra Kumar ◽

P. Singh

Keyword(s):

Reverse Transcriptase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Study ◽

Hiv 1

Download Full-text

Discovery of potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I

Chemical Biology & Drug Design ◽

10.1111/cbdd.13429 ◽

2019 ◽

Vol 93 (4) ◽

pp. 430-437 ◽

Cited By ~ 5

Author(s):

Dongwei Kang ◽

Zhao Wang ◽

Meng Chen ◽

Da Feng ◽

Gaochan Wu ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

Download Full-text

Molecular docking and quantitative structure–activity relationship (QSAR) analyses of indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors

Medicinal Chemistry Research ◽

10.1007/s00044-013-0647-8 ◽

2013 ◽

Vol 23 (1) ◽

pp. 417-425 ◽

Cited By ~ 5

Author(s):

Vijay H. Masand ◽

Devidas T. Mahajan ◽

Taibi Ben Hadda ◽

Rahul D. Jawarkar ◽

Hemant Chavan ◽

...

Keyword(s):

Molecular Docking ◽

Reverse Transcriptase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm990095j ◽

1999 ◽

Vol 42 (20) ◽

pp. 4150-4160 ◽

Cited By ~ 47

Author(s):

Marita Högberg ◽

Christer Sahlberg ◽

Per Engelhardt ◽

Rolf Noréen ◽

Jussi Kangasmetsä ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

Download Full-text

Docking, molecular dynamics and quantitative structure-activity relationship studies for HEPTs and DABOs as HIV-1 reverse transcriptase inhibitors

Journal of Molecular Modeling ◽

10.1007/s00894-011-1236-8 ◽

2011 ◽

Vol 18 (5) ◽

pp. 2185-2198 ◽

Cited By ~ 23

Author(s):

Yating Mao ◽

Yan Li ◽

Ming Hao ◽

Shuwei Zhang ◽

Chunzhi Ai

Keyword(s):

Molecular Dynamics ◽

Reverse Transcriptase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure–activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.12.050 ◽

2008 ◽

Vol 16 (7) ◽

pp. 4160-4172 ◽

Cited By ~ 10

Author(s):

Sara Cesarini ◽

Andrea Spallarossa ◽

Angelo Ranise ◽

Paola Fossa ◽

Paolo La Colla ◽

...

Keyword(s):

Reverse Transcriptase ◽

Molecular Modelling ◽

Structure Activity Relationship ◽

Parallel Synthesis ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Parallel synthesis, molecular modelling and further structure–activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.10.032 ◽

2009 ◽

Vol 44 (5) ◽

pp. 2190-2201 ◽

Cited By ~ 14

Author(s):

Andrea Spallarossa ◽

Sara Cesarini ◽

Angelo Ranise ◽

Silvia Schenone ◽

Olga Bruno ◽

...

Keyword(s):

Reverse Transcriptase ◽

Molecular Modelling ◽

Structure Activity Relationship ◽

Parallel Synthesis ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues.

Journal of Medicinal Chemistry ◽

10.1021/jm990572y ◽

2000 ◽

Vol 43 (2) ◽

pp. 304-304 ◽

Cited By ~ 7

Author(s):

Marita Högberg ◽

Christer Sahlberg ◽

Per Engelhardt ◽

Rolf Noréen ◽

Jussi Kangasmetsä ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

Download Full-text

Parallel one-pot synthesis and structure–activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.05.010 ◽

2008 ◽

Vol 16 (12) ◽

pp. 6353-6363 ◽

Cited By ~ 11

Author(s):

Sara Cesarini ◽

Andrea Spallarossa ◽

Angelo Ranise ◽

Silvia Schenone ◽

Olga Bruno ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

One Pot ◽

One Pot Synthesis ◽

Structure Activity ◽

Relationship Study ◽

Hiv 1

Download Full-text

Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs

Journal of Medicinal Chemistry ◽

10.1021/jm950639r ◽

1996 ◽

Vol 39 (21) ◽

pp. 4261-4274 ◽

Cited By ~ 89

Author(s):

Amanda S. Cantrell ◽

Per Engelhardt ◽

Marita Högberg ◽

S. Richard Jaskunas ◽

Nils Gunnar Johansson ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

Download Full-text