Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

2004 ◽  
Vol 47 (3) ◽  
pp. 612-626 ◽  
Author(s):  
Le Wang ◽  
Gary T. Wang ◽  
Xilu Wang ◽  
Yunsong Tong ◽  
Gerry Sullivan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Farnesyltransferase Inhibitors ◽  
Design Synthesis

Design, Synthesis and Biological Activity of Aromatic Diketone Derivatives as HIV-1 Integrase Inhibitors

2015 ◽  
Vol 11 (2) ◽  
pp. 180-187 ◽  
Author(s):  
Liming Hu ◽  
Zhipeng Li ◽  
Zhanyang Wang ◽  
Gengxin Liu ◽  
Xianzhuo He ◽  
...  
Keyword(s):  
Biological Activity ◽  
Integrase Inhibitors ◽  
Design Synthesis ◽  
Hiv 1

scholarly journals Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

MedChemComm ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 1905-1909 ◽  
Author(s):  
Faustine d'Orchymont ◽  
Jeannine Hess ◽  
Gordana Panic ◽  
Marta Jakubaszek ◽  
Lea Gemperle ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antimalarial Drug ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Drug Candidates ◽  
Derivatives Of

The design, synthesis, characterization and biological evaluation of new ferrocenyl and ruthenocenyl derivatives of the antimalarial mefloquine is described.

1-Methyl-3H-pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis, and Biological Activity of New Antitumor Agents

2005 ◽  
Vol 48 (8) ◽  
pp. 2859-2866 ◽  
Author(s):  
Anna Maria Almerico ◽  
Francesco Mingoia ◽  
Patrizia Diana ◽  
Paola Barraja ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis

scholarly journals Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents

2015 ◽  
Vol 58 (19) ◽  
pp. 7749-7762 ◽  
Author(s):  
Yongseok Kwon ◽  
Jayoung Song ◽  
Honggu Lee ◽  
Eun-Yeong Kim ◽  
Kiho Lee ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
Orally Active

Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles

1997 ◽  
Vol 5 (3) ◽  
pp. 591-599 ◽  
Author(s):  
Hitoshi Hori ◽  
Cheng-Zhe Jin ◽  
Masatoshi Kiyono ◽  
Soko Kasai ◽  
Mariko Shimamura ◽  
...  
Keyword(s):  
Biological Activity ◽  
Hypoxic Cell ◽  
Design Synthesis

Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1932-1945 ◽  
Author(s):  
Xu Han ◽  
Yongying Shi ◽  
Longlong Si ◽  
Zibo Fan ◽  
Han Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Biological Activity ◽  
Sialic Acid ◽  
Virus Entry ◽  
Pentacyclic Triterpene ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Activity Evaluation ◽  
Virus Entry Inhibitors

A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.

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