Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)

John Regan; Alison Capolino; Pier F. Cirillo; Thomas Gilmore; Anne G. Graham; Eugene Hickey; Rachel R. Kroe; Jeffrey Madwed; Monica Moriak; Richard Nelson; Christopher A. Pargellis; Alan Swinamer; Carol Torcellini; Michele Tsang; Neil Moss

doi:10.1021/jm030121k

Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)

Journal of Medicinal Chemistry ◽

10.1021/jm030121k ◽

2003 ◽

Vol 46 (22) ◽

pp. 4676-4686 ◽

Cited By ~ 68

Author(s):

John Regan ◽

Alison Capolino ◽

Pier F. Cirillo ◽

Thomas Gilmore ◽

Anne G. Graham ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitor ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity ◽

P38α Map Kinase

Download Full-text

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

Journal of Medicinal Chemistry ◽

10.1021/jm100540x ◽

2010 ◽

Vol 53 (18) ◽

pp. 6629-6639 ◽

Cited By ~ 38

Author(s):

Chunjian Liu ◽

James Lin ◽

Stephen T. Wrobleski ◽

Shuqun Lin ◽

John Hynes ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitor ◽

Inflammatory Diseases ◽

P38α Map Kinase

Download Full-text

Structure-activity relationships for insect growth regulators derived from substituted di-tert-butyl phenols

Pesticide Biochemistry and Physiology ◽

10.1016/0048-3575(79)90090-7 ◽

1979 ◽

Vol 12 (1) ◽

pp. 23-30 ◽

Cited By ~ 7

Author(s):

Barbara T. Walton ◽

James R. Sanborn ◽

Robert L. Metcalf

Keyword(s):

Growth Regulators ◽

Insect Growth Regulators ◽

Insect Growth ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity

Download Full-text

2-Aryl-5-tert-butyl-1,3-dithianes and their S-oxidation products: structure-activity relationships of potent insecticides acting at the GABA-gated chloride channel

Journal of Agricultural and Food Chemistry ◽

10.1021/jf00015a028 ◽

1992 ◽

Vol 40 (3) ◽

pp. 497-505 ◽

Cited By ~ 22

Author(s):

Vincent J. Wacher ◽

Robert F. Toia ◽

John E. Casida

Keyword(s):

Chloride Channel ◽

Oxidation Products ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity ◽

S Oxidation

Download Full-text

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)—A potent and efficacious p38α MAP kinase inhibitor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.02.031 ◽

2008 ◽

Vol 18 (6) ◽

pp. 1762-1767 ◽

Cited By ~ 18

Author(s):

John Hynes ◽

Hong Wu ◽

Sidney Pitt ◽

Ding Ren Shen ◽

Rosemary Zhang ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitor ◽

P38α Map Kinase

Download Full-text

Synthesis, Crystal Structures, Insecticidal Activities, and Structure−Activity Relationships of NovelN′-tert-Butyl-N′-substituted-benzoyl-N-[di(octa)hydro]benzofuran{(2,3-dihydro)benzo[1,3]([1,4])dioxine}carbohydrazide Derivatives

Journal of Agricultural and Food Chemistry ◽

10.1021/jf104196t ◽

2011 ◽

Vol 59 (2) ◽

pp. 635-644 ◽

Cited By ~ 16

Author(s):

Zhiqiang Huang ◽

Yuxiu Liu ◽

Yongqiang Li ◽

Lixia Xiong ◽

Zhipeng Cui ◽

...

Keyword(s):

Crystal Structures ◽

Tert Butyl ◽

Structure Activity Relationships ◽

Structure Activity ◽

Insecticidal Activities

Download Full-text

Synthesis and structure–activity relationships of thioflavone derivatives as specific inhibitors of the ERK-MAP kinase signaling pathway

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.02.002 ◽

2004 ◽

Vol 12 (9) ◽

pp. 2397-2407 ◽

Cited By ~ 33

Author(s):

Tadashi Kataoka ◽

Shin-ichi Watanabe ◽

Eiji Mori ◽

Ryoji Kadomoto ◽

Susumu Tanimura ◽

...

Keyword(s):

Map Kinase ◽

Signaling Pathway ◽

Kinase Signaling ◽

Structure Activity Relationships ◽

Structure Activity ◽

Map Kinase Signaling ◽

Kinase Signaling Pathway ◽

Map Kinase Signaling Pathway ◽

Specific Inhibitors

Download Full-text

ChemInform Abstract: The Discovery of N-Cyclopropyl-4-methyl-3- [6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703, a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases.

ChemInform ◽

10.1002/chin.201243208 ◽

2012 ◽

Vol 43 (43) ◽

pp. no-no

Author(s):

John G. Cumming ◽

et al. et al.

Keyword(s):

Map Kinase ◽

Kinase Inhibitor ◽

Inflammatory Diseases ◽

P38α Map Kinase

Download Full-text

The Protein Kinase Inhibitor Balanol: Structure – Activity Relationships and Structure-Based Computational Studies

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/187152008785133056 ◽

2008 ◽

Vol 8 (6) ◽

pp. 638-645 ◽

Cited By ~ 18

Author(s):

Vineet Pande ◽

Maria Ramos ◽

Federico Gago

Keyword(s):

Protein Kinase ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Computational Studies ◽

Structure Activity Relationships ◽

Structure Activity

Download Full-text

Quantitative structure activity relationship study of p38α MAP kinase inhibitors

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2013.05.009 ◽

2017 ◽

Vol 10 (1) ◽

pp. 33-40 ◽

Cited By ~ 10

Author(s):

Eslam Pourbasheer ◽

Sajjad Ahmadpour ◽

Rohollah Zare-Dorabei ◽

Mehdi Nekoei

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Study ◽

P38α Map Kinase

Download Full-text

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00839 ◽

2015 ◽

Vol 58 (19) ◽

pp. 7775-7784 ◽

Cited By ~ 2

Author(s):

Chunjian Liu ◽

James Lin ◽

John Hynes ◽

Hong Wu ◽

Stephen T. Wrobleski ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitor ◽

Phenyl Acetate ◽

P38α Map Kinase

Download Full-text