Design and Synthesis of 3‘- and 5‘-O-(3-Benzenesulfonylfuroxan-4-yl)-2‘-deoxyuridines:  Biological Evaluation as Hybrid Nitric Oxide Donor−Nucleoside Anticancer Agents

2004 ◽  
Vol 47 (7) ◽  
pp. 1840-1846 ◽  
Author(s):  
Sameh Moharram ◽  
Aihua Zhou ◽  
Leonard I. Wiebe ◽  
Edward E. Knaus
Keyword(s):  
Nitric Oxide ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Nitric Oxide Donor ◽  
Design And Synthesis

Synthesis and Biological Evaluation of Nitric Oxide-Donating Thalidomide Analogues as Anticancer Agents

2009 ◽  
Vol 6 (4) ◽  
pp. 466-474 ◽  
Author(s):  
Tao Wang ◽  
Yi-Hua Zhang ◽  
Xiang-Wen Kong ◽  
Yi-Sheng Lai ◽  
Hui Ji ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals The synthesis, characterization and biological evaluation of a new nitric oxide donor agent

2014 ◽  
Vol 79 (4) ◽  
pp. 389-400 ◽  
Author(s):  
Lenuta Profire ◽  
Maria Apotrosoaei ◽  
Anca Oprea ◽  
Mihai Brebu ◽  
Florentina Lupascu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Weight Loss ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Nitric Oxide Donor ◽  
Biological Assays ◽  
Ft Ir ◽  
Anti Inflammatory ◽  
Tg And Dtg ◽  
Inflammatory Effect

The synthesis of a new xanthine nitric oxide donor (TSP-81) has been discussed. The designed compound includes two structural moieties - theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide) linked by the nitric oxide donor alkyl chain as a spacer. The compound has been characterized by microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR, UV-vis, TG and DTG. The thermal behaviour showed that TSP-81 melts with decomposition, in four steps, the most important ones being the 2nd one (the registered weight loss being 17.6 %) and the 3rd one (with a registered weight loss of 30.4 %). The toxicity degree, the anti-inflammatory effect and the ability of releasing nitric oxide of the TSP-81 have also been evaluated. The biological assays established that TSP-81 exhibits enhanced biological properties such as lower toxicity and higher anti-inflammatory effect in reference with theophylline and acetaminophen, the drugs used as parents molecules. The TSP-81 is approximately 2 times more active than theophylline and 4 times more active than acetaminophen in reducing cotton pellet-granuloma formation. Furthermore, the release of nitric oxide (NO) appears to have an important contribution to enhancing the anti-inflammatory effect.

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