Small Molecule Inhibitors of Dynamin I GTPase Activity:  Development of Dimeric Tyrphostins

Timothy Hill; Luke R. Odell; Jennifer K. Edwards; Mark E. Graham; Andrew B. McGeachie; Jenny Rusak; Annie Quan; Ruben Abagyan; Janet L. Scott; Phillip J. Robinson; Adam McCluskey

doi:10.1021/jm040208l

Small Molecule Inhibitors of Dynamin I GTPase Activity: Development of Dimeric Tyrphostins

Journal of Medicinal Chemistry ◽

10.1021/jm040208l ◽

2005 ◽

Vol 48 (24) ◽

pp. 7781-7788 ◽

Cited By ~ 49

Author(s):

Timothy Hill ◽

Luke R. Odell ◽

Jennifer K. Edwards ◽

Mark E. Graham ◽

Andrew B. McGeachie ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Gtpase Activity ◽

Dynamin I

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The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity

ACS Medicinal Chemistry Letters ◽

10.1021/ml200284s ◽

2012 ◽

Vol 3 (5) ◽

pp. 352-356 ◽

Cited By ~ 23

Author(s):

Mark J. Robertson ◽

Gordana Hadzic ◽

Joseph Ambrus ◽

D. Yuri Pomè ◽

Emily Hyde ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Gtpase Activity ◽

New Class

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From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Cited By ~ 1

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004750.54854 ◽

2002 ◽

Author(s):

Carol Otey

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Identification of small molecule inhibitors of anthrax lethal factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016978.201559 ◽

2004 ◽

Author(s):

Kristina Downing

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Lethal Factor ◽

Anthrax Lethal Factor

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Faculty Opinions recommendation of Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017973.285766 ◽

2005 ◽

Author(s):

George Perry

Keyword(s):

Small Molecule ◽

Amyloid Beta ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023153.264839 ◽

2005 ◽

Author(s):

Robert Kelley

Keyword(s):

T Cell ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

High Affinity

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Faculty Opinions recommendation of Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024840.292879 ◽

2005 ◽

Author(s):

Chandra Kumar

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phosphoinositide Dependent Kinase

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Faculty Opinions recommendation of Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1069767.522696 ◽

2007 ◽

Author(s):

Kim Barrett

Keyword(s):

Cystic Fibrosis ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

In Vivo Studies ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Regulator Protein ◽

Cystic Fibrosis Transmembrane

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Faculty Opinions recommendation of Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13411091.14784061 ◽

2011 ◽

Author(s):

Martin Stahl

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3462958.3157056 ◽

2010 ◽

Author(s):

Jim Maher

Keyword(s):

Small Molecule ◽

Rational Design ◽

Small Molecule Inhibitors ◽

Hiv Replication

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