Distance of Hydroxyl Functionality from the Quaternized Center Influence DNA Binding and in Vitro Gene Delivery Efficacies of Cationic Lipids with Hydroxyalkyl Headgroups

2004 ◽  
Vol 47 (23) ◽  
pp. 5721-5728 ◽  
Author(s):  
Yenugonda Venkata Mahidhar ◽  
Mukthavaram Rajesh ◽  
Sunkara Sakunthala Madhavendra ◽  
Arabinda Chaudhuri
Keyword(s):  
Dna Binding ◽  
Gene Delivery ◽  
Cationic Lipids

Synthesis and Evaluation of Cationic Lipids Bearing Cholesteryl Groups for Gene Delivery in vitro.

ChemInform ◽  
2003 ◽  
Vol 34 (7) ◽  
Author(s):  
Man-Zhou Zhu ◽  
Qi-Hua Wu ◽  
Guisheng Zhang ◽  
Tan Ren ◽  
Dexi Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids

Synthesis and in Vitro Evaluation of Glutamide-Containing Cationic Lipids for Gene Delivery

2006 ◽  
Vol 17 (6) ◽  
pp. 1530-1536 ◽  
Author(s):  
Vijaya Gopal ◽  
Tekkatte K. Prasad ◽  
Nalam M. Rao ◽  
Makoto Takafuji ◽  
Mohammed M. Rahman ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
In Vitro Evaluation

Synthesis and Evaluation of Cationic Lipids Bearing Cholesteryl Groups for Gene Delivery In Vitro

2002 ◽  
Vol 75 (10) ◽  
pp. 2207-2213 ◽  
Author(s):  
Man-Zhou Zhu ◽  
Qi-Hua Wu ◽  
Guisheng Zhang ◽  
Tan Ren ◽  
Dexi Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids

Synthesis and biological activity of carbamate-linked cationic lipids for gene delivery in vitro

2012 ◽  
Vol 22 (11) ◽  
pp. 3837-3841 ◽  
Author(s):  
Defu Zhi ◽  
Shubiao Zhang ◽  
Farooq Qureshi ◽  
Yinan Zhao ◽  
Shaohui Cui ◽  
...  
Keyword(s):  
Biological Activity ◽  
Gene Delivery ◽  
Cationic Lipids

Replacement of quaternary ammonium headgroups by tri-ornithine in cationic lipids for the improvement of gene delivery in vitro and in vivo

2017 ◽  
Vol 5 (39) ◽  
pp. 7963-7973 ◽  
Author(s):  
Y. N. Zhao ◽  
Y. Z. Piao ◽  
C. M. Zhang ◽  
Y. M. Jiang ◽  
A. Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Quaternary Ammonium ◽  
Cationic Lipids

Replacement of quaternary ammonium headgroups by tri-ornithine in lipids improved gene delivery in vitro and in vivo with little toxicity.

Cell Biological and Biophysical Aspects of Lipid-mediated Gene Delivery

2006 ◽  
Vol 26 (4) ◽  
pp. 301-324 ◽  
Author(s):  
N. Madhusudhana Rao ◽  
Vijaya Gopal
Keyword(s):  
Gene Delivery ◽  
Viral Vectors ◽  
First Generation ◽  
Cationic Lipid ◽  
Cationic Lipids ◽  
Biological Knowledge ◽  
Effective Strategies ◽  
Hydrophilic Region

Cationic lipids are conceptually and methodologically simple tools to deliver nucleic acids into the cells. Strategies based on cationic lipids are viable alternatives to viral vectors and are becoming increasingly popular owing to their minimal toxicity. The first-generation cationic lipids were built around the quaternary nitrogen primarily for binding and condensing DNA. A large number of lipids with variations in the hydrophobic and hydrophilic region were generated with excellent transfection efficiencies in vitro. These cationic lipids had reduced efficiencies when tested for gene delivery in vivo. Efforts in the last decade delineated the cell biological basis of the cationic lipid gene delivery to a significant detail. The application of techniques such as small angle X-ray spectroscopy (SAXS) and fluorescence microscopy, helped in linking the physical properties of lipid:DNA complex (lipoplex) with its intracellular fate. This biological knowledge has been incorporated in the design of the second-generation cationic lipids. Lipid-peptide conjugates (peptoids) are effective strategies to overcome the various cellular barriers along with the lipoplex formulations methodologies. In this context, cationic lipid-mediated gene delivery is considerably benefited by the methodologies of liposome-mediated drug delivery. Lipid mediated gene delivery has an intrinsic advantage of being a biomimetic platform on which considerable variations could be built to develop efficient in vivo gene delivery protocols.

ChemInform Abstract: Synthesis and Evaluation of Vitamin D-Based Cationic Lipids for Gene Delivery in vitro.

ChemInform ◽  
2010 ◽  
Vol 31 (36) ◽  
pp. no-no
Author(s):  
Tan Ren ◽  
Guisheng Zhang ◽  
Feng Liu ◽  
Dexi Liu
Keyword(s):  
Vitamin D ◽  
Gene Delivery ◽  
Cationic Lipids
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