Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà

doi:10.1021/jm010995b

Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm010995b ◽

2002 ◽

Vol 45 (5) ◽

pp. 1035-1044 ◽

Cited By ~ 61

Author(s):

Flavia Varano ◽

Daniela Catarzi ◽

Vittoria Colotta ◽

Guido Filacchioni ◽

Alessandro Galli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Biological Evaluation ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists ◽

Synthesis And Biological Evaluation

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Effects ofin situadministration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury

Neurological Research ◽

10.1179/016164107x251745 ◽

2008 ◽

Vol 30 (4) ◽

pp. 420-429 ◽

Cited By ~ 9

Author(s):

Takeshi Suma ◽

Morimichi Koshinaga ◽

Masamichi Fukushima ◽

Tsuneo Kano ◽

Yoichi Katayama

Keyword(s):

Traumatic Brain Injury ◽

Amino Acid ◽

Brain Injury ◽

Excitatory Amino Acid ◽

Rat Hippocampus ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Excitatory Amino Acid Antagonists and Pentylenetetrazol-induced Seizures During Ontogenesis. IV. Effects of CGP 39551

Pharmacology Biochemistry and Behavior ◽

10.1016/s0091-3057(96)00245-6 ◽

1997 ◽

Vol 56 (3) ◽

pp. 493-498 ◽

Cited By ~ 10

Author(s):

Libor Velíšek ◽

Dana Vachová ◽

Pavel Mareš

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Cgp 39551 ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro

Journal of Neuroscience Research ◽

10.1002/(sici)1097-4547(19970615)48:6<499::aid-jnr2>3.0.co;2-5 ◽

1997 ◽

Vol 48 (6) ◽

pp. 499-506 ◽

Cited By ~ 9

Author(s):

F. Dorandeu ◽

J. Wetherell ◽

I. Pernot-Marino ◽

J.E.H. Tattersall ◽

P. Fosbraey ◽

...

Keyword(s):

Amino Acid ◽

Neurotransmitter Release ◽

Excitatory Amino Acid ◽

Rat Hippocampus ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Behavioural and eeg effects of some excitatory amino acid antagonists

Pharmacological Research Communications ◽

10.1016/s0031-6989(88)80017-1 ◽

1988 ◽

Vol 20 (5) ◽

pp. 409-410 ◽

Cited By ~ 1

Author(s):

M. Benedetti ◽

S. Sagratella ◽

A. Scotti de Carolis

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00383 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5216-5221 ◽

Cited By ~ 5

Author(s):

Alessia Chelini ◽

Simone Brogi ◽

Marco Paolino ◽

Angela Di Capua ◽

Andrea Cappelli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Biological Evaluation ◽

Excitatory Amino Acid Transporter ◽

Acid Transporter ◽

Pyridazine Derivatives ◽

Synthesis And Biological Evaluation

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Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

Trends in Pharmacological Sciences ◽

10.1016/0165-6147(93)90005-5 ◽

1993 ◽

Vol 14 (9) ◽

pp. 325-331 ◽

Cited By ~ 217

Author(s):

Michael A. Rogawski

Keyword(s):

Amino Acid ◽

Therapeutic Potential ◽

Excitatory Amino Acid ◽

Channel Blockers ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

Brain Research ◽

10.1016/0006-8993(90)91195-m ◽

1990 ◽

Vol 506 (1) ◽

pp. 31-39 ◽

Cited By ~ 260

Author(s):

Anthony H. Dickenson ◽

Ann F. Sullivan

Keyword(s):

Amino Acid ◽

Dorsal Horn ◽

Excitatory Amino Acid ◽

Differential Effects ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. I. The effects of excitatory amino acid antagonists

Brain Research ◽

10.1016/0006-8993(85)91229-6 ◽

1985 ◽

Vol 360 (1-2) ◽

pp. 139-148 ◽

Cited By ~ 55

Author(s):

Lennart Brodin ◽

Sten Grillner

Keyword(s):

Spinal Cord ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Neurotransmitters ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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Hypoxic Neurodegeneration in Culture: Calcium Influx, Electron Microscopy, and Neuroprotection with Excitatory Amino Acid Antagonists

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1992.tb24563.x ◽

1992 ◽

Vol 648 (1 Neurotoxins a) ◽

pp. 303-305 ◽

Cited By ~ 7

Author(s):

FRANK W. MARCOUX ◽

MARK L. WEBER ◽

ALBERT W. PROBERT ◽

MARK A. DOMINICK

Keyword(s):

Electron Microscopy ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Calcium Influx ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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The pharmacology of excitatory amino acid antagonists in an animal model of stroke

European Neuropsychopharmacology ◽

10.1016/0924-977x(94)90091-4 ◽

1994 ◽

Vol 4 (3) ◽

pp. 279-281

Author(s):

R. Gill

Keyword(s):

Animal Model ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

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