Defining the Molecular Requirements for the Selective Delivery of Polyamine Conjugates into Cells Containing Active Polyamine Transporters

2003 ◽  
Vol 46 (24) ◽  
pp. 5129-5138 ◽  
Author(s):  
Chaojie Wang ◽  
Jean-Guy Delcros ◽  
Laura Cannon ◽  
Fanta Konate ◽  
Horacio Carias ◽  
...  
Keyword(s):  
Selective Delivery ◽  
Polyamine Conjugates

N1-Substituent Effects in the Selective Delivery of Polyamine Conjugates into Cells Containing Active Polyamine Transporters

2004 ◽  
Vol 47 (24) ◽  
pp. 6055-6069 ◽  
Author(s):  
Richard Andrew Gardner ◽  
Jean-Guy Delcros ◽  
Fanta Konate ◽  
Fred Breitbeil ◽  
Bénédicte Martin ◽  
...  
Keyword(s):  
Substituent Effects ◽  
Selective Delivery ◽  
Polyamine Conjugates

scholarly journals Delivery of Cinnamic Aldehyde Antioxidant Response Activating nanoParticles (ARAPas) for Vascular Applications

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 709
Author(s):  
Ana E. Cartaya ◽  
Halle Lutz ◽  
Sophie Maiocchi ◽  
Morgan Nalesnik ◽  
Edward M. Bahnson
Keyword(s):  
Ex Vivo ◽  
Antioxidant Response ◽  
Related Factor ◽  
Cinnamic Aldehyde ◽  
Vsmc Proliferation ◽  
Nrf2 Activation ◽  
Selective Delivery ◽  
And Migration ◽  
Inner Vessel ◽  
Macrophage Uptake

Selective delivery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators to the injured vasculature at the time of vascular surgical intervention has the potential to attenuate oxidative stress and decrease vascular smooth muscle cell (VSMC) hyperproliferation and migration towards the inner vessel wall. To this end, we developed a nanoformulation of cinnamic aldehyde (CA), termed Antioxidant Response Activating nanoParticles (ARAPas), that can be readily loaded into macrophages ex vivo. The CA-ARAPas-macrophage system was used to study the effects of CA on VSMC in culture. CA was encapsulated into a pluronic micelle that was readily loaded into both murine and human macrophages. CA-ARAPas inhibits VSMC proliferation and migration, and activates Nrf2. Macrophage-mediated transfer of CA-ARAPas to VSMC is evident after 12 h, and Nrf2 activation is apparent after 24 h. This is the first report, to the best of our knowledge, of CA encapsulation in pluronic micelles for macrophage-mediated delivery studies. The results of this study highlight the feasibility of CA encapsulation and subsequent macrophage uptake for delivery of cargo into other pertinent cells, such as VSMC.

scholarly journals Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

2021 ◽  
Vol 7 (9) ◽  
pp. eabf4398
Author(s):  
M. Kim ◽  
M. Jeong ◽  
S. Hur ◽  
Y. Cho ◽  
J. Park ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Targeted Delivery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Nanoparticles ◽  
Liver Sinusoidal Endothelial Cells ◽  
Main Challenge ◽  
Cell Type Specific ◽  
Selective Delivery

Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA therapeutics into the liver. However, a main challenge remains to develop LNP formulations for selective delivery of RNA into certain types of liver cells, such as hepatocytes and liver sinusoidal endothelial cells (LSECs). Here, we report the engineered LNPs for the targeted delivery of RNA into hepatocytes and LSECs. The effects of particle size and polyethylene glycol–lipid content in the LNPs were evaluated for the hepatocyte-specific delivery of mRNA by ApoE-mediated cellular uptake through low-density lipoprotein receptors. Targeted delivery of RNA to LSECs was further investigated using active ligands. Incorporation of mannose allowed the selective delivery of RNA to LSECs, while minimizing the unwanted cellular uptake by hepatocytes. These results demonstrate that engineered LNPs have great potential for the cell type–specific delivery of RNA into the liver and other tissues.

scholarly journals Single Chain Variable Fragment Fused to Maltose Binding Protein: A Modular Nanocarrier Platform for the Targeted Delivery of Antitumorals

2021 ◽  
Author(s):  
Francisco J. Reche-Perez ◽  
Simona Plesselova ◽  
Eduardo De los Reyes-Berbel ◽  
Mariano Ortega-Muñoz ◽  
F. Javier Lopez-Jaramillo ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Targeted Delivery ◽  
Specific Binding ◽  
Protein A ◽  
Antibody Fragments ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Binding Properties ◽  
Single Chain Variable Fragments ◽  
Selective Delivery

The use of the specific binding properties of monoclonal antibody fragments such as single-chain variable fragments (ScFv) for the selective delivery of antitumor therapeutics for cancer cells is attractive due...

Selective Delivery of an Acardiac, Acephalic Twin

1989 ◽  
Vol 320 (8) ◽  
pp. 512-513 ◽  
Author(s):  
George F. Robie ◽  
Gerald G. Payne ◽  
Mark A. Morgan
Keyword(s):  
Selective Delivery

scholarly journals Selective Delivery of Secretory Cargo in Golgi-Derived Carriers of Nonepithelial Cells

Traffic ◽  
2002 ◽  
Vol 3 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Amin Rustom ◽  
Mark Bajohrs ◽  
Christoph Kaether ◽  
Patrick Keller ◽  
Derek Toomre ◽  
...  
Keyword(s):  
Selective Delivery

A Novel Method for Selective Delivery of Drugs to the Pulmonary Arteries

Drug Delivery ◽  
2005 ◽  
Vol 12 (5) ◽  
pp. 261-265 ◽  
Author(s):  
Mark P. Yeager ◽  
Jeffrey A. Clark ◽  
Scott B. Yeager
Keyword(s):  
Pulmonary Arteries ◽  
Novel Method ◽  
Selective Delivery

The selective delivery of anticancer agents using target-sensitive liposomes

1996 ◽  
Vol 13 (4) ◽  
pp. 393-398 ◽  
Author(s):  
Taeboo Choe ◽  
Jaekyoung Ku ◽  
Seunho Jung ◽  
Jiwon Yang ◽  
Jongduk Kim
Keyword(s):  
Anticancer Agents ◽  
Selective Delivery
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