6,19-Sulfur-Bridged Progesterone Analogues with Antiimmunosuppressive Activity1

2005 ◽  
Vol 48 (18) ◽  
pp. 5675-5683 ◽  
Author(s):  
Adriana S. Veleiro ◽  
Adali Pecci ◽  
María C. Monteserín ◽  
Ricardo Baggio ◽  
María T. Garland ◽  
...  
Keyword(s):  
Progesterone Analogues

PROGESTATIONAL ACTIVITY OF STEREOISOMERIC PROGESTERONE-ANALOGUES FOLLOWING ORAL ADMINISTRATION IN AMENORRHOEA

1960 ◽  
Vol XXXV (II) ◽  
pp. 197-203 ◽  
Author(s):  
K.-G. Tillinger ◽  
E. Diczfalusy
Keyword(s):  
Side Effects ◽  
Oral Administration ◽  
Human Subject ◽  
Histological Appearance ◽  
Orally Active ◽  
Progesterone Analogues

ABSTRACT A stereoisomeric analogue of progesterone, 9β,10α-pregn-4-ene-3,20-dione (retro-progesterone) and a 6-dehydro derivative, 9β,10α-pregna-4,6-diene-3,20-dione (6-dehydro-retro-progesterone) were studied for their progestational activity in 26 artificial cycles induced in 17 amenorrhoic women.1 It was found that 6-dehydro-retro-progesterone is a highly potent orally active progestational agent in the human subject. Daily doses of 10 mg of this compound given orally for 10 days induced a definite secretory transformation of the endometrium. The histological appearance of the endometrium following treatment with this compound could not be distinguished from that seen in normal cycles. Both compounds studied were excellently tolerated; no toxic side-effects were observed.

Synthesis of 5-methyl-19-nor-5β-pregn-9-ene derivatives

1990 ◽  
Vol 55 (7) ◽  
pp. 1783-1791 ◽  
Author(s):  
Jiří Polman ◽  
Alexander Kasal
Keyword(s):  
Tributyltin Hydride ◽  
Progesterone Analogues

3β,5,6β-Trihydroxy-5α-pregnan-20-one 3-pivalate (I) was converted into 3β,6β-dihydroxy-5-methyl-19-nor-5β-pregn-9-en-20-one 3-pivalate 5-acetate (II) under conditions of Westphalen rearrangement. Deoxygenation in the position 6β was effected by treatment of the corresponding 6β-thiobenzoate or thioimidazolide with tributyltin hydride. Progesterone analogues XII and XIII, prepared from the 6-deoxy compound IX, exhibit abortive activity.

ChemInform Abstract: 17(13 → 18)-abeo-Pregnanes. Synthesis of Progesterone Analogues.

ChemInform ◽  
2010 ◽  
Vol 24 (49) ◽  
pp. no-no
Author(s):  
A. FERRARA ◽  
M. O. V. BENEDETTI ◽  
A. A. GHINI ◽  
G. BURTON
Keyword(s):  
Progesterone Analogues

Chromatographic data of progesterone analogues

1962 ◽  
Vol 8 ◽  
pp. 359-362 ◽  
Author(s):  
J.L. Swanson ◽  
J.C. Warren ◽  
C. Harris ◽  
H.A. Salhanick
Keyword(s):  
Chromatographic Data ◽  
Progesterone Analogues

scholarly journals Progesterone improves porcine in vitro fertilisation system

2014 ◽  
Vol 62 (1) ◽  
pp. 117-124
Author(s):  
Clara Malo ◽  
Lydia Gil ◽  
Rafael Cano ◽  
Felisa Martinez ◽  
Noelia Gonzalez
Keyword(s):  
Beneficial Effect ◽  
Developmental Competence ◽  
In Vitro Fertilisation ◽  
Nuclear Maturation ◽  
Embryo Cultures ◽  
System P ◽  
Late Maturation ◽  
Progesterone Analogues

In an effort to improve the quality of in vitro produced porcine embryos, the effect of progestagens — progesterone analogues — on the in vitro developmental competence of porcine oocytes was studied. A total of 1421 in vitro matured oocytes, from 4 replicates, were inseminated with frozen-thawed spermatozoa. Progestagens were added to late maturation and embryo cultures (10 IU/ml). Fertilisation success (pre-maturation, penetration, monospermy and efficiency) and nuclear maturation were evaluated. There were no differences among prematuration rates between groups (P = 0.221). Penetration rates were higher (P < 0.001) in the presence of progestagens (75.0%) as compared to the control (51.7%). However, no differences were observed in monospermy percentages (P = 0.246). The results indicated that supplementation with progestagens increased the efficiency of the in vitro fertilisation system (P < 0.001). An additional beneficial effect was observed in nuclear maturation with progestagens (P = 0.035). In summary, progestagen supplementation is an important factor to improve the in vitro fertilisation procedure.

scholarly journals Water-Soluble Progesterone Analogues Are Effective, Injectable Treatments in Animal Models of Traumatic Brain Injury

2012 ◽  
Vol 3 (5) ◽  
pp. 362-366 ◽  
Author(s):  
David B. Guthrie ◽  
Donald G. Stein ◽  
Dennis C. Liotta ◽  
Mark A. Lockwood ◽  
Iqbal Sayeed ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Animal Models ◽  
Water Soluble ◽  
Progesterone Analogues
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