Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors:  Synthesis, Structure−Activity Relationships, and Antitumor Activities ofN-Phenyl-N‘-{4-(4-quinolyloxy)phenyl}ureas

Kazuo Kubo; Toshiyuki Shimizu; Shin-ichi Ohyama; Hideko Murooka; Akemi Iwai; Kazuhide Nakamura; Kazumasa Hasegawa; Yoshiko Kobayashi; Noriko Takahashi; Kazumi Takahashi; Shinichiro Kato; Toshio Izawa; Toshiyuki Isoe

doi:10.1021/jm030427r

Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities ofN-Phenyl-N‘-{4-(4-quinolyloxy)phenyl}ureas

Journal of Medicinal Chemistry ◽

10.1021/jm030427r ◽

2005 ◽

Vol 48 (5) ◽

pp. 1359-1366 ◽

Cited By ~ 101

Author(s):

Kazuo Kubo ◽

Toshiyuki Shimizu ◽

Shin-ichi Ohyama ◽

Hideko Murooka ◽

Akemi Iwai ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Antitumor Activities ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm101036c ◽

2010 ◽

Vol 53 (22) ◽

pp. 8140-8149 ◽

Cited By ~ 33

Author(s):

Peng Cho Tang ◽

Yi Dong Su ◽

Jun Feng ◽

Jian Hong Fu ◽

Jiang Liang Yang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Antitumor Activities ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.02.025 ◽

2006 ◽

Vol 16 (10) ◽

pp. 2672-2676 ◽

Cited By ~ 20

Author(s):

Laurent F.A. Hennequin ◽

Peter Ballard ◽

F. Tom Boyle ◽

Bénédicte Delouvrié ◽

Rebecca P.A. Ellston ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Egf Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and Structure−Activity Relationships of Linear and Conformationally Constrained Peptide Analogues of CIYKYY as Src Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm060334k ◽

2006 ◽

Vol 49 (11) ◽

pp. 3395-3401 ◽

Cited By ~ 13

Author(s):

Anil Kumar ◽

Guofeng Ye ◽

Yuehao Wang ◽

Xiaofeng Lin ◽

Gongqin Sun ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Src Tyrosine Kinase ◽

Conformationally Constrained ◽

Structure Activity Relationships ◽

Structure Activity ◽

Peptide Analogues

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm970367n ◽

1997 ◽

Vol 40 (15) ◽

pp. 2296-2303 ◽

Cited By ~ 85

Author(s):

James M. Hamby ◽

Cleo J. C. Connolly ◽

Mel C. Schroeder ◽

R. Thomas Winters ◽

H. D. Hollis Showalter ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm011022e ◽

2002 ◽

Vol 45 (6) ◽

pp. 1300-1312 ◽

Cited By ~ 205

Author(s):

Laurent F. Hennequin ◽

Elaine S. E. Stokes ◽

Andrew P. Thomas ◽

Craig Johnstone ◽

Patrick A. Plé ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors

Oncology Reports ◽

10.3892/or.2018.6542 ◽

2018 ◽

Cited By ~ 4

Author(s):

Shuang Lai ◽

Jun‑Ning Chen ◽

Han‑Wei Huang ◽

Xiang‑Yu Zhang ◽

Hai‑Lun Jiang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 5. Synthesis and Structure-Activity Relationships for 4-((Phenylmethyl)amino)- and 4-(Phenylamino) quinazolines as Potent Adenosine 5′-Triphosphate Binding Site Inhibitors of the Tyrosine Kinase Domain

ChemInform ◽

10.1002/chin.199552154 ◽

2010 ◽

Vol 26 (52) ◽

pp. no-no

Author(s):

G. W. REWCASTLE ◽

W. A. DENNY ◽

A. J. BRIDGES ◽

H. ZHOU ◽

D. R. CODY ◽

...

Keyword(s):

Tyrosine Kinase ◽

Binding Site ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Kinase Domain ◽

Tyrosine Kinase Domain ◽

Structure Activity Relationships ◽

Structure Activity

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Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm960879m ◽

1997 ◽

Vol 40 (12) ◽

pp. 1820-1826 ◽

Cited By ~ 66

Author(s):

Gordon W. Rewcastle ◽

Alexander J. Bridges ◽

David W. Fry ◽

J. Ronald Rubin ◽

William A. Denny

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Epidermal Growth

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Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases

Journal of Medicinal Chemistry ◽

10.1021/jm00001a011 ◽

1995 ◽

Vol 38 (1) ◽

pp. 58-67 ◽

Cited By ~ 47

Author(s):

Brian D. Palmer ◽

Gordon W. Rewcastle ◽

Andrew M. Thompson ◽

Maruta Boyd ◽

H. D. Hollis Showalter ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Structure Activity Relationships ◽

Structure Activity ◽

In Vitro Inhibition ◽

Nonreceptor Protein Tyrosine Kinases

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Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships amongN- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparativein Vitroandin VivoStudies against Selected Sulfur Congeners

Journal of Medicinal Chemistry ◽

10.1021/jm960689b ◽

1997 ◽

Vol 40 (4) ◽

pp. 413-426 ◽

Cited By ~ 44

Author(s):

H. D. Hollis Showalter ◽

Anthony D. Sercel ◽

Boguslawa M. Leja ◽

Craig D. Wolfangel ◽

Linda A. Ambroso ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Protein Tyrosine ◽

Structure Activity Relationships ◽

Structure Activity

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