Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Carolyn D. Dzierba; Amy G. Takvorian; Maria Rafalski; Padmaja Kasireddy-Polam; Harvey Wong; Thaddeus F. Molski; Ge Zhang; Yu-Wen Li; Snjezana Lelas; Yong Peng; John F. McElroy; Robert C. Zaczek; Rebecca A. Taub; Andrew P. Combs; Paul J. Gilligan; George L. Trainor

doi:10.1021/jm049737f

Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm049737f ◽

2004 ◽

Vol 47 (23) ◽

pp. 5783-5790 ◽

Cited By ~ 12

Author(s):

Carolyn D. Dzierba ◽

Amy G. Takvorian ◽

Maria Rafalski ◽

Padmaja Kasireddy-Polam ◽

Harvey Wong ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, Structure−Activity Relationships, and In Vivo Evaluation ofN3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm900301y ◽

2009 ◽

Vol 52 (14) ◽

pp. 4173-4191 ◽

Cited By ~ 24

Author(s):

Richard A. Hartz ◽

Vijay T. Ahuja ◽

Argyrios G. Arvanitis ◽

Maria Rafalski ◽

Eddy W. Yue ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

In Vivo Evaluation ◽

Structure Activity Relationships ◽

Crf1 Receptor ◽

Structure Activity

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.117 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3870-3873 ◽

Cited By ~ 14

Author(s):

Xiaojun Han ◽

Jodi A. Michne ◽

Sokhom S. Pin ◽

Kevin D. Burris ◽

Lynn A. Balanda ◽

...

Keyword(s):

Anxiolytic Activity ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of Medicinal Chemistry ◽

10.1021/jm0611410 ◽

2007 ◽

Vol 50 (9) ◽

pp. 2269-2272 ◽

Cited By ~ 4

Author(s):

Carolyn D. Dzierba ◽

Andrew J. Tebben ◽

Richard G. Wilde ◽

Amy G. Takvorian ◽

Maria Rafalski ◽

...

Keyword(s):

Computational Modeling ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and structure–activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.01.129 ◽

2010 ◽

Vol 20 (6) ◽

pp. 1890-1894 ◽

Cited By ~ 15

Author(s):

Richard A. Hartz ◽

Vijay T. Ahuja ◽

William D. Schmitz ◽

Thaddeus F. Molski ◽

Gail K. Mattson ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Crf1 Receptor ◽

Structure Activity

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Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm049339c ◽

2005 ◽

Vol 48 (5) ◽

pp. 1540-1549 ◽

Cited By ~ 16

Author(s):

Richard F. Lowe ◽

Jodene Nelson ◽

Trunghau N. Dang ◽

Paul D. Crowe ◽

Anil Pahuja ◽

...

Keyword(s):

Rational Design ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.09.028 ◽

2012 ◽

Vol 20 (22) ◽

pp. 6559-6578 ◽

Cited By ~ 7

Author(s):

Kunitoshi Takeda ◽

Taro Terauchi ◽

Minako Hashizume ◽

Kohdoh Shikata ◽

Ryota Taguchi ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, Structure—Activity Relationships, and Anxiolytic Activity of 7-Aryl-6,7-dihydroimidazoimidazole Corticotropin-Releasing Factor 1 Receptor Antagonists.

ChemInform ◽

10.1002/chin.200550121 ◽

2005 ◽

Vol 36 (50) ◽

Author(s):

Xiaojun Han ◽

Gene M. Dubowchik ◽

et al. et al.

Keyword(s):

Anxiolytic Activity ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.06.034 ◽

2012 ◽

Vol 22 (15) ◽

pp. 4986-4989 ◽

Cited By ~ 3

Author(s):

Carolyn D. Dzierba ◽

Thais M. Sielecki ◽

Argyrios G. Arvanitis ◽

Amy Galka ◽

Tricia L. Johnson ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Structure-Activity Relationships of 4,10-Dihydro-4-oxo-4HImidazo[ 1,2-a]Indeno[1,2-e]Pyrazine Derivatives: Highly Potent and Selective AMPA Receptor Antagonists with In Vivo Activity

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557043487411 ◽

2004 ◽

Vol 4 (2) ◽

pp. 123-140 ◽

Cited By ~ 4

Author(s):

Jean-Marie Stutzmann ◽

Marc Vuilhorgne ◽

Serge Mignani

Keyword(s):

Ampa Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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