Synthesis, Nicotinic Acetylcholine Receptor Binding Affinities, and Molecular Modeling of Constrained Epibatidine Analogues

Zhi-Liang Wei; Pavel A. Petukhov; Yingxian Xiao; Werner Tückmantel; Clifford George; Kenneth J. Kellar; Alan P. Kozikowski

doi:10.1021/jm025613w

Synthesis, Nicotinic Acetylcholine Receptor Binding Affinities, and Molecular Modeling of Constrained Epibatidine Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm025613w ◽

2003 ◽

Vol 46 (6) ◽

pp. 921-924 ◽

Cited By ~ 20

Author(s):

Zhi-Liang Wei ◽

Pavel A. Petukhov ◽

Yingxian Xiao ◽

Werner Tückmantel ◽

Clifford George ◽

...

Keyword(s):

Molecular Modeling ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Binding Affinities ◽

Nicotinic Acetylcholine

Download Full-text

Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)00193-7 ◽

2001 ◽

Vol 11 (9) ◽

pp. 1245-1248 ◽

Cited By ~ 17

Author(s):

Rui Xu ◽

Linda P Dwoskin ◽

Vladimir P Grinevich ◽

Gabriela Deaciuc ◽

Peter A Crooks

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Binding Affinities ◽

Nicotinic Acetylcholine

Download Full-text

Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analoguesElectronic supplementary information (ESI) available: detailed experimental procedures with spectroscopic data, and crystal data for compounds 11 and 4a. See http://www.rsc.org/suppdata/ob/b3/b308906a/Dedicated to Dr John W. Daly of the NIH, who first discovered epibatidine.

Organic & Biomolecular Chemistry ◽

10.1039/b308906a ◽

2003 ◽

Vol 1 (22) ◽

pp. 3878 ◽

Cited By ~ 10

Author(s):

Zhi-Liang Wei ◽

Yingxian Xiao ◽

Clifford George ◽

Kenneth J. Kellar ◽

Alan P. Kozikowski

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Spectroscopic Data ◽

Supplementary Information ◽

Binding Affinities ◽

Crystal Data ◽

Nicotinic Acetylcholine

Download Full-text

Synthesis and nicotinic acetylcholine receptor binding affinities of 2- and 3-isoxazolyl-8-azabicyclo[3.2.1]octanes

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.01.025 ◽

2004 ◽

Vol 14 (7) ◽

pp. 1775-1778 ◽

Cited By ~ 8

Author(s):

Jie Cheng ◽

Sari Izenwasser ◽

Chunming Zhang ◽

Suhong Zhang ◽

Dean Wade ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Binding Affinities ◽

Nicotinic Acetylcholine

Download Full-text

Synthesis and Nicotinic Acetylcholine Receptor Binding Affinities of 2- and 3-Isoxazolyl-8-azabicyclo[3.2.1]octanes.

ChemInform ◽

10.1002/chin.200434215 ◽

2004 ◽

Vol 35 (34) ◽

Author(s):

Jie Cheng ◽

Sari Izenwasser ◽

Chunming Zhang ◽

Suhong Zhang ◽

Dean Wade ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Binding Affinities ◽

Nicotinic Acetylcholine

Download Full-text

P3-428: Stability of nicotinic acetylcholine receptor binding in the frontal and temporal cortex of subjects with mild cognitive impairment

Alzheimer s & Dementia ◽

10.1016/j.jalz.2006.05.1699 ◽

2006 ◽

Vol 2 ◽

pp. S502-S502

Author(s):

Steven Trent DeKosky ◽

Lynn Wecker ◽

Tina Pastoor ◽

Joanne Wuu ◽

Elliott J. Mufson ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Temporal Cortex ◽

Nicotinic Acetylcholine

Download Full-text

Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression

Brain Research ◽

10.1016/j.brainres.2006.06.084 ◽

2006 ◽

Vol 1113 (1) ◽

pp. 94-109 ◽

Cited By ~ 37

Author(s):

L.Z. Huang ◽

U.H. Winzer-Serhan

Keyword(s):

Mrna Expression ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Nicotinic Acetylcholine ◽

Subunit Mrna

Download Full-text

Nudicauline and Elatine as Potent Norditerpenoid Ligands at Rat Neuronal α-Bungarotoxin Binding Sites: Importance of the 2-(Methylsuccinimido)benzoyl Moiety for Neuronal Nicotinic Acetylcholine Receptor Binding

Journal of Medicinal Chemistry ◽

10.1021/jm9604991 ◽

1996 ◽

Vol 39 (24) ◽

pp. 4860-4866 ◽

Cited By ~ 53

Author(s):

David J. Hardick ◽

Ian S. Blagbrough ◽

Gary Cooper ◽

Barry V. L. Potter ◽

Trevor Critchley ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Binding Sites ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

Download Full-text

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.07.021 ◽

2015 ◽

Vol 23 (17) ◽

pp. 5693-5701 ◽

Cited By ~ 1

Author(s):

Pauline W. Ondachi ◽

Zhuo Ye ◽

Ana H. Castro ◽

Charles W. Luetje ◽

M. Imad Damaj ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Nicotinic Acetylcholine

Download Full-text

Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism

Journal of Agricultural and Food Chemistry ◽

10.1021/jf4030695 ◽

2013 ◽

Vol 61 (33) ◽

pp. 7883-7888 ◽

Cited By ~ 38

Author(s):

Xusheng Shao ◽

Tami L. Swenson ◽

John E. Casida

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Receptor Binding Site ◽

Nicotinic Acetylcholine

Download Full-text

Lower cortical Alpha4Beta2 nicotinic acetylcholine receptor binding and its relationship to cognitive dysfunction in early stage multiple sclerosis: A 2-[18F]F-A-85380 PET study

NeuroImage ◽

10.1016/j.neuroimage.2010.04.090 ◽

2010 ◽

Vol 52 ◽

pp. S111

Author(s):

Philipp M. Meyer ◽

Katharina Kurtz ◽

Eva Thomae ◽

Georg Becker ◽

Andreas Schildan ◽

...

Keyword(s):

Multiple Sclerosis ◽

Acetylcholine Receptor ◽

Cognitive Dysfunction ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Early Stage ◽

Nicotinic Acetylcholine

Download Full-text