6-Sulfonylchromenes as Highly Potent KATP-Channel Openers

2002 ◽  
Vol 45 (5) ◽  
pp. 1086-1097 ◽  
Author(s):  
Ekkehart Salamon ◽  
Raimund Mannhold ◽  
Horst Weber ◽  
Horst Lemoine ◽  
Walter Frank
Keyword(s):  
Katp Channel ◽  
Katp Channel Openers

Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

2010 ◽  
Vol 7 (6) ◽  
pp. 415-420 ◽  
Author(s):  
Jinpei Zhou ◽  
Hai Qian ◽  
Huibin Zhang ◽  
Hui Gao ◽  
Wenlong Huang ◽  
...  
Keyword(s):  
Katp Channel ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Katp Channel Openers

KATP channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production

2010 ◽  
Vol 88 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Juan Xie ◽  
Lei Duan ◽  
Xia Qian ◽  
Xu Huang ◽  
Jianhua Ding ◽  
...  
Keyword(s):  
Katp Channel ◽  
Ros Production ◽  
Katp Channel Openers

Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)

2002 ◽  
Vol 12 (11) ◽  
pp. 1481-1484 ◽  
Author(s):  
Irene Drizin ◽  
Mark W. Holladay ◽  
Lin Yi ◽  
Henry Q. Zhang ◽  
Sujatha Gopalakrishnan ◽  
...  
Keyword(s):  
Katp Channel ◽  
Structure Activity ◽  
Katp Channel Openers

scholarly journals Diazoxide and Exercise Enhance Muscle Contraction during Obesity by Decreasing ROS Levels, Lipid Peroxidation, and Improving Glutathione Redox Status

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1232
Author(s):  
Mariana Gómez-Barroso ◽  
Koré M. Moreno-Calderón ◽  
Elizabeth Sánchez-Duarte ◽  
Christian Cortés-Rojo ◽  
Alfredo Saavedra-Molina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Lipid Peroxidation ◽  
Muscle Contraction ◽  
Katp Channel ◽  
Metabolic Stress ◽  
Muscular Contraction ◽  
Redox Status ◽  
Glutathione Redox ◽  
Katp Channel Openers

Obesity causes insulin resistance and hyperinsulinemia which causes skeletal muscle dysfunction resulting in a decrease in contraction force and a reduced capacity to avoid fatigue, which overall, causes an increase in oxidative stress. KATP channel openers such as diazoxide and the implementation of exercise protocols have been reported to be actively involved in protecting skeletal muscle against metabolic stress; however, the effects of diazoxide and exercise on muscle contraction and oxidative stress during obesity have not been explored. This study aimed to determine the effect of diazoxide in the contraction of skeletal muscle of obese male Wistar rats (35 mg/kg), and with an exercise protocol (five weeks) and the combination from both. Results showed that the treatment with diazoxide and exercise improved muscular contraction, showing an increase in maximum tension and total tension due to decreased ROS and lipid peroxidation levels and improved glutathione redox state. Therefore, these results suggest that diazoxide and exercise improve muscle function during obesity, possibly through its effects as KATP channel openers.

Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation

1996 ◽  
Vol 271 (6) ◽  
pp. L924-L931 ◽  
Author(s):  
B. J. DeWitt ◽  
D. Y. Cheng ◽  
T. J. McMahon ◽  
J. R. Marrone ◽  
H. C. Champion ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Katp Channel ◽  
Blocking Agent ◽  
Vasodilator Agents ◽  
Vascular Bed ◽  
Pulmonary Vasodilator ◽  
Channel Blocking ◽  
Vascular Beds ◽  
Resting Tone ◽  
Katp Channel Openers

The effects of the vascular selective nonsulfonylurea guanidine ATP-sensitive K+ (KATP+) channel-blocking agent U-37883A on vasodilator and vasoconstrictor responses were investigated in the pulmonary and hindlimb vascular beds of the cat. Under elevated tone conditions, both U-37883A and the sulfonylurea KATP+ antagonist, glibenclamide, attenuated pulmonary vasodilator responses to the KATP+ channel openers without altering responses to vasodilator agents that are reported to act by KATP(+)-independent mechanisms. However, under low resting-tone conditions, U-37883A enhanced pulmonary vasoconstrictor responses to the thromboxane mimic U-46619 and to prostaglandin (PG) F2 alpha and PGD2, whereas glibenclamide antagonized responses to U-46619 and the vasoconstrictor PG. In the hindlimb vascular bed, U-37883A and glibenclamide had no effects on responses to U-46619 in doses that inhibited vasodilator responses to the KATP+ channel opener levcromakalim. U-37883A and glibenclamide had no significant effect on baseline tone in the pulmonary or hindlimb vascular beds, and neither U-37883A nor glibenclamide altered pulmonary vasodilator responses to PGE1. The results of the present investigation show that U-37883A and glibenclamide, agents that are used in the study of vascular smooth muscle KATP+ channel mechanisms and attenuate vasodilator responses to the KATP+ channel openers, have pronounced effects on thromboxane/PG receptor-mediated vasoconstrictor responses in the pulmonary vascular bed of the cat.

Mitochondrial production of free radicals blunted by KATP channel openers

2001 ◽  
Vol 33 (6) ◽  
pp. A88
Author(s):  
Cevher Ozcan ◽  
Petras P. Dzeja ◽  
Martin Blenengraeber ◽  
Andre Terzic
Keyword(s):  
Free Radicals ◽  
Katp Channel ◽  
Katp Channel Openers

scholarly journals Binding and effect of KATP channel openers in the absence of Mg2+

2003 ◽  
Vol 139 (2) ◽  
pp. 368-380 ◽  
Author(s):  
Ulrich Russ ◽  
Ulf Lange ◽  
Cornelia Löffler-Walz ◽  
Annette Hambrock ◽  
Ulrich Quast
Keyword(s):  
Katp Channel ◽  
Katp Channel Openers
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