Synthesis, Structure−Activity Relationships, and Mechanism of Drug Resistance ofd- andl-β-3‘-Fluoro-2‘,3‘-unsaturated-4‘-thionucleosides as Anti-HIV Agents

2004 ◽  
Vol 47 (7) ◽  
pp. 1631-1640 ◽  
Author(s):  
Wei Zhu ◽  
Youhoon Chong ◽  
Hyunah Choo ◽  
Judy Mathews ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv

Synthesis, Structure−Activity Relationships, and Drug Resistance of β-d-3‘-Fluoro-2‘,3‘-Unsaturated Nucleosides as Anti-HIV Agents

2004 ◽  
Vol 47 (13) ◽  
pp. 3399-3408 ◽  
Author(s):  
Wen Zhou ◽  
Giuseppe Gumina ◽  
Youhoon Chong ◽  
Jianing Wang ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv

Design, synthesis, and structure–activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

2009 ◽  
Vol 17 (16) ◽  
pp. 5962-5967 ◽  
Author(s):  
Anna-Maria Monforte ◽  
Patrizia Logoteta ◽  
Stefania Ferro ◽  
Laura De Luca ◽  
Nunzio Iraci ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv

ChemInform Abstract: Structure-Activity Relationships of β-D-(2S,5R)- and α-D-( 2S,5S)-1,3-Oxathiolanyl Nucleosides as Potential Anti-HIV Agents.

ChemInform ◽  
2010 ◽  
Vol 24 (50) ◽  
pp. no-no
Author(s):  
L. S. JEONG ◽  
R. F. SCHINAZI ◽  
J. W. BEACH ◽  
H. O. KIM ◽  
K. SHANMUGANATHAN ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure ◽  
Anti Hiv Agents ◽  
Anti Hiv

ChemInform Abstract: Anti-AIDS Agents. Part 34. Synthesis and Structure-Activity Relationships of Betulin Derivatives as Anti-HIV Agents.

ChemInform ◽  
2010 ◽  
Vol 30 (11) ◽  
pp. no-no
Author(s):  
I-Chen Sun ◽  
Hui-Kang Wang ◽  
Yoshiki Kashiwada ◽  
Jing-Kang Shen ◽  
L. Mark Cosentino ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Betulin Derivatives

L-.beta.-(2S,4S)- and L-.alpha.-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships

1993 ◽  
Vol 36 (5) ◽  
pp. 519-528 ◽  
Author(s):  
Hea O. Kim ◽  
Raymond F. Schinazi ◽  
Kirupathevy Shanmuganathan ◽  
Lak S. Jeong ◽  
J. Warren Beach ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv

scholarly journals Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors

2006 ◽  
Vol 2006 ◽  
pp. 1-9 ◽  
Author(s):  
I. Kostova ◽  
S. Raleva ◽  
P. Genova ◽  
R. Argirova
Keyword(s):  
New Drugs ◽  
Hiv Protease ◽  
Hiv Integrase ◽  
Hiv Replication ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Rational Combination ◽  
Rt Inhibitors ◽  
Anti Hiv Agents ◽  
Anti Hiv

HIV/AIDS pandemics is a serious threat to health and development of mankind, and searching for effective anti-HIV agents remains actual. Considerable progress has been made in recent years in the field of drug development against HIV. A lot of structurally different coumarins were found to display potent anti-HIV activity. The current review demonstrates the variety of synthetic coumarins having unique mechanism of action referring to the different stages of HIV replication. Recent studies based on the account of various synthetic coumarins seem to indicate that some of them serve as potent non-nucleoside RT-inhibitors, another as inhibitors of HIV-integrase or HIV-protease. The merits of selecting potential anti-HIV agents to be used in rational combination drugs design and structure-activity relationships are discussed.The scientific community is looking actively for new drugs and combinations for treatment of HIV infection effective for first-line treatment, as well as against resistant mutants. The investigation on chemical anti-HIV agents gives hope and optimism about it. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives.

Anti-AIDS Agents. 34.†Synthesis and Structure−Activity Relationships of Betulin Derivatives as Anti-HIV Agents

1998 ◽  
Vol 41 (23) ◽  
pp. 4648-4657 ◽  
Author(s):  
I-Chen Sun ◽  
Hui-Kang Wang ◽  
Yoshiki Kashiwada ◽  
Jing-Kang Shen ◽  
L. Mark Cosentino ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Betulin Derivatives

Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review

2019 ◽  
Vol 181 ◽  
pp. 111566 ◽  
Author(s):  
Yu-Mei Huang ◽  
Njud S. Alharbi ◽  
Bing Sun ◽  
C.S. Shantharam ◽  
K.P. Rakesh ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Synthetic Routes ◽  
Anti Hiv Agents ◽  
Anti Hiv

Structure-activity relationships of .beta.-D-(2S,5R)- and .alpha.-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents

1993 ◽  
Vol 36 (18) ◽  
pp. 2627-2638 ◽  
Author(s):  
Lak S. Jeong ◽  
Raymond F. Schinazi ◽  
J. Warren Beach ◽  
Hea O. Kim ◽  
Kirupathevy Shanmuganathan ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Hiv Agents ◽  
Anti Hiv
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