3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

2003 ◽  
Vol 46 (2) ◽  
pp. 204-206 ◽  
Author(s):  
Nicholas D. P. Cosford ◽  
Lida Tehrani ◽  
Jeffrey Roppe ◽  
Edwin Schweiger ◽  
Nicholas D. Smith ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Anxiolytic Activity ◽  
Metabotropic Glutamate

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: A Highly Potent, Orally Active, Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonist.

ChemInform ◽  
2005 ◽  
Vol 36 (14) ◽  
Author(s):  
Dehua Huang ◽  
Steve F. Poon ◽  
Deborah F. Chapman ◽  
Janice Chung ◽  
Merryl Cramer ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Metabotropic Glutamate ◽  
Mglu5 Receptor ◽  
Orally Active

Long-term depression of naive synapses in adult hippocampus induced by asynchronous synaptic activity

1995 ◽  
Vol 73 (6) ◽  
pp. 2596-2601 ◽  
Author(s):  
S. Otani ◽  
J. A. Connor
Keyword(s):  
Receptor Antagonist ◽  
Metabotropic Glutamate Receptor ◽  
Hippocampal Slices ◽  
Synaptic Activity ◽  
Synthesis Inhibitor ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Adult Rat ◽  
Adult Hippocampus

1. Two independent Schaffer collateral pathways converging to the same pyramidal cell were alternately stimulated by 2-Hz trains (900 pulses) offset by a 150-ms interval in adult rat hippocampal slices. The second input underwent an immediate and persistent long-term depression (LTD). Depression in the first input was smaller than the second input. A narrower interpulse interval (20 ms) failed to induce LTD in either input. 2. Neither the N-methyl-D-aspartate receptor antagonist DL-2-amino-5-phosphonovaleric acid nor the metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxylphenyl-glycine blocked this associative LTD. However, coapplication of these two antagonists blocked LTD. 3. Associative LTD was blocked by prior injection of the Ca2+ chelator bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid into the postsynaptic cell and by bath-applied L-NG-nitroarginine, a nitric oxide synthesis inhibitor. 4. We propose that temporally confined, asynchronous synaptic activity weakens the efficacy of naive synapses in slices from the adult hippocampus.

The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death

2002 ◽  
Vol 42 (6) ◽  
pp. 741-751 ◽  
Author(s):  
Flavio Moroni ◽  
Sabina Attucci ◽  
Andrea Cozzi ◽  
Elena Meli ◽  
Roberta Picca ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Neuronal Death ◽  
The Novel ◽  
Metabotropic Glutamate ◽  
Mglu1 Receptor
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