Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS−Coronavirus

2005 ◽  
Vol 48 (4) ◽  
pp. 1256-1259 ◽  
Author(s):  
Gerold Hoever ◽  
Lidia Baltina ◽  
Martin Michaelis ◽  
Rimma Kondratenko ◽  
Lia Baltina ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Glycyrrhizic Acid ◽  
Sars Coronavirus

Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus

2021 ◽  
Vol 294 ◽  
pp. 198290
Author(s):  
Lidia A. Baltina ◽  
Mann-Jen Hour ◽  
Ya-Chi Liu ◽  
Young-Sheng Chang ◽  
Su-Hua Huang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antiviral Activity ◽  
Zika Virus ◽  
Glycyrrhizic Acid ◽  
Amino Acid Esters ◽  
Acid Esters

scholarly journals Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

2017 ◽  
Vol 43 (4) ◽  
pp. 456-462 ◽  
Author(s):  
A. I. Fayrushina ◽  
L. A. Baltina ◽  
L. A. Baltina ◽  
N. I. Konovalova ◽  
P. A. Petrova ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antiviral Activity ◽  
Glycyrrhizic Acid ◽  
Amino Acid Esters ◽  
Acid Esters

Antiviral activity of glycyrrhizic acid

1980 ◽  
Vol 36 (3) ◽  
pp. 304-304 ◽  
Author(s):  
R. Pompei ◽  
A. Pani ◽  
O. Flore ◽  
M. A. Marcialis ◽  
B. Loddo
Keyword(s):  
Antiviral Activity ◽  
Glycyrrhizic Acid

scholarly journals Antiviral Carbon Dots: Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms (Small 13/2020)

Small ◽  
2020 ◽  
Vol 16 (13) ◽  
pp. 2070068 ◽  
Author(s):  
Ting Tong ◽  
Hongwei Hu ◽  
Junwei Zhou ◽  
Shuangfei Deng ◽  
Xiaotong Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbon Dots ◽  
Glycyrrhizic Acid ◽  
High Antiviral Activity

scholarly journals Glycyrrhizic Acid Inhibits SARS-CoV-2 Infection by Blocking Spike Protein-Mediated Cell Attachment

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6090
Author(s):  
Jingjing Li ◽  
Dongge Xu ◽  
Lingling Wang ◽  
Mengyu Zhang ◽  
Guohai Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Glycyrrhizic Acid ◽  
Cell Attachment ◽  
Protein S ◽  
Host Cells ◽  
S Protein ◽  
Wide Range ◽  
Interaction Interface ◽  
Binding Pockets ◽  
Antiviral Activities

Glycyrrhizic acid (GA), also known as glycyrrhizin, is a triterpene glycoside isolated from plants of Glycyrrhiza species (licorice). GA possesses a wide range of pharmacological and antiviral activities against enveloped viruses including severe acute respiratory syndrome (SARS) virus. Since the S protein (S) mediates SARS coronavirus 2 (SARS-CoV-2) cell attachment and cell entry, we assayed the GA effect on SARS-CoV-2 infection using an S protein-pseudotyped lentivirus (Lenti-S). GA treatment dose-dependently blocked Lenti-S infection. We showed that incubation of Lenti-S virus, but not the host cells with GA prior to the infection, reduced Lenti-S infection, indicating that GA targeted the virus for infection. Surface plasmon resonance measurement showed that GA interacted with a recombinant S protein and blocked S protein binding to host cells. Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction. In addition to identifying GA antiviral activity against SARS-CoV-2, the study linked GA antiviral activity to its effect on virus cell binding.

scholarly journals Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Small ◽  
2020 ◽  
Vol 16 (13) ◽  
pp. 1906206 ◽  
Author(s):  
Ting Tong ◽  
Hongwei Hu ◽  
Junwei Zhou ◽  
Shuangfei Deng ◽  
Xiaotong Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbon Dots ◽  
Glycyrrhizic Acid ◽  
High Antiviral Activity

scholarly journals Antiviral Activity of Nucleoside Analogues against SARS-coronavirus (SARS-CoV)

2006 ◽  
Vol 17 (5) ◽  
pp. 285-289 ◽  
Author(s):  
Chung K Chu ◽  
Srinivas Gadthula ◽  
Xin Chen ◽  
Hyunah Choo ◽  
Sureyya Olgen ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Nucleoside Analogues ◽  
Sars Coronavirus

The Synthesis and Antiviral Activity of Glycyrrhizic Acid Conjugates with α-D-Glucosamine and Some Glycosylamines

2004 ◽  
Vol 30 (3) ◽  
pp. 275-282 ◽  
Author(s):  
R. M. Kondratenko ◽  
L. A. Baltina ◽  
S. R. Mustafina ◽  
E. V. Vasil'eva ◽  
R. Pompei ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Glycyrrhizic Acid
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