N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Stacy W. Remiszewski; Lidia C. Sambucetti; Kenneth W. Bair; John Bontempo; David Cesarz; Nagarajan Chandramouli; Ru Chen; Min Cheung; Susan Cornell-Kennon; Karl Dean; George Diamantidis; Dennis France; Michael A. Green; Kobporn Lulu Howell; Rina Kashi; Paul Kwon; Peter Lassota; Mary S. Martin; Yin Mou; Lawrence B. Perez; Sushil Sharma; Troy Smith; Eric Sorensen; Francis Taplin; Nancy Trogani; Richard Versace; Heather Walker; Susan Weltchek-Engler; Alexander Wood; Arthur Wu; Peter Atadja

doi:10.1021/jm030235w

N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Journal of Medicinal Chemistry ◽

10.1021/jm030235w ◽

2003 ◽

Vol 46 (21) ◽

pp. 4609-4624 ◽

Cited By ~ 97

Author(s):

Stacy W. Remiszewski ◽

Lidia C. Sambucetti ◽

Kenneth W. Bair ◽

John Bontempo ◽

David Cesarz ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

In Vivo Antitumor Activity ◽

Activity Discovery ◽

Methyl Phenyl

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Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-4836 ◽

2008 ◽

Vol 14 (10) ◽

pp. 3113-3123 ◽

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Author(s):

Clifton Lee Dalgard ◽

Kurtis R. Van Quill ◽

Joan M. O'Brien

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

In Vivo Antitumor Activity

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Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.01.041 ◽

2009 ◽

Vol 19 (5) ◽

pp. 1403-1408 ◽

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Author(s):

Haishan Wang ◽

Niefang Yu ◽

Hongyan Song ◽

Dizhong Chen ◽

Yong Zou ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Design Synthesis ◽

Sar Studies ◽

In Vivo Antitumor Activity

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10.1093/annonc/mdv517.06 ◽

2015 ◽

Vol 26 ◽

pp. ix1

Author(s):

K. Saijo ◽

K. Narita ◽

T. Katoh ◽

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Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

In Vivo Antitumor Activity ◽

Phosphoinositide 3 Kinase

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Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.04.041 ◽

2010 ◽

Vol 20 (11) ◽

pp. 3314-3321 ◽

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Author(s):

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Ting Lu ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Straight Chain ◽

In Vivo Antitumor Activity

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.96.8.4592 ◽

1999 ◽

Vol 96 (8) ◽

pp. 4592-4597 ◽

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Author(s):

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T. Yamashita ◽

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...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Human Tumors ◽

Synthetic Inhibitor ◽

In Vivo Antitumor Activity

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Faculty Opinions recommendation of The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

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2016 ◽

Author(s):

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Keyword(s):

Antitumor Activity ◽

Antigen Receptors ◽

Chimeric Antigen Receptors ◽

In Vivo Antitumor Activity

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Chemischer Informationsdienst ◽

10.1002/chin.198305341 ◽

1983 ◽

Vol 14 (5) ◽

Author(s):

A. ROSOWSKY ◽

S.-H. KIM ◽

D. TRITES ◽

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Keyword(s):

Antitumor Activity ◽

In Vivo Antitumor Activity

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Chemischer Informationsdienst ◽

10.1002/chin.198449291 ◽

1984 ◽

Vol 15 (49) ◽

Author(s):

A. ROSOWSKY ◽

R. A. FORSCH ◽

J. H. FREISHEIM ◽

J. GALIVAN ◽

M. WICK

Keyword(s):

Antitumor Activity ◽

Dihydrofolate Reductase ◽

Degradation Products ◽

In Vivo Antitumor Activity

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Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.04.040 ◽

2014 ◽

Vol 74 ◽

pp. 742-750 ◽

Cited By ~ 57

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Chengyuan Liang ◽

Juan Xia ◽

Dong Lei ◽

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Qizheng Yao ◽

...

Keyword(s):

Schiff Base ◽

Antitumor Activity ◽

Schiff Base Derivatives ◽

In Vivo Antitumor Activity ◽

Derivatives Of

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10.1097/00001813-199701000-00012 ◽

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Vol 8 (1) ◽

pp. 88-91 ◽

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Keyword(s):

Antitumor Activity ◽

In Vivo Antitumor Activity ◽

Heterocyclic Derivatives ◽

Derivatives Of

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